Results 41 to 50 of about 79,060 (245)
Multimorbidity and Associations with Cognition and Alzheimer's Disease Biomarkers
Annals of Neurology, EarlyView.Objective Multimorbidity, the coexistence of 2 or more chronic conditions, has been linked to cognitive aging and Alzheimer's disease (AD) and AD‐related dementias, yet the mechanisms remain unclear. We aimed to examine the associations of multimorbidity with cognition and biomarkers across multiple mechanistic pathways.
Xiaqing Jiang +45 more
wiley +1 more source
Evaluation of thyroid hormones in type 1 diabetes mellitus
Zanco Journal of Medical SciencesBackground and objective: Increased blood sugar levels (hyperglycemia) and lack of insulin are a hallmark of Type 1 diabetes mellitus (T1DM), which is a chronic autoimmune illness results from the destruction of pancreatic beta –cells.
Amna Abdullah, Sardar N. Ahmed
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad +4 more
wiley +1 more source
Deep Underground Science and Engineering, EarlyView.Through shear–tensile creep tests and viscoelastic modeling, the fracture evolution of thick soft protective layers is clarified. Results show thickness‐dependent rheological failure modes that govern four types of roof water inrush, providing a mechanism‐based framework for hazard prediction and control. Abstract In the Jurassic coal‐bearing strata of
Mengnan Liu +4 more
wiley +1 more source
Folding-Dependent Binding of Thyrotropin (TSH) and TSH Receptor Autoantibodies to the Murine TSH Receptor Ectodomain* [PDF]
Endocrinology, 1997 The mouse TSH receptor ectodomain (mTSHR-ecd) was amplified from murine thyroid complementary DNA and ligated into the pAcGP67B insect cell vector, and the nucleotide sequence was confirmed. Employing a baculovirus-insect cell system, the mTSHR-ecd (amino acids 22-415) was expressed as a fusion protein with the gp67 insect cell signal sequence at the ...
H, Vlase +4 more
openaire +2 more sources
Journal of Family Medicine and Primary CareBackground: The thyroid gland is one of the largest endocrine glands in the body, secreting thyroxine (T4) and triiodothyronine (T3). Mild hypothyroidism can have negative consequences for a variety of tissues, even though clinically the patients are ...
Bhagyashree Gali, Vanishree S. Bubanale
doaj +1 more source
Клиническая и экспериментальная тиреоидология, 2010 In our study we try to determine whether small changes in thyroxine treatment is effective in patients with symptoms of hypothyroidism but with thyroid function tests within the reference range, and to investigate the effect of thyroxine treatment on ...
doaj +1 more source
TSH promotes adiposity by inhibiting the browning of white fat
Adipocyte, 2020 Adiposity is caused by an imbalance between energy intake and consumption. Promotion of the browning of white fat increases energy expenditure and could combat adiposity.
Jianmei Zhang +6 more
doaj +1 more source
The Change of Thyroid Stimulating Hormone Values of Healthy Subjects According toTemperature and Aging [PDF]
Kosin Medical Journal, 2014 Objective: We conducted a study to investigate the normal range for TSH and within-individual variations of TSH according to temperat䴸re and aging. Patients and Methods: We enrolled patients who underwent periodic medical examinations five times over a ...
Sung Su Kim +9 more
doaj +1 more source
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Anorexia nervosa (AN) is a serious illness in which more than half of all deaths are due to malnutrition. Critically low energy and protein intake are known causes of massive weight loss, whereas micronutrient deficiencies due to a low‐calorie food pattern remain poorly characterized in children with AN. Micronutrient deficiencies in
Zenaida Iordan +6 more
wiley +1 more source