Results 101 to 110 of about 5,000 (229)

Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?

British Journal of Pharmacology, EarlyView.
Psychedelic drugs that activate 5‐HT2A receptors have been long used for cultural, medicinal and recreational purposes. Interest in psychedelics for treating psychiatric disorders has resurged recently and is well documented; less well recognised are their anti‐inflammatory properties. Growing evidence now demonstrates that psychedelics modulate immune
Omar Qureshi, Jamie Cowley, Ashley Pegg, Alison J. Cooper, John Gordon, Catherine A. Brady, Antonio Belli, Sam Butterworth, Rachel Upthegrove, Nick Andrews, Nicholas M. Barnes   +10 more
wiley   +1 more source

Novel psychoactive substances (designer drugs): overview and pharmacology of modulators of monoamine signalling

Swiss Medical Weekly, 2015
Novel psychoactive substances are newly used designer drugs (“internet drugs”, “research chemicals”, “legal highs”) potentially posing similar health risks to classic illicit substances.
Matthias Liechti
doaj   +1 more source

An adolescent with an altered state of mind [PDF]

, 2015
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Moressa, Valentina, Naviglio, Samuele, Papanti, Duccio, Ventura, Alessandro   +3 more
core   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

\u3cem\u3eIn Vitro\u3c/em\u3e Determination of Potency of Small Molecule Inhibitors of Arp2/3 Complex [PDF]

, 2019
Actin is a key protein building block of actin microfilaments, which are constructed and deconstructed in response to cellular signaling pathways to regulate cellular processes such as motility, division, and endocytosis.
Andersen, Katherine, Baggett, Andrew W., Cavas, Levent, Collins, Jordan, Cournia, Zoe, DeRocher, Shelby, Nolen, Brad J., Pierson, Christina, Wade, Natalie   +8 more
core   +1 more source

Analytical characterization of bioactive N-benzyl-substituted phenethylamines and 5-methoxytryptamines [PDF]

RationaleSubstances based on the N-(2-methoxybenzyl)phenethylamine template ('NBOMe' derivatives) play an important role in medicinal research but some of these derivatives have also appeared as 'research chemicals' for recreational use which has ...
Brandt, SD, Dempster, NM, Elliott, SP, Kavanagh, PV, Maurer, HH, Meyer, MR, Nichols, DE   +6 more
core   +1 more source

Direct C7 Functionalization of Tryptophan. Synthesis of Methyl ( S )-2-(( tert -Butoxycarbonyl)amino)-3-(7-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)-1 H -indol-3-yl)propanoate [PDF]

, 2015
National Institute of General Medical Sciences (U.S.) (GM089732)National Institute of General Medical Sciences (U.S.) (GM074825)National Science Foundation (U.S.) (CHE ...
Amaike, Kazuma, Loach, Richard Peter, Movassaghi, Mohammad   +2 more
core   +1 more source

Variation in Microbiome Composition and Faecal Metabolites Are Associated With Differential Susceptibility to DSS‐Induced Colitis

Immunology, EarlyView.
C57BL/6 mice from Charles River Laboratories (CR) have enhanced mucosal immune action relative to C57BL/6 mice from Jackson Laboratories (JAX). CR mice are more susceptible to severe DSS‐induced colitis than JAX mice. Co‐housing transfers colitis susceptibility from CR mice to JAX mice.
Jessica M. Till, Orion D. Brock, Elyza A. Do, Morgan J. Engelhart, Robert W. P. Glowacki, Shaomin Hu, Ansel Hsiao, Ina Nemet, Philip P. Ahern   +8 more
wiley   +1 more source

Designer drugs: aspectos analíticos e biológicos

Química Nova, 2012
In the recent years, analytical toxicologists have been facing difficulties in detecting designer drugs due to the chemical modifications on the existing structures and the speed in which they are released into the market, requiring the development and ...
Rachel Bulcão, Solange Cristina Garcia, Renata Pereira Limberger, Marília Baierle, Marcelo Dutra Arbo, Alice Aparecida da Matta Chasin, Flávia Valladão Thiesen, Rejane Tavares   +7 more
doaj   +1 more source

Tryptophan‐Derived Microbial Metabolite Indole‐3‐Acetic Acid Ameliorates Periodontitis Through AhR/CYP1A1‐Mediated Macrophage Polarisation

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To investigate the association between tryptophan‐derived microbial metabolites and periodontitis, and to assess whether the differential tryptophan metabolite indole‐3‐acetic acid (IAA) could ameliorate periodontitis and elucidate its potential mechanism.
Shuyu Cheng, Shiyuan Song, Wen Zhang, Dan Qiao, Min Wang, Zhifeng Wang, Jiajie Pu, Wenrong Yang, Fuhua Yan, Yangheng Zhang   +9 more
wiley   +1 more source