Results 91 to 100 of about 25,325 (232)
Increased expression of IGF2 transcripts in TSC2— human LAM cells and Tsc2-/- MEFs.
, 2018 (A) TSC2 levels in human TSC2-null LAM 621–102 cells (TSC2—) cells and TSC2 re-expressing 621–103 LAM (TSC2++) cells. (B) RNA-Seq results show increased IGF2 transcripts per kilobase million (TPM) in TSC2— cells.
Maya Shumyatcher (5215781) +9 more
core +1 more source
Carboxy terminal tail of polycystin-1 regulates localization of TSC2 to repress mTOR.
PLoS ONE, 2010 Autosomal dominant polycystic kidney disease (ADPKD) is a commonly inherited renal disorder caused by defects in the PKD1 or PKD2 genes. ADPKD is associated with significant morbidity, and is a major underlying cause of end-stage renal failure (ESRF ...
Ruhee Dere +3 more
doaj +1 more source
Sustainable Development, EarlyView.ABSTRACT This study examines how dynamic technological capabilities (DTCs) enable manufacturing SMEs to develop Smart and Green SCM practices and thereby improve green performance. Drawing on the dynamic capabilities view, this study conceptualizes DTCs along three dimensions: technological sensing, technological learning, and technological integration.
Xintong Liu +3 more
wiley +1 more source
STAT3-dependent upregulation of IGF2 in TSC2-null cells.
, 2018 (A) Re-expression of TSC2 (TSC2++) in TSC2-null LAM 102 (TSC2—) cells decreased STAT3 expression and activation. (B) siRNA-induced knockdown of STAT3 decreased STAT3 levels in TSC2— cells.
Maya Shumyatcher (5215781) +9 more
core +1 more source
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source
TSC2 negatively regulates AdPLA2 expression in vivo.
, 2014 Female CB17-scid mice were subcutaneously inoculated with ELT3-V3 cells (TSC2-, vector) or ELT3-T3 (TSC2+, TSC2 addback) cells (n = 8 mice/group). (A) Immunoblotting analysis of AdPLA2 and phospho-S6 (S235/236) in xenograft tumors of ELT3 cells.
Po-Shun Lee (358563) +10 more
core +1 more source
Cancer Science, EarlyView.Spatial multi‐omics mapping of hepatic angiomyolipoma reveals that PEComas tightly co‐localize with endothelial cells, which drive autophagic flux in adjacent tumor cells via a paracrine PDGFD–PDGFRB–Ras axis, establishing a compensatory survival network that operates in parallel to canonical TSC–mTOR defects.
Xinyang Liu +9 more
wiley +1 more source
Cell Death and DiseaseTuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by inactivating mutations in TSC1 or TSC2 gene, leading to mTORC1 hyperactivation. However, mTORC1-independent mechanisms in this disorder remain poorly understood.
Xiaoqiao Yue +9 more
doaj +1 more source
Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling
Cytopathology, EarlyView.Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu +3 more
wiley +1 more source
Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations.
, 2020 The TSC complex is the cognate GTPase-activating protein (GAP) for the small GTPase Rheb and a crucial regulator of the mechanistic target of rapamycin complex 1 (mTORC1).
Kiontke, Stephan +31 more
core +1 more source