Results 71 to 80 of about 3,690 (207)

Direct Conversion of Aryl Iodides Into Benzylamines by Aminomethylation: Reaction Scope, Mechanistic Studies, and Applications

European Journal of Organic Chemistry, Volume 29, Issue 37, 1 October 2026.
This study presents an efficient aminomethylation of aryl iodides with formamides for the synthesis of benzylamines using a reusable palladium catalyst at a loading of 65 mol ppm. The substrate scope is systematically evaluated, and mechanistic investigations provide insight into the reaction pathway and the origin of the observed catalytic efficiency.
Abhijit Sen, Atsuya Muranaka, Yu Hatakenaka, Aya Ohno, Yoichi M. A. Yamada   +4 more
wiley   +1 more source

Foxy, a Designer Tryptamine Hallucinogen* [PDF]

Journal of Analytical Toxicology, 2003
Foxy is slang for 5-methoxy-N,N-diisopropyltryptamine. It has hallucinogenic properties, similar to other tryptamine compounds, and is mildly euphoric. This case report describes a 21-year-old Caucasian man who ingested a pill called Foxy containing an unknown amount of drug.
Robert, Meatherall, Pankaj, Sharma
openaire   +2 more sources

The fumarate salts of the N-isopropyl-N-methyl derivatives of DMT and psilocin

Acta Crystallographica Section E: Crystallographic Communications, 2019
The solid-state structures of the salts of two substituted tryptamines, namely N-isopropyl-N-methyltryptaminium (MiPT) fumarate {systematic name: [2-(1H-indol-3-yl)ethyl](methyl)propan-2-ylazanium 3-carboxyprop-2-enoate}, C14H21N2+·C4H3O4−, and 4-hydroxy-
Andrew R. Chadeayne, Duyen N. K. Pham, James A. Golen, David R. Manke   +3 more
doaj   +1 more source

Microbiome‐Derived Tryptophan Metabolites Regulate AhR Signaling to Restore Epithelial Barrier Integrity in Inflammatory Bowel Disease

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
The graphical abstract illustrates how microbiome‐derived indoles activate the aryl hydrocarbon receptor to restore the intestinal barrier. The picture contrasts the “leaky gut” state with the restored homeostasis achieved through AMPK, Nrf2, and IL‐22 signaling.
Mohammad Ali Mahdiabadi, Asma Moghaddam, Nafiseh Erfanian   +2 more
wiley   +1 more source

Comprehensive in vitro profiling of traditional and emerging stimulants at monoamine transporters and the 5‐HT2A receptor

British Journal of Pharmacology, Volume 183, Issue 19, Page 5871-5894, October 2026.
A pharmacological profiling of 58 synthetic stimulants of various classes at dopamine, norepinephrine, and serotonin transporters and the 5‐HT2A receptor, most showing distinct class‐dependent profiles, with some indicating a high abuse potential. Background and Purpose New psychoactive substances (NPSs) often emerge on the illicit drug market with ...
Darta Stalberga, Robert Kronstrand, Bianca Schranz, Nick van Zijl, Sebastian Karlman, Soma Aref, Tobias Rautio, Svante Vikingsson, Mattias Persson, Henrik Green   +9 more
wiley   +1 more source

Durch anomere Amide ermöglichte divergente Synthese unsymmetrischer Harnstoffe, Carbamate, Thioester und Amide aus Aldehyden

Angewandte Chemie, Volume 138, Issue 37, 7 September 2026.
Eine divergente Aldehyd‐Funktionalisierungssequenz, ermöglicht durch ein anomeres Amid, erlaubt den Ein‐Topf‐Zugang zu unsymmetrischen Harnstoffen, Carbamaten, Thiocarbamaten, Thioestern und Amiden. Entscheidend für diese Transformation ist die Bildung von N‐Boc‐Hydroxamat‐Intermediaten, die als Plattformen für eine orthogonale Aktivierung über Lossen ...
Jasper L. Tyler, Meiyi Zeng, Julius Wiener, Marie‐Christin Leusmann, Colin Stein, Constantin G. Daniliuc, Frank Glorius   +6 more
wiley   +1 more source

Anomeric Amide Enabled Divergent Synthesis of Unsymmetrical Ureas, Carbamates, Thioesters, and Amides From Aldehydes

Angewandte Chemie International Edition, Volume 65, Issue 37, 7 September 2026.
An anomeric amide‐enabled divergent aldehyde functionalization sequence provides one‐pot access to unsymmetrical ureas, carbamates, thiocarbamates, thioesters, and amides. Key to this transformation is the formation of N‐Boc‐hydroxamate intermediates, which serve as platforms for orthogonal activation via Lossen‐type rearrangements, single‐electron ...
Jasper L. Tyler, Meiyi Zeng, Julius Wiener, Marie‐Christin Leusmann, Colin Stein, Constantin G. Daniliuc, Frank Glorius   +6 more
wiley   +1 more source

Quantum‐chemical study of the relation between electronic structure and pA2 in a series of 5‐substituted tryptamines [PDF]

, 1985
We have analyzed the dependence of the serotonin receptor binding affinity on the electronic and steric reactivity indexes for a group of 5‐substituted tryptamines.
Saavedra‐Aguilar, J., Rodríguez Gatica, J., Gómez Jeria, Juan, Morales Lagos, D.   +3 more
core   +1 more source

Syntheses and structures of two norpsilocin derivatives: N-ethyl-4-hydroxytryptamine (4-HO-NET) and 4-hydroxy-N-propyltryptamine (4-HO-NPT)

Acta Crystallographica Section E: Crystallographic Communications
The solid-state structures of N-ethyl-4-hydroxytryptamine (4-HO-NET) {systematic name: 3-[2-(ethylamino)ethyl]-1H-indol-4-ol}, C12H16N2O, and 4-hydroxy-N-propyltryptamine (4-HO-NPT) {systematic name: 3-[2-(propylamino)ethyl]-1H-indol-4-ol}, C13H18N2O ...
Marilyn Naeem, Andrew R. Chadeayne, James A. Golen, David R. Manke   +3 more
doaj   +1 more source

Pholiotina cyanopus, a rare fungus producing psychoactive tryptamines

Open Life Sciences, 2014
Pholiotina cyanopus was collected from wood chips and other woody remnants of undetermined tree species. Its basidiomata were found in June within the area of closed sawmill in the central part of Żywiec city (SW Poland).
Halama Marek, Poliwoda Anna, Jasicka-Misiak Izabela, Wieczorek Piotr P., Rutkowski Ryszard   +4 more
doaj   +1 more source