Results 131 to 140 of about 36,428 (236)
TSC2 modulates cell adhesion and migration via integrin-α1β1
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2012 Recent evidence suggests that the rare and progressive lung disease lymphangioleiomyomatosis (LAM) is metastatic in nature. Dysfunction of the tumor suppressor genes tuberous sclerosis complex (TSC), in particular mutational inactivation of TSC2, enhances both cell proliferation and migration.
Lyn M, Moir +2 more
openaire +3 more sources
Molecular pathology of phyllodes tumours of the breast—much more than MED12
Histopathology, Volume 88, Issue 6, Page 1115-1125, May 2026.Phyllodes tumours can develop from fibroadenomas bearing MED12 variants by the development of pTERT alterations (“MED12 pathway”) or de novo (“MED12 independent pathway”). Grade progression is associated with increasing genetic complexity including cancer driver gene aberrations. Molecular alterations can be useful in assigning grade and distinguishing
Jia‐Min B Pang +3 more
wiley +1 more source
ChemSusChem, Volume 19, Issue 8, 28 April 2026.This prospective life cycle analysis evaluates perovskite–silicon (PSC–Si) tandem solar cells (TSCs), assessing environmental impacts from their material extraction to end‐of‐life. We compare the environmental impact of four TSC designs with that of silicon PV, highlighting hotspots in tandem architecture, and explore strategies to reduce environmental
Mercy Jelagat Kipyator +5 more
wiley +1 more source
Tuberous Sclerosis Complex: mutations, functions and phenotypes [PDF]
, 2005 Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterised by the development of hamartomas in multiple organs and tissues. TSC is caused by mutations in either the TSC1 or TSC2 gene.
Sancak, O. (Ozgur)
core +1 more source
RHEB1 Expression in Embryonic and Postnatal Mouse
, 2016 Ras homolog enriched in brain (RHEB1) is a member within the superfamily of GTP-binding proteins encoded by the RAS oncogenes. RHEB1 is located at the crossroad of several important pathways including the insulin-signaling pathways and thus plays an ...
Clement, Joachim H +8 more
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The Development of Methods of BLOTCHIP®-MS for Peptidome: Small Samples in Tuberous Sclerosis
Current Issues in Molecular BiologyMutations in TSC1 or TSC2 in axons induce tuberous sclerosis complex. Neurological manifestations mainly include epilepsy and autism spectrum disorder (ASD). ASD is the presenting symptom (25–50% of patients).
Kunio Yui +6 more
doaj +1 more source
[TSC2/PKD1 contiguous gene deletion syndrome].
Anales de pediatria (Barcelona, Spain : 2003), 2014 The TSC2 gene responsible for Tuberous Sclerosis, is located in chromosome 16p 13.3, adjacent to the gene for autosomal dominant polycystic kidney disease. A large deletion can involve both genes, causing the so-called TSC2/PKD1 contiguous gene syndrome (MIM#600273).
S, Llamas Velasco +5 more
openaire +1 more source
An Analysis of the Dismal Theorem [PDF]
In a series of papers, Martin Weitzman has proposed a Dismal Theorem. The general idea is that, under limited conditions concerning the structure of uncertainty and preferences, society has an indefinitely large expected loss from high-consequence, low ...
William D. Nordhaus
core +3 more sources
Determinants of Business Cycle Comovement: A Robust Analysis [PDF]
This paper investigates the determinants of business cycle comovement between countries. Our dataset includes over 100 countries, both developed and developing.
Marianne Baxter, Michael A. Kouparitsas
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