Results 41 to 50 of about 153,227 (272)

HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation

eLife, 2023
Tristetraprolin (TTP) is a critical negative immune regulator. It binds AU-rich elements in the untranslated-regions of many mRNAs encoding pro-inflammatory mediators, thereby accelerating their decay.
Sara Scinicariello, Adrian Soderholm, Markus Schäfer, Alexandra Shulkina, Irene Schwartz, Kathrin Hacker, Rebeca Gogova, Robert Kalis, Kimon Froussios, Valentina Budroni, Annika Bestehorn, Tim Clausen, Pavel Kovarik, Johannes Zuber, Gijs A Versteeg   +14 more
doaj   +1 more source

Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression

Advanced Science, EarlyView.
This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang, Shucheng Jin, Penghui Guo, Yuying Yin, Yichun Hua, Xiaosheng Ding, Zhe Zhang, Shuo Chen, Xu Han, Baowang Li, Yan Liu, Xiaoyan Li, Deling Li, Jing Jing, Wei Shi, Wang Jia   +15 more
wiley   +1 more source

Bottom-quark effects in Higgs production at intermediate transverse momentum

Journal of High Energy Physics, 2018
We provide a precise description of the Higgs boson transverse momentum distribution including top and bottom quark contributions, that is valid for transverse momenta in the range m b  ≲ p ⊥ ≲ m t , where m b and m t are the bottom and top quark masses.
Fabrizio Caola, Jonas M. Lindert, Kirill Melnikov, Pier Francesco Monni, Lorenzo Tancredi, Christopher Wever   +5 more
doaj   +1 more source

Multi-Orbital Molecular Compound (TTM-TTP)I_3: Effective Model and Fragment Decomposition

, 2010
The electronic structure of the molecular compound (TTM-TTP)I_3, which exhibits a peculiar intra-molecular charge ordering, has been studied using multi-configuration ab initio calculations.
Bonnet M.-L., Cano-Cortés L., Fujimura N., Ishibashi S., Karlström G., Maesato M., Mori T., Mori T., Mori T., Mori T., Mori T., Nakamura K., Nogami Y., Onuki M., Perdew J. P., Rovira C., Scriven E., Seo H., Seo H., Tanaka H., Tsuchiizu M., Yakushi K., Yasuzuka S.   +22 more
core   +1 more source

Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay. [PDF]

, 2015
Skeletal muscle satellite cells in their niche are quiescent and upon muscle injury, exit quiescence, proliferate to repair muscle tissue, and self-renew to replenish the satellite cell population.
Blackshear, Perry J, Cadwallader, Adam B, Clement, Sandra L, Doles, Jason D, Hall, Monica N, Hausburg, Melissa A, Lykke-Andersen, Jens, Olwin, Bradley B   +7 more
core   +2 more sources

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Advanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang   +29 more
wiley   +1 more source

TIM: threat context-enhanced TTP intelligence mining on unstructured threat data

Cybersecurity, 2022
TTPs (Tactics, Techniques, and Procedures), which represent an attacker’s goals and methods, are the long period and essential feature of the attacker.
Yizhe You, Jun Jiang, Zhengwei Jiang, Peian Yang, Baoxu Liu, Huamin Feng, Xuren Wang, Ning Li   +7 more
doaj   +1 more source

Fermiology and superconductivity studies on the non-tetrachalcogenafulvalene structured organic superconductor beta-(BDA-TTP)_2SbF_6

, 2002
The quantum oscillatory effect and superconductivity in a non-tetrachalcogenafulvalene (TCF) structure based organic superconductor beta-(BDA-TTP)_2SbF_6 are studied.
A. A. House, A. Wade, B. Andraka, C. H. Mielke, D. -H. Wu, E. Goetz, E. Jobilong, E. S. Choi, E. S. Choi, F. Zuo, F. Zuo, G. J. Athas, H. Elsinger, H. Weiss, I. M. Lifshitz, J. Caulfield, J. M. Luttinger, J. Merino, J. Müller, J. S. Brooks, J. Wosnitza, J. Wosnitza, J. Wosnitza, J. Wosnitza, J. Yamada, J. Yamada, K. Yamaji, M. Tokumoto, M. V. Kartsovnik, M. V. Kartsovnik, N. Hanasaki, P. Moses, R. C. Moris, S. Kamiya, S. Sridhar, S. Wanka, S. Wanka, T. Kawamoto, T. Kinoshita, T. Mizutani, T. Schneider, V. G. Peschansky, W. Kang, Y. Shimojo   +43 more
core   +1 more source

The Gut Commensal Butyricimonas Virosa Modulates Gut Microbiota‐Dependent Thiamine Metabolism and Attenuates Mouse Steatotic Liver Disease

Advanced Science, EarlyView.
This study reveals that dietary stachyose enriches Butyricimonas virosa, effectively attenuating metabolic dysfunction‐associated steatotic liver disease (MASLD). Mechanistically, B. virosa enhances gut thiamine monophosphate synthesis, which elevates hepatic thiamine pyrophosphate levels.
Ningning He, Haoyu Wang, Zizhen Yang, Hui Li, Bei Liu, Kaiwei Chen, Zhinan Wu, Xinnan Zhao, Hewei Liang, Mengmeng Wang, Xiaofang Li, Yiyi Zhong, Haifeng Zhang, Liang Xiao, Karsten Kristiansen, Jixing Peng, Yuanqiang Zou, Shangyong Li   +17 more
wiley   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source