Results 131 to 140 of about 25,325 (232)

Genomic Evolution and Immune Contexture With Therapeutic Relevance in Pancreatic Neuroendocrine Neoplasms

Cancer Science, Volume 117, Issue 10, Page 2619-2635, October 2026.
Lineage‐dependent immunogenomic landscapes and biologically informed therapy in pancreatic neuroendocrine neoplasms. Pancreatic neuroendocrine neoplasms display lineage‐dependent immunogenomic landscapes, in which genomic alterations, epigenetic states, antigen‐presentation status, immune‐cell infiltration, and suppressive microenvironments co‐evolve ...
Yohei Tabe, Eito Nakagawa, Daisuke Asano, Eriko Katsuta, Daisuke Ban, Shogo Kumagai   +5 more
wiley   +1 more source

Chromatin remodelling by rosuvastatin normalizes TSC2-/meth cell phenotype through the expression of tuberin

, 2013
Tuberous sclerosis complex (TSC) is a multi-systemic syndrome caused by mutations in TSC1 or TSC2 gene. In TSC2-null cells, Rheb, a member of the Ras family of GTPases, is constitutively activated.
S. Ancona, E. Orpianesi, V. Grande, E. Lesma, A.M. Di Giulio, A. Gorio   +5 more
core   +1 more source

Regulation of IRS2 and TSC2 by KLF4.

, 2018
(a) Strong correlation of expression patterns of KLF4, IRS2 and TSC2 across different conditions (DC8, DW8, DC16, DW16), but little correlation with expression of the negative control gene, MTAP1B, across the different conditions.
Annamalai Muthiah (5778263), Morgan S. Angulo (5778266), Natalie N. Walker (5778269), Susanna R. Keller (745207), Jae K. Lee (31240)   +4 more
core   +1 more source

Regulation of Translation and Synaptic Plasticity by TSC2

, 2020
Mutations in TSC2 cause the disorder tuberous sclerosis (TSC), which has a high incidence of autism and intellectual disability. TSC2 regulates mRNA translation required for group 1 metabotropic glutamate receptor-dependent synaptic long-term depression (mGluR-LTD), but the identity of mRNAs responsive to mGluR-LTD signaling in the normal and TSC brain
openaire   +2 more sources

The Development of Methods of BLOTCHIP^®-MS for Peptidome: Small Samples in Tuberous Sclerosis

Current Issues in Molecular Biology
Mutations in TSC1 or TSC2 in axons induce tuberous sclerosis complex. Neurological manifestations mainly include epilepsy and autism spectrum disorder (ASD). ASD is the presenting symptom (25–50% of patients).
Kunio Yui, George Imataka, Kotaro Yuge, Hitomi Sasaki, Tadashi Shiohama, Kyoichi Asada, Hidehisa Tachiki   +6 more
doaj   +1 more source

Transient repression of TSC2 expression in the ISC lineage.

, 2012
A. TSC2 is highly expressed in GFP−, Dl+ ISCs (arrowheads) of 5966GS>GFP flies. Confocal images detecting TSC2 (red, Tritc channel, right panels) and Dl (red, Cy5 channel, left panels) were acquired using sequential scanning to separate Cy5 and TRITC ...
DaeSung Hwangbo (121326), Heinrich Jasper (121327), Benoit Biteau (121325), Subir Kapuria (121321), Jason Karpac (121323)   +4 more
core   +1 more source

TSC2 Gene [PDF]

, 2020
openaire   +1 more source

TSC2 Gene Mutation [PDF]

, 2020
openaire   +1 more source

Characterization of cellular abnormalities due to loss of TSC2

, 2014
Tuberous sclerosis complex (TSC) is a disorder characterized by multiple benign tumours in all major organs that can result in neurological manifestations including mental retardation and autism. TSC results from mutation in TSC1 or TSC2, which together
Moosa, Alym Platinum
core   +1 more source

Immunohistochemical Diagnostic Algorithm for Renal Cell Carcinoma with Fibromyomatous Stroma

Bezmiâlem Science
Busra YAPRAK BAYRAK, Mahmut AKGUL
doaj   +1 more source