Acid-Stable Serine Proteinase Inhibitors in the Urine of Alzheimer Disease Subjects [PDF]
, 1996 A comparative study of the levels of acid-stable proteinase inhibitors (kallikrein and trypsin inhibitors) in the urine of healthy and Alzheimer subjects, of both sexes, has been performed.
Angeletti, M. +9 more
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Markov modeling of peptide folding in the presence of protein crowders [PDF]
J. Chem. Phys. 148, 055101 (2018), 2018 We use Markov state models (MSMs) to analyze the dynamics of a $\beta$-hairpin-forming peptide in Monte Carlo (MC) simulations with interacting protein crowders, for two different types of crowder proteins [bovine pancreatic trypsin inhibitor (BPTI) and GB1].
arxiv +1 more source
Amino acid sequence elucidation of human acrosin-trypsin inhibitor (HUSI-II) reveals that Kazal-type proteinase inhibitors are structurally related to β-subunits of glycoprotein hormones [PDF]
, 1990 The amino acid sequence of the acrosin-trypsin inhibitor HUSI-II from human seminal plasma is presented which unequivocally identifies HUSI-II as being of Kazal-type.
Eulitz, Manfred +2 more
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Recent advances in computational methods for studying ligand binding kinetics [PDF]
arXiv, 2022 Binding kinetic parameters can be correlated with drug efficacy, which led to the development of various computational methods for predicting binding kinetic rates and gaining insight into protein-drug binding paths and mechanisms in recent years. In this review, we introduce and compare computational methods recently developed and applied to two ...
arxiv
In silico identification of potential natural product inhibitors of human proteases key to SARS-CoV-2 infection [PDF]
Molecules 2020, 25(17), 3822, 2020 Presently, there are no approved drugs or vaccines to treat COVID-19 which has spread to over 200 countries and is responsible for over 3,65,000 deaths worldwide. Recent studies have shown that two human proteases, TMPRSS2 and cathepsin L, play a key role in host cell entry of SARS-CoV-2.
arxiv +1 more source
Quantifying the influence of conformational uncertainty in biomolecular solvation [PDF]
Multiscale.Model.Simul 13 (2015) 1327-1353, 2014 Biomolecules exhibit conformational fluctuations near equilibrium states, inducing uncertainty in various biological properties in a dynamic way. We have developed a general method to quantify the uncertainty of target properties induced by conformational fluctuations. Using a generalized polynomial chaos (gPC) expansion, we construct a surrogate model
arxiv +1 more source
Primary structure of potato Kunitz-type serine proteinase inhibitor [PDF]
, 2000 The serine proteinase inhibitor (PSPI-51) isolated from potato tubers (Solanum tuberosum L,) comprises two protein species with pi 5.2 and 6.3, denoted as PSPI-21-5.2 and PSPI-21-6.3, respectively.
Mentele, Reinhard +3 more
core +1 more source
Weak self-interactions of globular proteins studied by small-angle X-ray scattering and structure-based modeling [PDF]
J. Phys. Chem. B 118, 10111-10119 (2014), 2014 We investigate protein-protein interactions in solution by small-angle X-ray scattering (SAXS) and theoretical modeling. The structure factor for solutions of bovine pancreatic trypsin inhibitor (BPTI), myoglobin (Mb), and intestinal fatty acid-binding protein (IFABP) is determined from SAXS measurements at multiple concentrations, from Monte Carlo ...
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Structure and kinetics of chemically cross-linked protein gels from small-angle X-ray scattering [PDF]
Phys. Chem. Chem. Phys. 16, 4002-4011 (2014), 2013 Glutaraldehyde (GA) reacts with amino groups in proteins, forming intermolecular cross-links that, at sufficiently high protein concentration, can transform a protein solution into a gel. Although GA has been used as a cross-linking reagent for decades, neither the cross-linking chemistry nor the microstructure of the resulting protein gel have been ...
arxiv +1 more source
Medium dependence of asphaltene agglomeration inhibitor efficiency [PDF]
Energy & Fuels vol.22, 2008, pp 1917 - 1922;, 2007 Applying chemical additives (molecule inhibitors or dispersants) is one of the common ways to control asphaltene agglomeration and precipitation. However, it is not clear why at some conditions the synthetic flocculation inhibitors as well as resins not only do not inhibit the asphaltene agglomeration,, they may also promote it, and why the increasing ...
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