Results 141 to 150 of about 29,860 (247)

Association of TSC1/Hamartin, 14-3-3σ, and p27 Expression With Tumor Outcomes in Patients With pTa/pT1 Urothelial Bladder Carcinoma [PDF]

, 2008
Paulette Mhawech‐Fauceglia, Victor E. Alvarez, Gabor Fischer, Amy Beck, François R. Herrmann   +4 more
openalex   +1 more source

Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1 [PDF]

, 2009
Jing Zhou, James Brugarolas, Luis F. Parada   +2 more
openalex   +1 more source

Activation of mTORC1 in chondrocytes does not affect proliferation or differentiation, but causes the resting zone of the growth plate to become disordered

Bone Reports, 2018
There are several pitfalls associated with research based on transgenic mice. Here, we describe our interpretation and analysis of mTORC1 activation in growth plate chondrocytes and compare these to a recent publication (Yan et al., Nature Communications
Phillip T. Newton, Meng Xie, Ekaterina V. Medvedeva, Lars Sävendahl, Andrei S. Chagin   +4 more
doaj  

Postnatal neurogenesis generates heterotopias, olfactory micronodules and cortical infiltration following single-cell Tsc1 deletion [PDF]

, 2011
David M. Feliciano, Jennifer L. Quon, Tong Su, M. Morgan Taylor, Angélique Bordey   +4 more
openalex   +1 more source

Promoter characterization of the TSC1 gene

, 2003
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder with loci on chromosome 9q34 (TSC1) and chromosome 16p13 (TSC2). Genes for both loci have been isolated and characterized. The promoters of both genes have not been characterized so far and little is known about the regulation of these genes.
Ali, Mahmood, Girimaji, SC, Kumar, Arun
openaire   +1 more source

Identification of a novel TSC1 gene variant in a patient with atypical vitiligo‐like skin lesions: Unveiling the hidden tuberous sclerosis complex

Molecular Genetics & Genomic Medicine
Background Tuberous sclerosis complex (TSC), an autosomal‐dominant disorder, is characterized by hamartomas affecting multiple organ systems. The underlying etiology of TSC is the pathogenic variations of the TSC1 or TSC2 genes. The phenotype variability
Linli Liu, Yanbo Wang, Zhengzhong Zhang, Chunshui Yu, Jin Chen   +4 more
doaj   +1 more source

Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex [PDF]

, 2011
June Goto, Delia M. Talos, Peter Klein, Wei Qin, Yvonne Chekaluk, Stefanie Anderl, Izabela A. Malinowska, Alessia Di Nardo, Roderick T. Bronson, Jennifer A. Chan, Harry V. Vinters, Steven G. Kernie, Frances E. Jensen, Mustafa Şahin, David J. Kwiatkowski   +14 more
openalex   +1 more source

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

, 2003
Attila Garami, Fried Zwartkruis, Takahiro Nobukuni, Manel Joaquin, Marta Roccio, Hugo Stocker, Sara C. Kozma, Ernst Hafen, Johannes L. Bos, George Thomas   +9 more
openalex   +1 more source

Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1

Molecular Therapy: Methods & Clinical Development, 2019
Tuberous sclerosis complex (TSC) is a tumor suppressor syndrome caused by mutations in TSC1 or TSC2, encoding hamartin and tuberin, respectively. These proteins act as a complex that inhibits mammalian target of rapamycin (mTOR)-mediated cell growth and ...
Shilpa Prabhakar, Pike See Cheah, Xuan Zhang, Max Zinter, Maria Gianatasio, Eloise Hudry, Roderick T. Bronson, David J. Kwiatkowski, Anat Stemmer-Rachamimov, Casey A. Maguire, Miguel Sena-Esteves, Bakhos A. Tannous, Xandra O. Breakefield   +12 more
doaj  

The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function [PDF]

, 2011
Kai Yang, Geoffrey Neale, Douglas R. Green, Weifeng He, Hongbo Chi   +4 more
openalex   +1 more source