Results 71 to 80 of about 29,860 (247)

Differential Expression of MicroRNA-19b Promotes Proliferation of Cancer Stem Cells by Regulating the TSC1/mTOR Signaling Pathway in Multiple Myeloma

Cellular Physiology and Biochemistry, 2018
Background/Aims: MiR-19b has been reported to be involved in several malignancies, but its role in multiple myeloma (MM) is still unknown. The objective of this study was to explore the biological mechanism of miR-19b in the progression of MM.
Ni Wang, Xiaohua Liang, Weijian Yu, Shihang Zhou, Meiyun  Fang   +4 more
doaj   +1 more source

TSC1 controls macrophage polarization to prevent inflammatory disease [PDF]

Nature Communications, 2014
Macrophages acquire distinct phenotypes during tissue stress and inflammatory responses, but the mechanisms that regulate the macrophage polarization are poorly defined. Here we show that tuberous sclerosis complex 1 (TSC1) is a critical regulator of M1 and M2 phenotypes of macrophages.
Tao Yang, Lianjun Zhang, Yong Zhao, Jianxia Peng, Hongbing Zhang, Longjie Li, Qingjie Zhao, Xuelian Hu, Yuzhu Hou, Zhongzhou Yang, Ruoyu Wang, Linnan Zhu, Lianfeng Zhang, Hongling Tian, Lina Sun   +14 more
openaire   +2 more sources

Tumour Cell Size Control and Its Impact on Tumour Cell Function

Cell Proliferation, EarlyView.
The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
wiley   +1 more source

A Novel Hap1-Tsc1 interaction regulates neuronal mTORC1 signaling and morphogenesis in the brain [PDF]

, 2013
Tuberous sclerosis complex (TSC) is a leading genetic cause of autism. The TSC proteins Tsc1 and Tsc2 control the mTORC1 signaling pathway in diverse cells, but how the mTORC1 pathway is specifically regulated in neurons remains to be elucidated.
Bennett, Eric J, Bonni, Azad, Harper, J. Wade, Ikeuchi, Yoshiho, Litterman, Nadia, Mejia, Luis A, Torre-Ubieta, Luis de la, Zhang, Chi   +7 more
core   +2 more sources

Medication‐resistant epilepsy is associated with a unique gut microbiota signature

Epilepsia, Volume 66, Issue 7, Page 2268-2284, July 2025.
Abstract Objective Dysfunction of the microbiota–gut–brain axis is emerging as a new pathogenic mechanism in epilepsy, potentially impacting on medication response and disease outcome. We investigated the composition of the gut microbiota in a cohort of medication‐resistant (MR) and medication‐sensitive (MS) pediatric patients with epilepsy.
Antonella Riva, Eray Sahin, Greta Volpedo, Noemi Teresa Catania, Isabel Venara, Valentina Biagioli, Ganna Balagura, Elisabetta Amadori, Carmen De Caro, Emanuele Cerulli Irelli, Carlo Di Bonaventura, Federico Zara, Osman Ugur Sezerman, Emilio Russo, Pasquale Striano   +14 more
wiley   +1 more source

Tsc1Haploinsufficiency without Mammalian Target of Rapamycin Activation Is Sufficient for Renal Cyst Formation inTsc1+/− Mice [PDF]

Cancer Research, 2006
AbstractTuberous sclerosis complex (TSC) is caused by mutations in either the TSC1 or TSC2 gene. Both genes are generally considered to act as tumor suppressors that fulfill Knudson's “two-hit hypothesis” and that function within the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin (mTOR) pathway.
Cleo Bonnet, Julie Helen Maynard, James Colley, Catherine H. Wilson, Carol Guy, Jeremy Peter Cheadle, Julian R. Sampson, Shelley Idziaszczyk, Vikki Humphreys   +8 more
openaire   +3 more sources

TSC1 Affects the Process of Renal Ischemia-Reperfusion Injury by Controlling Macrophage Polarization

Frontiers in Immunology, 2021
Renal ischemia-reperfusion injury (IRI) contributes to acute kidney injury (AKI), increases morbidity and mortality, and is a significant risk factor for chronic kidney disease (CKD).
Xiao Hu, Xiao Hu, Yanan Xu, Yanan Xu, Zhaoqi Zhang, Zhaoqi Zhang, Zuofu Tang, Jinhua Zhang, You Luo, Weiming Deng, Zhanwen Dong, Yong Zhao, Yong Zhao, Yong Zhao, Ning Na   +14 more
doaj   +1 more source

Cellular antiseizure mechanisms of everolimus in pediatric tuberous sclerosis complex, cortical dysplasia, and non-mTOR-mediated etiologies. [PDF]

, 2018
The present study was designed to examine the potential cellular antiseizure mechanisms of everolimus, a mechanistic target of rapamycin (mTOR) pathway blocker, in pediatric epilepsy cases. Cortical tissue samples obtained from pediatric patients (n 
Barry, Joshua, Cepeda, Carlos, Fallah, Aria, Levine, Michael S, Levinson, Simon, Mathern, Gary W, Vinters, Harry V, Wu, Joyce Y, Yazon, Vannah-Wila   +8 more
core   +2 more sources

Expanding the therapeutic role of highly purified cannabidiol in monogenic epilepsies: A multicenter real‐world study

Epilepsia, Volume 66, Issue 7, Page 2253-2267, July 2025.
Abstract Objective This real‐world, retrospective, multicenter study aims to investigate the effectiveness of highly purified cannabidiol (CBD) in a large cohort of patients with epilepsy of genetic etiology due to an identified monogenic cause. Additionally, we examine the potential relationship between specific genetic subgroups and treatment ...
Emanuele Cerulli Irelli, Adolfo Mazzeo, Roberto H. Caraballo, Marco Perulli, Patrick B. Moloney, Javier Peña‐Ceballos, Marica Rubino, Katarzyna M. Mieszczanek, Andrea Santangelo, Laura Licchetta, Valentina De Giorgis, Gabriela Reyes Valenzuela, Susanna Casellato, Elisabetta Cesaroni, Francesca F. Operto, Jana Domínguez‐Carral, Alia Ramírez‐Camacho, Alessandro Ferretti, Giuseppe Santangelo, Angel Aledo‐Serrano, Andrea Rüegger, Maria M. Mancardi, Giulia Prato, Antonella Riva, Luca Bergonzini, Duccio M. Cordelli, Paolo Bonanni, Francesca Bisulli, Giancarlo Di Gennaro, Sara Matricardi, Pasquale Striano, Norman Delanty, Carla Marini, Domenica Battaglia, Carlo Di Bonaventura, Georgia Ramantani, Elena Gardella, GENE‐CBD Study Group, Alessandro Orsini, Antonietta Coppola, Alessandra Morano, Nicola Simeone, Claudia Cuccurullo, Massimo Scacciati, Alice Bonuccelli, Maddalena Bianchetti, Alberto Verrotti, Marta Piccioli, Massimiliano Celario, Elena Tartara, Giulia Balletto, Chiara Bagliani, Beatriz Gonzalez Giraldez, Pasquale Parisi, Carmen Salluce, Emanuele Bartolini, Maria Del Carmen Fons‐Estupiña, Federico Ramos, Alberto Danieli, Alessandra Rossi, Elisabetta Pantaloni, Ana Laura Fernandez‐Perrone, Giorgio Magli, Ilaria Onida, Giulia Bruschi, Lorenzo Muccioli, Tomasz S. Mieszczanek, Trine Hammer, Francesca Furia   +68 more
wiley   +1 more source

TSC1 regulates the balance between effector and regulatory T cells [PDF]

Journal of Clinical Investigation, 2013
Mammalian target of rapamycin (mTOR) plays a crucial role in the control of T cell fate determination; however, the precise regulatory mechanism of the mTOR pathway is not fully understood. We found that T cell-specific deletion of the gene encoding tuberous sclerosis 1 (TSC1), an upstream negative regulator of mTOR, resulted in augmented Th1 and Th17 ...
Yoon Park, Masako Murai, Mitchell Kronenberg, Chris Elly, Hyung-seung Jin, Gisen Kim, Yun-Cai Liu, Justine Lopez   +7 more
openaire   +3 more sources