Results 101 to 110 of about 25,325 (232)

Out of the Ordinary, but Not Out of the Question: Atypia in Pancreatic Lesions Is Not Always Carcinoma

Cytopathology, EarlyView.
An incidental pancreatic lesion in a 69‐year‐old woman was sampled by EUS‐guided fine‐needle biopsy. Integrated cytopathological and histopathological evaluation with immunochemical staining supported organ‐preserving surgery. ABSTRACT Pancreatic perivascular epithelioid cell tumours (PEComas) are exceptionally rare mesenchymal neoplasms.
Maja Kebe Radulovic, Branislava Rankovic, Ajda Toni, Margareta Zlajpah, Darko Siuka   +4 more
wiley   +1 more source

Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid, Peter G. Hains, Velda X. Han, Jingya Yan, Michael Griffiths, Ignatius Pang, Sushil Bandodkar, Phillip J. Robinson, Russell C. Dale   +8 more
wiley   +1 more source

TSC2 Modulates Actin Cytoskeleton and Focal Adhesion Through TSC1-Binding Domain and the Rac1 GTPase [PDF]

, 2004
Tuberous sclerosis complex (TSC) 1 and TSC2 are thought to be involved in protein translational regulation and cell growth, and loss of their function is a cause of TSC and lymphangioleiomyomatosis (LAM).
Goncharov, Dmitry, Elena Goncharova, Goncharova, Elena, Noonan, Daniel J., Vera P. Krymskaya, Dmitry Goncharov, Daniel Noonan, Krymskaya, Vera P   +7 more
core   +1 more source

Reversion of the phenotype of human TSC2-/- smooth muscle cells

, 2007
Tuberous sclerosis complex (TSC) is a inheritable genetic disorder characterized by the development of hamartomas, which are unusual tumor-like growth found in a variety of tissues and organs.
V. Grande, E. Isaia, E. Lesma, A.M. Di Giulio, A. Gorio   +4 more
core   +2 more sources

Abnormal Neural Progenitor Cells Differentiated from Induced Pluripotent Stem Cells Partially Mimicked Development of TSC2 Neurological Abnormalities

Stem Cell Reports, 2017
Summary: Tuberous sclerosis complex (TSC) is a disease featuring devastating and therapeutically challenging neurological abnormalities. However, there is a lack of specific neural progenitor cell models for TSC.
Yaqin Li, Jiqing Cao, Menglong Chen, Jing Li, Yiming Sun, Yu Zhang, Yuling Zhu, Liang Wang, Cheng Zhang   +8 more
doaj   +1 more source

Clinicopathological and molecular comparison of eosinophilic solid and cystic renal cell carcinoma and TFEB‐amplified renal cell carcinoma: a comprehensive study of 15 cases

Histopathology, EarlyView.
This study supports the need for ancillary testing to diagnose ESC‐RCC versus TFEB‐amplified RCC, as neither morphology nor immunohistochemistry is sufficiently specific to distinguish these entities. The underlying molecular drivers in each tumour are pathogenic TSC1 or TSC2 gene variants in ESC‐RCC and TFEB gene amplification in TFEB‐amplified RCC ...
Hayley Zullow, Melissa Y. Tjota, Jung Woo Kwon, Tatjana Antic   +3 more
wiley   +1 more source

TACC3-TSC2 maintains nuclear envelope structure and controls cell division.

, 2010
International audienceStudies of the role of tuberous sclerosis complex (TSC) proteins (TSC1/TSC2) in pathology have focused mainly on their capacity to regulate translation and cell growth, but their relationship with alterations of cellular structures ...
Maxwell, Christopher A., Barnekow, Angelika, Angelika Barnekow, Anja Kletke, Astrinidis, Aristotelis, Miguel A. Pujana, Mechthild Rosing, Aristotelis Astrinidis, Schmidt, Stephan, Bonifaci, Núria, Laia Gómez-Baldó, Gabriel Capellá, Capellá, Gabriel, Rosing, Mechthild, Gabaldón, Toni, Pujana, Miguel Angel, Robert Rottapel, Vidalain, Pierre-Olivier, Gómez-Baldó, Laia, William Senapedis, Rottapel, Robert, Vidal, Marc, Christopher A. Maxwell, Núria Bonifaci, Pierre-Olivier Vidalain, Kletke, Anja, Piekorz, Roland P., Stephan Schmidt, Senapedis, William, Toni Gabaldón, Marc Vidal, Roland P. Piekorz   +31 more
core   +1 more source

A posttranslational proteomic survey of a single anatomically preserved human 20‐week postconception brain

Journal of Anatomy, EarlyView.
A well‐preserved 20 post‐conception week human brain was obtained and finely dissected into 18 anatomically distinct regions, including the pia mater. Each region underwent in‐depth proteomic analysis, encompassing both total protein content and post‐translational modifications.
S. Bandiera, H. Bogetofte, P. Jensen, R. Hussain, S. A. Nischal, L. Rihova, G. J. Clowry, M. R. Larsen, Z. Molnár, B. C. Carlyle   +9 more
wiley   +1 more source

mTOR/miR-142-3p/PRAS40 signaling cascade is critical for tuberous sclerosis complex-associated renal cystogenesis

Cellular & Molecular Biology Letters
Background Patients with tuberous sclerosis complex (TSC) develop renal cysts and/or angiomyolipomas (AMLs) due to inactive mutations of either TSC1 or TSC2 and consequential mTOR hyperactivation.
Shuyun Zhao, Shuai Hao, Jiasheng Zhou, Xinran Chen, Tianhua Zhang, Zhaolai Qi, Ting Zhang, Sajid Jalal, Chuanxin Zhai, Lu Yin, Yufei Bo, Hongming Teng, Yue Wang, Dongyan Gao, Hongbing Zhang, Lin Huang   +15 more
doaj   +1 more source

Focal postnatal deletion of Tsc2 causes epilepsy

Frontiers in Molecular Neuroscience
Introduction Tuberous sclerosis complex (TSC) is a genetic disorder caused by mutations in either the TSC1 or TSC2 genes. These mutations prevent the TSC1/TSC2 protein complex from forming, resulting in
McCoy, Carlie, Dusing, Mary, Jerow, Lilian G., Winstel, Grace C., Zhan, Felix, Rogers, Jason L., Wesley, Madison, Otten, J. Brian, Danzer, Steve C., LaSarge, Candi L.   +9 more
openaire   +3 more sources