Results 121 to 130 of about 1,269 (154)

Expression of α-tryptase and β-tryptase by human basophils

Journal of Allergy and Clinical Immunology, 2004
Background α and β-Tryptase levels in serum are clinical tools for the evaluation of systemic anaphylaxis and systemic mastocytosis. Basophils and mast cells are known to produce these proteins. Objective The current study examines the effect of the α,β-tryptase genotype on basophil tryptase levels and the type of tryptase stored in these cells ...
Sherryline Jogie-Brahim, Hae-Ki Min, Yoshihiro Fukuoka, Han-Zhang Xia, Lawrence B. Schwartz   +4 more
openaire   +1 more source

Human skin tryptase: purification, partial characterization and comparison with human lung tryptase

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1988
Human skin tryptase was isolated using stepwise low- and high-salt extraction and further purified 448-fold with 33% yield using octyl-Sepharose CL-4B hydrophobic affinity chromatography, Sephacryl S-200 gel filtration and finally octyl-Sepharose CL-4B or cellulose phosphate ion exchange chromatography.
I T, Harvima, N M, Schechter, R J, Harvima, J E, Fräki   +3 more
openaire   +2 more sources

Biomarkers of anaphylaxis, beyond tryptase

Current Opinion in Allergy & Clinical Immunology, 2015
The purpose of this study is to describe the current knowledge regarding mediators involved in anaphylactic reactions, with a special focus on key effector cells and mechanisms.New insight into the potential relevance of pathways other than mast cell degranulation has been unravelled, such as the role of cytokines, platelet activation factor, lipid ...
Anna, Sala-Cunill, Victoria, Cardona
openaire   +2 more sources

Expression of alpha-tryptase and beta-tryptase by human basophils.

The Journal of allergy and clinical immunology, 2004
Alpha and beta-tryptase levels in serum are clinical tools for the evaluation of systemic anaphylaxis and systemic mastocytosis. Basophils and mast cells are known to produce these proteins.The current study examines the effect of the alpha,beta-tryptase genotype on basophil tryptase levels and the type of tryptase stored in these cells.Tryptase ...
Sherryline, Jogie-Brahim, Hae-Ki, Min, Yoshihiro, Fukuoka, Han-Zhang, Xia, Lawrence B, Schwartz   +4 more
openaire   +2 more sources

Tryptase inhibitors: a patent review

Expert Opinion on Therapeutic Patents, 2017
Tryptase is one of the main serine-proteinases located in the secretory granules of mast cells, and is released through degranulation, which is involved in the pathogenesis of allergic inflammatory disease, cardiovascular diseases, lung fibrosis and tumor.
Wei-Wei, Ni, Meng-Da, Cao, Wen, Huang, Ling, Meng, Ji-Fu, Wei   +4 more
openaire   +2 more sources

Serum Concentrations of Tryptase in Children

Pediatric Allergy, Immunology, and Pulmonology, 2014
Background: Mast cells are dispersed in many tissues, especially in digestive and respiratory-tract mucosal membranes. Tryptase, considered a marker of mast-cell activity, is the most important protease released from these cells during degranulation.
Katarzyna, Sznurkowska, Katarzyna, Plata-Nazar, Grażyna, Sikorska-Wiśniewska, Ilona, Gruszczyńska, Joanna, Renke, Marek, Niedoszytko, Jolanta, Gleń, Barbara, Kamińska   +7 more
openaire   +2 more sources

A Role for Tryptase in the Activation of Human Mast Cells: Modulation of Histamine Release by Tryptase and Inhibitors of Tryptase

The Journal of Pharmacology and Experimental Therapeutics, 1998
Tryptase, the most abundant protein product of human mast cells is emerging as an important mediator and target for therapeutic intervention in allergic disease. We have investigated the potential of tryptase and inhibitors of tryptase to modulate histamine release from human mast cells.
S, He, M D, Gaça, A F, Walls
openaire   +2 more sources

Die Co-Tryptase (Enterokinase)

1927
Der spezifische Aktivator der Tryptase, die Enterokinase oder, wie man ihn in Analogie mit den ubrigen Co-Enzymen nennen sollte, die Co-Tryptase, ist nunmehr, besonders durch die Untersuchungen von Waldschmidt-Leitz gut bekannt geworden. Im folgenden wird auf Grund der Arbeiten dieses Forschers uber die wichtigsten Ergebnisse berichtet.
Hans v. Euler, Karl Myrbäck
openaire   +2 more sources

TRYPTASE INHIBITORS

2002
Compounds of formula (I) in which M, B1, B2, R1, R2, R6, R7, K1 and K2 have the meanings indicated in the description are novel active tryptase inhibitors.
ALTANA PHARMA AG, MARTIN THOMAS, ULRICH WOLF-RUEDIGER   +2 more
openaire   +1 more source

Tryptase

1927
Hans v. Euler, Karl Myrbäck
openaire   +2 more sources