Results 121 to 130 of about 5,094 (245)

Targeting of Gut Microbiota by Bioactive Peptides for the Improvement of Metabolic Diseases: A Review

Food Frontiers, Volume 7, Issue 3, May 2026.
Bioactive peptides (BPs) derived from dietary proteins modulate the gut microbiotametabolism axis by reshaping microbial composition and regulating key metabolites, including short‐chain fatty acids. BPs also enhance intestinal barrier integrity and immune homeostasis, thereby reducing inflammation.
Jiao Li, Yongchao Chen, Zhihua Li, Gang Liu, Hongmei Jiang, Jun Fang, Sujuan Ding   +6 more
wiley   +1 more source

Genetic Basis of the Negative Response to the Use of Triptans for the Treatment of Migraine—A Systematic Review and Meta‐Analysis

Brain and Behavior
Introduction Migraine is a widespread and disabling neurological disorder, and triptans are a primary treatment for acute episodes. However, around 40% of patients are non‐responsive.
Victoria Gomes Andreata, Ruan Pablo Duarte Freitas, Jéssica da Silva Nascimento, Patrícia Sodré Araújo, Felipe Eustáquio dos Santos Guedes, João Vítor Benjamim Pires, Narel Moita Carneiro Nogueira Falcão, Natasha da Silva Leitão, Alcylene Carla de Jesus dos Santos, Ana Patrícia Pascoal Queiroz, Astria Ferrão Dias Gonzales, Maica Matos Leão, Emília Katiane Embiruçu de Araújo Leão, Juliana Côrtes Freitas, Acássia Benjamim Leal Pires   +14 more
doaj   +1 more source

A Distinct Tryptophan Metabolic Phenotype Marks Severe Fatigue in Quiescent Crohn's Disease

JCC Plus, Volume 1, Issue 3, May 2026.
ABSTRACT Background Fatigue is a common and debilitating symptom in inflammatory bowel disease (IBD), but its underlying mechanisms remain unclear. Altered tryptophan metabolism may contribute to fatigue. Tryptophan is metabolized through the kynurenine, serotonin, and indole pathway, involving host and microbial processes. We aimed to explore the link
Paula I. Metselaar, Mees J. van der Hoff, Naomi V. Wieser, Olaf Welting, Antoine Lefèvre, Camille Dupuy, Patrick Emond, Joep P. M. Derikx, Wouter J. de Jonge, Geert R. A. M. D'Haens, Anje A. te Velde, Mark Löwenberg, Mohammed Ghiboub   +12 more
wiley   +1 more source

Tryptamine receptors [PDF]

The Journal of Physiology, 1953
openaire   +2 more sources

Smart shops: a survey of products, claimed effects and medical-toxicological relevance [PDF]

, 1999
During the last few years the use of herbal drugs of abuse, so-called 'smart products' and eco-drugs has increased. Many of these products have psychoactive effects.
Beltman W, Hengel-Koot IS van den, Meulenbelt J, Riel AJHP van, Vries I de, Vriesman MF, Wijnands-Kleukers APG   +6 more
core  

A Novel Multimodal LC–MS/MS Panel for the Comprehensive Diagnosis of Neurometabolic Disorders in CSF

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Metabolic testing of cerebrospinal fluid (CSF) is essential for early diagnosis of neurometabolic disorders. However, the large number of differential diagnoses, the phenotypic variance within a clinical picture, and the disease rarity complicate targeted metabolic diagnostics.
Stine Christ, Julia Rossmann, Sylvia Richter, Sven Garbade, Glynis Klinke, Nenad Blau, Georg Friedrich Hoffmann, Jürgen Günther Okun, Thomas Opladen   +8 more
wiley   +1 more source

Monitoring Biogenic Amines: Comparative Assessment of Detection Methods for Key Market Marine and Freshwater Species

Journal of Food Science, Volume 91, Issue 5, May 2026.
ABSTRACT Biogenic amines, primarily histamine, cadaverine, and putrescine, are important indicators of microbial spoilage and potential health risks. This review summarizes established and novel analytical methods for quantitatively determining biogenic amines in fish and fish products, along with their limits of detection in these complex matrices ...
Lasse Petersen
wiley   +1 more source

Tandem MADS‐Box Genes FUL2 and MADS1 Form a Regulatory Module to Repress Serotonin Biosynthesis via Direct ASMT5 Activation in Tomato Fruit

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2891-2902, May 2026.
ABSTRACT The regulation of serotonin metabolism during fruit development and ripening remains poorly understood, despite its potential roles in plant defence and human nutrition. Here, we demonstrated that the MADS‐box transcription factor FUL2 acts as a key repressor of serotonin accumulation in tomato by forming a functional module with MADS1. CRISPR‐
Yaping Xu, Huimin Jia, Dengguo Tang, Lijun Zhang, Xinqin Liu, Junjie Rong, Yunai Lv, Zhaobo Lang, Qingfeng Niu   +8 more
wiley   +1 more source

Three Closely Related Spodoptera Species Similarly Affect Gene Expression and Phytohormone Levels but Differentially Induce Volatile Emissions in Maize

Plant, Cell &Environment, Volume 49, Issue 5, Page 2394-2412, May 2026.
ABSTRACT Plants can perceive specific elicitors in the oral secretions (OS) of herbivorous insects and respond by increasing their defences. Whether plants can discriminate among similar herbivorous insect species and differentially modulate their defence responses against them is largely unknown.
Wenfeng Ye, Sara Leite Dias, Marine Mamin, Carla C. M. Arce, Ted C. J. Turlings   +4 more
wiley   +1 more source

Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro04-6790 [PDF]

, 2018
Rationale: Accumulating evidence suggests a potential role for the 5-HT6 receptor in cognitive function and the potential use of 5-HT6 receptor antagonists in the treatment of learning and memory disorders. Objectives: The aim of the current study was to
Fone, Kevin, Marsden, Charles, Sleight, Andrew, Woolley, Marie   +3 more
core