Results 131 to 140 of about 37,863 (256)
Histopathology, Volume 88, Issue 3, Page 698-709, February 2026.We evaluated the diagnostic utility of GPNMB immunohistochemistry in LAM. GPNMB showed strong expression in LAM cells, while the differential diagnostic mimics showed no or only low expression. Based on its 100% sensitivity and specificity in our cohort, GPNMB is a highly reliable immunohistochemical marker for the diagnosis of LAM.
Fatime Szalai +6 more
wiley +1 more source
Supplementary Figure 1 from c-myc Repression of <i>TSC2</i> Contributes to Control of Translation Initiation and Myc-Induced Transformation [PDF]
, 2023 Michael J. Ravitz +3 more
openalex +2 more sources
The FASEB Journal, Volume 40, Issue 1, 15 January 2026.This study reveals that the long non‐coding RNA DANCR drives pathological retinal neovascularization in oxygen‐induced retinopathy via an ANXA2‐dependent p38/MAPK/mTOR autophagy pathway. In hypoxic endothelial cells and a murine OIR model, DANCR promotes angiogenesis.
Yini Wang, Jiale Bai, Shihong Zhao
wiley +1 more source
Cell Reports, 2016 Hyperfunction of the mTORC1 pathway has been associated with idiopathic and syndromic forms of autism spectrum disorder (ASD), including tuberous sclerosis, caused by loss of either TSC1 or TSC2. It remains largely unknown how developmental processes and
Veronica Costa +22 more
doaj +1 more source
Toward chemotherapy for Tsc2-mutant renal tumor.
Proceedings of the Japan Academy, Series B, 2003 Recent genetic studies of Drosophila melanogaster and subsequent biochemical analysis in mammalian cells revealed that products of tuberous sclerosis genes, TSC1 and TSC2, regulate insulin signaling via suppression of p70 ribosomal S6 subunit-kinase (S6K) activity.
Toshiyuki KOBAYASHI +4 more
openaire +2 more sources
Supplementary Figure 6 from Macrophage-Induced Tumor Angiogenesis Is Regulated by the TSC2–mTOR Pathway [PDF]
, 2023 Wei Chen +6 more
openalex +2 more sources
TSC2 modulates cell adhesion and migration via integrin-α1β1
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2012 Recent evidence suggests that the rare and progressive lung disease lymphangioleiomyomatosis (LAM) is metastatic in nature. Dysfunction of the tumor suppressor genes tuberous sclerosis complex (TSC), in particular mutational inactivation of TSC2, enhances both cell proliferation and migration.
Lyn M, Moir +2 more
openaire +3 more sources
Determinants of Business Cycle Comovement: A Robust Analysis [PDF]
This paper investigates the determinants of business cycle comovement between countries. Our dataset includes over 100 countries, both developed and developing.
Marianne Baxter, Michael A. Kouparitsas
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