Results 111 to 120 of about 23,999 (238)
Neonatal Seizures in Tuberous Sclerosis Complex: A Case Series
Annals of the Child Neurology Society, Volume 4, Issue 2, Page 145-149, June 2026.ABSTRACT Background Epilepsy affects up to 90% of patients with tuberous sclerosis complex (TSC); earlier seizure onset is associated with worse neurocognitive outcomes. The incidence of neonatal seizures in TSC is unknown, although in a recent multicenter trial 23% of infants with TSC were excluded prior to randomization because of pre‐existing ...
Kristina Jülich, Kristen Arredondo
wiley +1 more source
TSC1 and TSC2 gene expression regulation in the mTORC1 pathway [PDF]
O complexo da esclerose tuberosa (TSC, do inglês, tuberous sclerosis complex) é uma doença sistêmica, caracterizada por tumores benignos em diferentes órgãos e causada por variantes patogênicas nos genes supressores de tumores TSC1 ou TSC2.
Conceição, Fábio Arthur Mateus
core +1 more source
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Hannah Zillikens +15 more
wiley +1 more source
Roles of long non‐coding RNAs in gestational diabetes mellitus: Mechanisms and biomarker potential
Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.Upregulated lncRNAs in GDM Some key lncRNAs (MALAT1, MEG8, SOX2OT and …) show higher expression in GDM. Downregulated lncRNAs in GDM Some key lncRNAs (HCG27, GASS, Pax AS1 and …) show lower expression in GDM. Mechanistic roles lncRNAs regulate trophoblast proliferation, insulin signalling, neonatal and offspring health and other complications related ...
Reza Kouchaki +8 more
wiley +1 more source
Regulation of IRS2 and TSC2 by KLF4.
, 2018 (a) Strong correlation of expression patterns of KLF4, IRS2 and TSC2 across different conditions (DC8, DW8, DC16, DW16), but little correlation with expression of the negative control gene, MTAP1B, across the different conditions.
Annamalai Muthiah (5778263) +4 more
core +1 more source
Cell Reports, 2016 Hyperfunction of the mTORC1 pathway has been associated with idiopathic and syndromic forms of autism spectrum disorder (ASD), including tuberous sclerosis, caused by loss of either TSC1 or TSC2. It remains largely unknown how developmental processes and
Veronica Costa +22 more
doaj +1 more source
Epilepsia, Volume 67, Issue 6, Page 3108-3121, June 2026.Abstract Objective A strong bidirectional relationship exists between epilepsy and sleep, with seizures often occurring more frequently in sleep and, in turn, sleep being disrupted by seizures. However, the mechanistic basis of seizure–sleep interactions is poorly understood.
Nicholas R. Rensing +4 more
wiley +1 more source
, 2013 Tuberous sclerosis complex (TSC) is a multi-systemic syndrome caused by mutations in TSC1 or TSC2 gene. In TSC2-null cells, Rheb, a member of the Ras family of GTPases, is constitutively activated.
S. Ancona +5 more
core +1 more source
Hydrological Processes, Volume 40, Issue 6, June 2026.Temperature with depth measurements were used to model heat transport associated with sub‐daily changes in bidirectional hydrological fluxes. Tidal pumping along the shoreline, of alternating patterns of tidal intrusion during high tide and groundwater discharge during low tide, was modelled using a recursive estimation state‐space model.
Henry E. Moore +9 more
wiley +1 more source
The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies
MedComm – Oncology, Volume 5, Issue 2, June 2026.Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao +4 more
wiley +1 more source