Results 111 to 120 of about 25,325 (232)

Heterozygous Tsc2 (Tsc2+/–) mouse model to study induced renal cancer in response to ionizing radiation at low doses

Carcinogenesis, 2018
Abstract Kidneys are one of the main dose-limiting organs in radiotherapeutic procedures of lower abdomen. Likewise, the threat of exposure of radiosensitive organs such as kidneys in warfare or radiation accidents among military personal or due to terrorist activities in general public is of increasing concern.
Sureshkumar M A, Caroline R Delma, Krishnan Manickam, Sumathy Mohan, Samy L Habib, Mohan Natarajan   +5 more
openaire   +2 more sources

Nutrient Sensing and Growth Control in Plasmodium: Beyond mTOR Signaling

Molecular Microbiology, EarlyView.
Plasmodium parasites lack the canonical mTOR kinase and associated signaling complexes, yet retain key mTOR‐like functions. Parasite‐specific nutrient sensors, kinases, and translational regulators coordinate growth, stress adaptation, metabolic plasticity, and developmental decisions through a distributed regulatory network.
Felix Müller, Gabriele Pradel
wiley   +1 more source

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source

TSC2 is a stress granule suppressor

ABSTRACT Stress granules (SGs) are dynamic, membrane-less ribonucleoprotein assemblies that form through liquid-liquid phase separation to prioritize stress-survival proteostasis. Through reanalysis of a Drosophila genome-wide RNAi screen, we identified a set of conserved SG ...
Yizhe Ma, Natalie G. Farny
openaire   +1 more source

Phenotype reversion of human TSC2-/- smooth muscle cells

, 2007
Tuberous sclerosis complex (TSC) is a tumor suppressor gene syndrome resulting from the loss of function of the hamartin/tuberin complex. Two genes are implicated in TSC, TSC1 and TSC2, respectively encoding hamartin and tuberin.
V. Grande, E. Isaia, E. Lesma, A.M. Di Giulio, A. Gorio   +4 more
core   +2 more sources

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

The role of TSC1 and TSC2 proteins in neuronal axons

Molecular Psychiatry
Tuberous Sclerosis Complex 1 and 2 proteins, TSC1 and TSC2 respectively, participate in a multiprotein complex with a crucial role for the proper development and function of the nervous system. This complex primarily acts as an inhibitor of the mechanistic target of rapamycin (mTOR) kinase, and mutations in either TSC1 or TSC2 cause a ...
Vasiliki Karalis, Delaney Wood, Nicole A. Teaney, Mustafa Sahin   +3 more
openaire   +2 more sources

Sleep Disturbances in Adults With Tuberous Sclerosis Complex: Influences of Treatment and Clinical Features

American Journal of Medical Genetics Part A, Volume 200, Issue 11, Page 2454-2463, November 2026.
ABSTRACT Tuberous sclerosis complex (TSC) is a genetic condition with multisystem neurocutaneous signs, including hamartomas, epilepsy, and neuropsychological difficulties. Although sleep disorders are increasingly recognized in TSC, they remain poorly described in adults.
Kirstin A. Risgaard, Laura Farach, Hope Northrup, Sarah L. Wilson, Deborah Pearson, Syed Hashmi, Kate Richardson   +6 more
wiley   +1 more source

Effects of TSC1 and TSC2 on actin cytoskeleton.

, 2014
A: F-actin staining of serum-deprived NIH 3T3 fibroblasts and matched Tsc1+/+, Tsc1−/− and Tsc2+/+, and Tsc2−/− MEFs. B: F-actin staining (red) of Tsc1−/− and Tsc2−/− MEFs transfected with either GFP-TSC1, GFP-TSC2, or GFP.
Melane L. James (652653), Dmitry A. Goncharov (652655), Vera P. Krymskaya (188111), Tatiana V. Kudryashova (652654), Elena A. Goncharova (300148)   +4 more
core   +1 more source