iMetaMed, EarlyView.The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang +3 more
wiley +1 more source
N-Benzyl-5-methoxytryptamines as Potent Serotonin 5-HT2 Receptor Family Agonists and Comparison with a Series of Phenethylarnine Analogues [PDF]
A series of N-benzylated-5-methoxytryptamine analogues was prepared and investigated, with special emphasis on substituents in the meta position of the benzyl group.
Brandt, SD +6 more
core +1 more source
The effect of particular active substances of hallucinogenic mushrooms [PDF]
, 2014 This mini review presents the influence of psilocybin, psilocin, ibotenic acid and muscimol on the nervous system. Also the effects of the above mentioned substances on emotion and mental health of people are discussed.Grzyby halucynogenne są spożywane ...
Wieczorek, Marek
core +1 more source
Monoaminergic Networks of Cognitive and Behavioral Symptoms in Early Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background Parkinson's disease (PD) is associated with several behavioral and cognitive symptoms, the neurobiological background of which is not yet fully understood. Objectives The aim was to investigate the association between monoamine function and four specific nonmotor symptoms in early PD using the Parkinson's Progression Markers ...
Kalle J. Niemi +3 more
wiley +1 more source
In vitro monoamine oxidase inhibition potential of alpha- methyltryptamine analog new psychoactive substances for assessing possible toxic risks [PDF]
Tryptamines have emerged as new psychoactive substances (NPS), which are distributed and consumed recreationally without preclinical studies or safety tests.
Brandt, SD +4 more
core +1 more source
The ketogenic diet alters microbiome‐metabolome profiles to improve West syndrome therapy
Pediatric Investigation, EarlyView.The ketogenic diet alleviates West syndrome by reshaping gut microbiota (increasing Bacteroides, Parabacteroides, and reducing Escherichia and Bifidobacterium), and modulating metabolites—including anticonvulsant lipids (e.g., capric acid), suppressed harmful lipids (e.g., 2‐methylbutyroylcarnitine), and amino acids and analogs (e.g., 3‐sulfinoalanine)—
Gan Xie +5 more
wiley +1 more source
Electrophilic carbonyl activation: competing condensative cyclizations of tryptamine derivatives [PDF]
, 2014 A series of tryptamine derived bisindole substrates were subjected to electrophilic activation of the func-tional grouping at their [alpha]-nitrogen in the form of iminium ions to enable cyclization onto the sterically hindered indole substructure.
Liu, Fan, Movassaghi, Mohammad
core +1 more source
PLANTS, PEOPLE, PLANET, EarlyView.Fungal systematics can feel overwhelming given the vast species diversity within this kingdom, with numerous subgroups at every taxonomic rank. This often creates a disconnect between the undertsnidng of fungal taxonomic diversity and their societal relevance.
Anna Vaiana +4 more
wiley +1 more source
Is there mush-room to improve the environmental sustainability of psilocybin production?
Journal of CO2 UtilizationMental health disorders and associated economic impact continue to rise domestically and globally. In 2023, to expand treatment options for individuals suffering Treatment Resistant Depression (TRD), the Therapeutic Goods Administration (TGA) of ...
Luke Lanham +2 more
doaj +1 more source
The fumarate salts of the N-isopropyl-N-methyl derivatives of DMT and psilocin
Acta Crystallographica Section E: Crystallographic Communications, 2019 The solid-state structures of the salts of two substituted tryptamines, namely N-isopropyl-N-methyltryptaminium (MiPT) fumarate {systematic name: [2-(1H-indol-3-yl)ethyl](methyl)propan-2-ylazanium 3-carboxyprop-2-enoate}, C14H21N2+·C4H3O4−, and 4-hydroxy-
Andrew R. Chadeayne +3 more
doaj +1 more source