Results 131 to 140 of about 23,999 (238)
Reversion of the phenotype of human TSC2-/- smooth muscle cells
, 2007 Tuberous sclerosis complex (TSC) is a inheritable genetic disorder characterized by the development of hamartomas, which are unusual tumor-like growth found in a variety of tissues and organs.
V. Grande +4 more
core
Regulation of Translation and Synaptic Plasticity by TSC2
, 2020 Mutations in TSC2 cause the disorder tuberous sclerosis (TSC), which has a high incidence of autism and intellectual disability. TSC2 regulates mRNA translation required for group 1 metabotropic glutamate receptor-dependent synaptic long-term depression (mGluR-LTD), but the identity of mRNAs responsive to mGluR-LTD signaling in the normal and TSC brain
openaire +2 more sources
Topological Species Conservation Algorithm (TSC2)
, 2016 The Java code behind the Topological Species Conservation Algorithm (TSC2) can be found in the zip archive. A readme pdf document that contains details about how the program can be set up lies within the same ...
Catalin Stoean (3609743)
core +1 more source
The Development of Methods of BLOTCHIP®-MS for Peptidome: Small Samples in Tuberous Sclerosis
Current Issues in Molecular BiologyMutations in TSC1 or TSC2 in axons induce tuberous sclerosis complex. Neurological manifestations mainly include epilepsy and autism spectrum disorder (ASD). ASD is the presenting symptom (25–50% of patients).
Kunio Yui +6 more
doaj +1 more source
Phenotype reversion of human TSC2-/- smooth muscle cells
, 2007 Tuberous sclerosis complex (TSC) is a tumor suppressor gene syndrome resulting from the loss of function of the hamartin/tuberin complex. Two genes are implicated in TSC, TSC1 and TSC2, respectively encoding hamartin and tuberin.
V. Grande +4 more
core
Development of cardiac dysfunction in cardiac-specific TSC2-deficient mice.
, 2016 (A): Western blot analysis of TSC proteins in adult cardiomyocytes isolated from 8-week-old TSC2+/+ and TSC2-/- mice. (B): Survival curve of the mice. (C): Physiological analysis of the mice at 4 months of age. BW, HW/BW, and Lung/BW indicate body weight,
Shigemiki Omiya (3214950) +11 more
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Effects of trehalose treatment on cardiac phenotypes in TSC2-/- mice.
, 2016 (A): Western blot analysis for LC3 in trehalose-treated TSC2+/+ group. Data were normalized to alpha-tubulin protein content. White and light gray bars represent control TSC2+/+ mice and trehalose-treated TSC2+/+ mice, respectively.
Shigemiki Omiya (3214950) +11 more
core +1 more source
ROSUVASTATIN ACTING AS A DEMETHYLATING AGENT AFFECTS PROLIFERATION OF TSC2-/meth ASM CELLS
, 2012 Tuberous sclerosis complex (TSC) is a multi-systemic syndrome caused by mutations in TSC1 or TSC2 gene. TSC2-/- and TSC2-/meth smooth muscle (ASM) cells do not express tuberin and bear loss of heterozigosity caused by a double hit on TSC2 or by ...
S. Ancona +5 more
core
Effect of TBC1D7 amino acid substitutions on the TSC1-TSC2-TBC1D7 complex.
, 2014 To assess the effects of the TBC1D7 variants on the TSC1-TSC2-TBC1D7 interaction, the TBC1D7 variants were coexpressed with TSC1 and TSC2 in transfected HEK 293T cells. A.
Marianne Hoogeveen-Westerveld (549062) +7 more
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