Results 101 to 110 of about 23,999 (238)

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

Comparison of the functional and structural characteristics of rare TSC2 variants with clinical and genetic findings [PDF]

, 2019
The TSC1 and TSC2 gene products interact to form the tuberous sclerosis complex (TSC), an important negative regulator of the mechanistic target of rapamycin complex 1 (TORC1). Inactivating mutations in TSC1 or TSC2 cause TSC, and the identification of a
Kümmel, D. (Daniel), Ekong, R. (Rosemary), Nellist, M.D. (Mark), Zonta, A. (Andrea), Hosseinzadeh, M. (Mitra), Kenter, A.T. (Annegien), Kom-Gortat, R. (Regina), Migone, N. (Nicola), Schaaf, G. (Gerben), Povey, S. (Sue), Dufner de Almeida, L.G. (Luiz), Elfferich, P.C., Nanhoe, S. (Santoesha)   +12 more
core   +1 more source

ASPSCR1: TFE3 Fusion‐Positive Epithelioid Angiomyolipoma/PEComa Lacking Melanocytic Markers: A Case Report

IJU Case Reports, Volume 9, Issue 4, July 2026.
ABSTRACT Introduction Epithelioid angiomyolipoma is a rare perivascular epithelioid cell tumor subtype with malignant potential. Its morphology mimics renal cell carcinoma, posing diagnostic challenges. Half of these cases harbor TSC1/TSC2 alterations, and a small subset features TFE3 rearrangements, mutually exclusive of TSC mutations.
Yuka Kondo, Yoji Nagashima, Kenji Zennami, Megumi Sato, Sayaka Sumiyoshi, Akihiko Sugimoto, Madoka Isomura, Kiyoshi Takahara, Sachiko Minamiguchi   +8 more
wiley   +1 more source

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.

, 2009
BackgroundThe signaling pathways imposing hormonal control over adipocyte differentiation are poorly understood. While insulin and Akt signaling have been found previously to be essential for adipogenesis, the relative importance of their many downstream
Huang Jingxiang, Brendan D. Manning, Manning Brendan D., Huang J., Squillance R.M., Zhang Hui H., Jingxiang Huang, Hui H. Zhang, Düvel Katrin, Squillace Rachel M., Düvel K., Katrin Düvel, Bernard Boback, Rachel M. Squillace, Wu Shulin, Chin-Lee Wu, Wu S., Wu C.-L., Brendan D Manning, Shulin Wu, Zhang H.H., Hui H Zhang, Boback B., Rachel M Squillace, Manning B.D., Boback Bernard, Wu Chin-Lee   +26 more
core   +1 more source

Comparison of three rapamycin dosing schedules in A/J Tsc2^+/- mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice with subcutaneous tuberous sclerosis related tumors

Journal of Translational Medicine, 2010
Background Tuberous Sclerosis Complex (TSC) is an autosomal dominant tumor disorder characterized by the growth of hamartomas in various organs including the kidney, brain, skin, lungs, and heart.
Dabora Sandra L, Nobil Alison, Woodrum Chelsey   +2 more
doaj   +1 more source

Late‐Onset Diagnosis of Tuberous Sclerosis Complex Revealed by Renal Angiomyolipoma: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Tuberous sclerosis complex (TSC) is a rare autosomal dominant disorder characterized by multisystem hamartomas caused by pathogenic variants in TSC1 or TSC2. It is typically diagnosed in childhood, most often because of neurological or dermatological manifestations.
A. Fekih, W. Heni, C. Messaoudi, Y. Selmi, D. Touati, Z. Elloumi, J. Labidi   +6 more
wiley   +1 more source

Effects of TSC1 and TSC2 on actin cytoskeleton.

, 2014
A: F-actin staining of serum-deprived NIH 3T3 fibroblasts and matched Tsc1+/+, Tsc1−/− and Tsc2+/+, and Tsc2−/− MEFs. B: F-actin staining (red) of Tsc1−/− and Tsc2−/− MEFs transfected with either GFP-TSC1, GFP-TSC2, or GFP.
Melane L. James (652653), Dmitry A. Goncharov (652655), Vera P. Krymskaya (188111), Tatiana V. Kudryashova (652654), Elena A. Goncharova (300148)   +4 more
core   +1 more source

mTOR/miR-142-3p/PRAS40 signaling cascade is critical for tuberous sclerosis complex-associated renal cystogenesis

Cellular & Molecular Biology Letters
Background Patients with tuberous sclerosis complex (TSC) develop renal cysts and/or angiomyolipomas (AMLs) due to inactive mutations of either TSC1 or TSC2 and consequential mTOR hyperactivation.
Shuyun Zhao, Shuai Hao, Jiasheng Zhou, Xinran Chen, Tianhua Zhang, Zhaolai Qi, Ting Zhang, Sajid Jalal, Chuanxin Zhai, Lu Yin, Yufei Bo, Hongming Teng, Yue Wang, Dongyan Gao, Hongbing Zhang, Lin Huang   +15 more
doaj   +1 more source