Results 111 to 120 of about 29,860 (247)

TFEB Orchestrates Stress Recovery and Paves the Way for Senescence Induction in Human Dermal Fibroblasts

Aging Cell, Volume 24, Issue 7, July 2025.
TFEB dynamics during oxidative stress‐induced premature senescence. The tBHP treatment undermines GSH‐dependent antioxidant mechanisms, leading to increased ROS production and lysosomal damage. In the stress phase, we observed the concomitant inhibition of Akt along with activation of AMPK, together leading to mTOR inhibition and subsequent ...
Lena Guerrero‐Navarro, Pablo Monfort‐Lanzas, Vinzenz Krichbaumer, Mariana E. G. De Araújo, Jlenia Monfregola, Lukas A. Huber, Andrea Ballabio, Pidder Jansen‐Dürr, Maria Cavinato   +8 more
wiley   +1 more source

Tuberous Sclerosis Complex Activity Is Required to Control Neuronal Stress Responses in an mTOR-Dependent Manner [PDF]

, 2009
Tuberous Sclerosis Complex (TSC) is a neurogenetic disorder caused by loss-of-function mutations in either the TSC1 or TSC2 genes and frequently results in prominent CNS manifestations including epilepsy, mental retardation, and autism spectrum disorder.
Cho, Namjik, Di Nardo, Alessia, Kramvis, Ioannis, Kwiatkowski, David J., Meikle, Lynsey, Sadowski, Abbey, Sahin, Mustafa   +6 more
core   +1 more source

Diagnostic accuracy and clinical outcomes of patients diagnosed with clear cell papillary renal cell tumour at renal mass biopsy

Histopathology, Volume 87, Issue 1, Page 138-144, July 2025.
Clear cell papillary renal cell tumours can be identified on renal mass biopsy if strict morphologic and immunohistochemical criteria are used. We found a high concordance between the biopsy and resection diagnoses of these tumours and that patients treated nonsurgically had favourable clinical outcomes.
Alexander Oberc, Carol C Cheung, Satheesh Krishna, Antonio Finelli, Susan Prendeville   +4 more
wiley   +1 more source

Successful Treatment of Growing Renal Angiomyolipomas With Low‐Dose Everolimus in a School‐Aged Child With Tuberous Sclerosis Complex

Nephrology, Volume 30, Issue 7, July 2025.
ABSTRACT Renal angiomyolipomas (AMLs) are a common renal manifestation in tuberous sclerosis complex (TSC), occurring in 50%–85% of cases. Even in asymptomatic individuals, treatment is often initiated based on AML size, with mTOR inhibitors being the primary medical therapy.
Satoshi Senoo, Shoichiro Kanda, Keiichi Takizawa, Hiroshi Terashima, Yuko Kajiho, Yutaka Harita   +5 more
wiley   +1 more source

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR [PDF]

, 2003
Hongbing Zhang, Gregor Cicchetti, Hiroaki Onda, Henry Koon, Kirsten Asrican, Natalia Bajraszewski, Francisca Vázquez, Christopher L. Carpenter, David J. Kwiatkowski   +8 more
openalex   +2 more sources

A brain proteomic investigation of rapamycin effects in the Tsc1 +/− mouse model

Molecular Autism, 2017
Background Tuberous sclerosis complex (TSC) is a rare monogenic disorder characterized by benign tumors in multiple organs as well as a high prevalence of epilepsy, intellectual disability and autism.
Hendrik Wesseling, Ype Elgersma, Sabine Bahn   +2 more
doaj   +1 more source

The temporal dynamics of calibration target reflectance

, 2003
A field experiment investigated the hypothesis that the nadir reflectance of calibration surface substrates (asphalt and concrete) remains stable over a range of time-scales.
Anderson, K., Milton, E.J., Rollin, E.M.
core  

Identification of markers flanking the tuberous sclerosis locus on chromosome 9 (TSC1). [PDF]

, 1993
Mark Nellist, Phillip T. Brook-Carter, J. M. Connor, D J Kwiatkowski, Peter Johnson, Julian R. Sampson   +5 more
openalex   +1 more source

Identification of a complex intrachromosomal inverted insertion in the long arm of chromosome 9 as a cause of tuberous sclerosis complex in a Korean family

Molecular Genetics & Genomic Medicine
Background Tuberous sclerosis complex (TSC) is an autosomal dominant multisystem disorder, caused by a loss‐of‐function of either TSC1 or TSC2 gene. However, in 10%–15% TSC patients there is no pathogenic variant identified in either TSC1 or TSC2 genes ...
Seung Woo Ryu, Ji‐Hee Yoon, Dong‐wook Kim, Beomman Han, Heonjong Han, Joohyun Han, Hane Lee, Go Hun Seo, Beom Hee Lee   +8 more
doaj   +1 more source

Comprehensive Mutation Analysis of TSC1 and TSC2—and Phenotypic Correlations in 150 Families with Tuberous Sclerosis [PDF]

, 1999
Alistair C. Jones, Magitha M. Shyamsundar, Meinir W. Thomas, Julie Maynard, Shelley Idziaszczyk, Susan Tomkins, Julian R. Sampson, Jeremy P. Cheadle   +7 more
openalex   +1 more source