Results 61 to 70 of about 1,437,430 (390)

2014 REU Poster: Measuring Tryptophan Metabolism Using Analogs of Tryptophan [PDF]

, 2014
Poster presentation at REU Summer's End Research Symposium, 2014, by REU participant Thierno Diallo, Roxbury Community College - John "Chip" Celenza group, Sanda Zolj lab mentorNSF ...
Diallo, Thierno
core   +4 more sources

Tryptophan Metabolism and COVID-19-Induced Skeletal Muscle Damage: Is ACE2 a Key Regulator?

Frontiers in Nutrition, 2022
The severity of coronavirus disease 2019 (COVID-19) is characterized by systemic damage to organs, including skeletal muscle, due to excessive secretion of inflammatory cytokines.
H. Takeshita, Koichi Yamamoto
semanticscholar   +1 more source

Serum levels and removal by haemodialysis and haemodiafiltration of tryptophan-derived uremic toxins in ESKD patients [PDF]

, 2020
Tryptophan is an essential dietary amino acid that originates uremic toxins that contribute to end-stage kidney disease (ESKD) patient outcomes.
Adoberg, A, Arduan Ortiz, A, Arund, J, Dhondt, Annemieke, Fernström, A, Fridolin, I, Glorieux, Griet, Gonzales-Parra, E, Leis, L, Luman, M, Paats, J, Perez-Gomez, VM, Pilt, K, Sanchez-Ospina, D, Segelmark, M, Uhlin, F   +15 more
core   +1 more source

Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies

Gut, 2021
Objective Tryptophan can be catabolised to various metabolites through host kynurenine and microbial indole pathways. We aimed to examine relationships of host and microbial tryptophan metabolites with incident type 2 diabetes (T2D), host genetics, diet ...
Q. Qi, Jun Li, B. Yu, Jee-Young Moon, J. Chai, J. Merino, Jieping Hu, M. Ruíz-Canela, C. Rebholz, Zheng Wang, Mykhaylo Usyk, Guo-Chong Chen, Bianca C. Porneala, Wenshuang Wang, N. Q. Nguyen, E. Feofanova, M. Grove, Thomas J. Wang, R. Gerszten, J. Dupuis, J. Salas‐Salvadó, W. Bao, D. Perkins, M. Daviglus, B. Thyagarajan, Jianwen Cai, Tao Wang, J. Manson, M. Martínez-González, E. Selvin, K. Rexrode, C. Clish, F. Hu, J. Meigs, R. Knight, R. Burk, E. Boerwinkle, R. Kaplan   +37 more
semanticscholar   +1 more source

Dietary fibre directs microbial tryptophan metabolism via metabolic interactions in the gut microbiota

Nature Microbiology
Tryptophan is catabolized by gut microorganisms resulting in a wide range of metabolites implicated in both beneficial and adverse host effects. How gut microbial tryptophan metabolism is directed towards indole, associated with chronic kidney disease ...
A. Sinha, M. F. Laursen, Julius E Brinck, Morten L. Rybtke, Anna Pii Hjørne, Nicola Procházková, Mikael Pedersen, H. Roager, Tine R. Licht   +8 more
semanticscholar   +1 more source

Species Differences in Tryptophan Metabolism and Disposition

International Journal of Tryptophan Research, 2022
Major species differences in tryptophan (Trp) metabolism and disposition exist with important physiological, functional and toxicity implications. Unlike mammalian and other species in which plasma Trp exists largely bound to albumin, teleosts and other ...
A. Badawy, G. Guillemin
semanticscholar   +1 more source

ERRFI1 induces apoptosis of hepatocellular carcinoma cells in response to tryptophan deficiency

Cell Death Discovery, 2021
Tryptophan metabolism is an essential regulator of tumor immune evasion. However, the effect of tryptophan metabolism on cancer cells remains largely unknown.
Mingqing Cui, Dan Liu, Wujun Xiong, Yugang Wang, Jun Mi   +4 more
doaj   +1 more source

Aryl hydrocarbon receptor activation by Lactobacillus reuteri tryptophan metabolism alleviates Escherichia coli-induced mastitis in mice

PLoS Pathogens, 2021
The intestinal microbiota has been associated with the occurrence and development of mastitis, which is one of the most serious diseases of lactating women and female animals, but the underlying mechanism has not yet been elucidated.
Caijun Zhao, Xiaoyu Hu, Lijuan Bao, Keyi Wu, Lianjun Feng, Min Qiu, Haoyang Hao, Yunhe Fu, Nai-sheng Zhang   +8 more
semanticscholar   +1 more source

PPARα contributes to protection against metabolic and inflammatory derangements associated with acute kidney injury in experimental sepsis [PDF]

, 2019
Sepsis‐associated acute kidney injury (AKI) is a significant problem in critically ill children and adults resulting in increased morbidity and mortality. Fundamental mechanisms contributing to sepsis‐associated AKI are poorly understood.
Bennion, Brock G, Djukovic, Danijel, Fei, Lin, Iwaki, Takuma, Liles, W. Conrad, Lynn, Jared C, Otinga, Cynthia, Raftery, Daniel, Standage, Stephen W, Stenson, Erin K, Wong, Hector R   +10 more
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Alterations in tryptophan metabolism and de novo NAD+ biosynthesis within the microbiota-gut-brain axis in chronic intestinal inflammation

Frontiers in Medicine
BackgroundInflammatory bowel disease is an incurable and idiopathic disease characterized by recurrent gastrointestinal tract inflammation. Tryptophan metabolism in mammalian cells and some gut microbes comprise intricate chemical networks facilitated by
Jeannie Devereaux, Ainsley M. Robinson, Ainsley M. Robinson, Ainsley M. Robinson, Rhian Stavely, Rhian Stavely, Majid Davidson, Narges Dargahi, Ramya Ephraim, Dimitros Kiatos, Vasso Apostolopoulos, Vasso Apostolopoulos, Vasso Apostolopoulos, Kulmira Nurgali, Kulmira Nurgali, Kulmira Nurgali   +15 more
doaj   +1 more source