Results 151 to 160 of about 1,437,430 (390)

TRYPTOPHAN METABOLISM

, 1949
Charles Heidelberger, Edward P. Abraham, Samuel Lepkovsky   +2 more
openalex   +2 more sources

Mechanoactivated Celite as a Catalyst for C‒H Bond Perfluoroalkylation and Other Radical Reactions

Angewandte Chemie, EarlyView.
Biogenic materials naturally containing trace metals such as Celite or diatomaceous earth promote practical perfluoroalkylation of C─H bonds of (hetero)arenes and a double bond bromination with N‐bromosuccinimide upon mechanoactivation via ball milling. This conceptually broadens the scope of mechanoactivated solids beyond piezoelectric materials. This
Thomas J. Hasiweder, Hoan M. Dinh, Dilip K. Pandey, Aleksandr Sorvanov, Julia R. Khusnutdinova   +4 more
wiley   +2 more sources

The kynurenine pathway in patients with rheumatoid arthritis during tumor necrosis factor α inhibitors treatment

Rheumatology
Objectives The importance of the kynurenine pathway in normal immune system function has led to an appreciation of its possible contribution to autoimmune disorders such as rheumatoid arthritis (RA).
Joanna Witoszyńska-Sobkowiak, Dorota Sikorska, Karolina Niklas, Iwona Żychowska, Rafał Rutkowski, Włodzimierz Samborski   +5 more
doaj   +1 more source

Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset

Advanced Science, EarlyView.
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu, Zhengyuan Zhou, Sascha Schäuble, Wolfgang Vivas, Karen Dlubatz, Michael Bauer, Sebastian Weis, Mervyn Singer, Roman Lukaszewski, Gianni Panagiotou   +9 more
wiley   +1 more source

The microbiota drives diurnal rhythms in tryptophan metabolism in the stressed gut

Cell Reports
Summary: Chronic stress disrupts microbiota-gut-brain axis function and is associated with altered tryptophan metabolism, impaired gut barrier function, and disrupted diurnal rhythms.
Cassandra E. Gheorghe, Sarah-Jane Leigh, Gabriel S.S. Tofani, Thomaz F.S. Bastiaanssen, Joshua M. Lyte, Elisa Gardellin, Ashokkumar Govindan, Conall Strain, Sonia Martinez-Herrero, Michael S. Goodson, Nancy Kelley-Loughnane, John F. Cryan, Gerard Clarke   +12 more
doaj  

A Disturbance of Tryptophan Metabolism in Congenital Hypoplastic Anæmia [PDF]

, 1953
Kurt I. Altman, Gerald Miller
openalex   +1 more source

Tryptophan Metabolism in Man * [PDF]

Journal of Clinical Investigation, 1964
Robert A. Good, Alfred F. Michael, Keith N. Drummond, John A. Anderson, Doris Doeden   +4 more
openaire   +3 more sources

Gut Parabacteroides distasonis‐derived Indole‐3‐Acetic Acid Promotes Phospholipid Remodeling and Enhances Ferroptosis Sensitivity via the AhR‐FASN Axis in Bladder Cancer

Advanced Science, EarlyView.
Indole‐3‐acetic acid (3‐IAA) derived from gut P. distasonis binds to AhR in bladder cancer cells and downregulates FASN transcription, thereby increasing sensitivity to ferroptosis and suppressing the development of bladder tumors. Specifically, 3‐IAA treatment leads to an increase in the proportion of PC/PE‐PUFAs and a decrease in the proportions of ...
Weijia Li, Wentai Shangguan, Wenxue Huang, Jie Zhao, Yuexuan Zhu, Ming Xie, Yao Yu, Qishen Yang, Jun Zheng, Lin Yang, Qi Sun, Leqian Li, Xinhang Shi, Yongyuan Xiao, Hai Huang, Bisheng Cheng, Peng Wu   +16 more
wiley   +1 more source

Covalent Organic Frameworks‐Delivered Reuterin Drives Trained Immunity in Tumor‐Associated Macrophages to Enhance Melanoma Immunotherapy via Glycerophospholipid Metabolism

Advanced Science, EarlyView.
Covalent organic framework (COF)‐reuterin induces trained immunity in tumor‐associated macrophages, promoting the generation of nitric oxide and reactive oxygen species, thereby enhancing the antitumor immune response. Additionally, COF‐Reuterin directly kills tumor cells while simultaneously eradicating pathogenic intratumoural bacteria.
Jian‐Gang Zhang, Xiao‐Mei Zhang, Xi Wu, Cheng‐Kai Zhou, Zhen‐Zhen Liu, Xue‐Yue Luo, Liang Zhang, Wei Chen, Yong‐Jun Yang   +8 more
wiley   +1 more source

The relation between riboflavin and tryptophan metabolism, studied in the rat [PDF]

, 1953
Francine Charconnet-Harding, C. E. Dalgliesh, A. Neuberger   +2 more
openalex   +1 more source