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Free Tryptophan in Plasma and Brain Tryptophan Metabolism [PDF]
Nature, 1972 SYNTHESIS in the brain of the putative transmitter 5-hydroxytryptamine (5HT) is influenced by the concentration of tryptophan; the rate limiting step in 5HT synthesis is the hydroxylation of tryptophan1 by tryptophan hydroxylase, which is normally unsaturated with substrate2.
G. Curzon, P. J. Knott
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Tryptophan and Atherosclerosis
1996The association between hypercholesterolemia and atherosclerosis in humans is widely accepted (Goldstein and Brown, 1977; Steinberg, 1983; Nordoy and Goodnight, 1990). Some studies (Muldoon et al., 1990) have shown that a decrease in serum cholesterol in middle-aged subjects by diet, drugs or both, leads to a significant reduction of the incidence of ...
Baldo Enzi G +4 more
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1996
An implication for Serotonin in the pathophysiology of epilepsy has been suggested in experimental and clinical papers.
LUNARDI, GIANLUIGI +6 more
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An implication for Serotonin in the pathophysiology of epilepsy has been suggested in experimental and clinical papers.
LUNARDI, GIANLUIGI +6 more
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The hydroxylation of tryptophan
Archives of Biochemistry and Biophysics, 1992Products of the chemical hydroxylation of tryptophan by Fenton and Udenfriend reactions are similar to those obtained by ionizing radiation. When tryptophan is exposed to either of these systems, a mixture of four hydroxytryptophans, oxindole-3-alanine, and N-formylkynurenine is formed.
Zofia Maskos +2 more
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Psychological Reports, 1997
A measure of tryptophan intake in 30 nations was not associated with their 1980 suicide or homicide rates.
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A measure of tryptophan intake in 30 nations was not associated with their 1980 suicide or homicide rates.
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Activation of the Ah Receptor by Tryptophan and Tryptophan Metabolites
Biochemistry, 1998The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates many of the biological and toxicological actions of a variety of hydrophobic natural and synthetic chemicals, including the environmental contaminant 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin). A variety of indole-containing chemicals, such as indole-3-
Heath-Pagliuso, S. +6 more
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The regulation of tryptophan pyrrolase activity by tryptophan
Advances in Enzyme Regulation, 1966Abstract Tryptophan pyrrolase accumulates in the livers of hydrocortisone-treated rats as the inactive apoenzyme. Treatment with tryptophan activates the apoenzyme by conjugating it with hematin and permitting its conversion to the active, reduced holoenzyme form of tryptophan pyrrolase.
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Tryptophan uptake and tryptophan oxygenase activity in mice
Biochemical and Biophysical Research Communications, 1970Abstract Groups of mice were injected intraperitoneally with L-tryptophan, 1 mg/gm body weight, and maintained at room temperature (22° C) or exposed to acute heat stress (36° C). In the heat-stressed animals, plasma tryptophan levels were lower at each time interval studied when compared with room temperature controls; however, both hepatic ...
Ralph P. Francesconi, Milton Mager
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Specific Enzymatic Chlorination of Tryptophan and Tryptophan Derivatives
1999In the search for an alternative to chemical halogenation reactions using the free halogens, a novel type of halogenating enzymes was detected. In contrast to haloperoxidases, these NADH-dependent halogenases are specific. Tryptophan halogenase which catalyses the regioselective chlorination of tryptophan to 7-chlorotryptophan can also chlorinate ...
Manuela Hölzer, Karl-Heinz van Pée
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Detection of Tryptophan to Tryptophan Energy Transfer in Proteins
The Protein Journal, 2004Förster resonance energy transfer (FRET) studies usually involve observation of intensity or lifetime changes in the donor or acceptor molecule and usually these donor and acceptor molecules differ (heterotransfer). The use of polarization to monitor FRET is far less common, although it was one of the first methods utilized. In 1960, Weber demonstrated
David M. Jameson +2 more
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