Results 71 to 80 of about 59,427 (290)

Use of PopPK and E‐R Analyses toward Explaining Causal Link Between ADAMTS13 in Recombinant vs. Plasma‐Based Therapies and Clinical Effects in cTTP

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Congenital thrombotic thrombocytopenic purpura (cTTP) is an ultra‐rare, potentially life‐threatening condition caused by a deficiency of the blood enzyme ADAMTS13. Until now, ADAMTS13 replacement has been achieved with infusions of plasma or plasma‐based therapies (PBT).
Munjal Patel   +11 more
wiley   +1 more source

TTP-HUS Associated with Sunitinib [PDF]

open access: yesCancer Research and Treatment, 2008
Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS) is a rare condition that is severe and may be fatal. Adverse reactions to drugs increasingly are reported as probable causes of TTP-HUS. Many chemotherapeutic agents have also been implicated in causing TTP-HUS. We reported a woman with metastatic renal cell carcinoma who presented
Moon Ki Choi   +3 more
openaire   +2 more sources

Cu(I) Disrupts the Structure and Function of the Nonclassical Zinc Finger Protein Tristetraprolin (TTP).

open access: yesInorganic Chemistry, 2017
Tristetraprolin (TTP) is a nonclassical zinc finger (ZF) protein that plays a key role in regulating inflammatory response. TTP regulates cytokines at the mRNA level by binding to AU-rich sequences present at the 3'-untranslated region, forming a complex
Geoffrey D. Shimberg   +4 more
semanticscholar   +1 more source

Detection of focal impaired awareness seizures using a biometric shirt

open access: yesEpilepsia Open, EarlyView.
Abstract Objective In recent years, seizure detection using wearable technology has gained significant attention in research. Most studies, however, have focused on detecting generalized or focal to bilateral tonic–clonic seizures. This study evaluates the feasibility of using a biometric shirt to detect focal impaired awareness seizures (FIAS) by ...
Jérôme St‐Jean   +6 more
wiley   +1 more source

CREB targets define the gene expression signature of malignancies having reduced levels of the tumor suppressor tristetraprolin. [PDF]

open access: yesPLoS ONE, 2014
The RNA-binding protein Tristetraprolin (TTP, ZFP36) functions as a tumor suppressor that impairs the development and disables the maintenance of MYC-driven lymphoma.
Mohammad Fallahi   +3 more
doaj   +1 more source

Structural design and property regulation of organic polymers for photocatalytic synthesis of H2O2

open access: yesInfoScience, EarlyView.
Photocatalytic synthesis of H2O2 offers a sustainable approach. Photocatalytic efficiency depends critically on interfacial electron transfer kinetics and spatial charge separation. Herein, we systematically analyze key factors governing photogenerated carrier dynamics and propose engineered strategies to optimize performance, thereby providing design ...
Mingyang Xu   +8 more
wiley   +1 more source

The functional characterization of phosphorylation of tristetraprolin at C-terminal NOT1-binding domain

open access: yesJournal of Inflammation, 2021
Background Tristetraprolin (TTP) family proteins contain conserved tandem CCCH zinc-finger binding to AU-rich elements and C-terminal NOT1-binding domain.
Hsin-Hui Hsieh   +8 more
doaj   +1 more source

Adjuvant rituximab to prevent TTP relapse.

open access: yesBlood, 2016
In this issue of Blood, Page et al show that treatment with rituximab at the time of an initial episode of thrombotic thrombocytopenic purpura (TTP) is associated with a dramatic reduction in the risk of subsequent relapse.
A. Cuker
semanticscholar   +1 more source

Magnetic Resonance Imaging in the Clinical Evaluation of Lung Disorders: Current Status and Future Prospects

open access: yesJournal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT The low proton density and high signal decay rate of pulmonary tissue have previously hampered the application of magnetic resonance imaging (MRI) in the clinical evaluation of lung disorders. With the continuing technical advances in scanners, coils, pulse sequences, and image postprocessing, pulmonary MRI can provide structural and ...
Linyu Wu   +7 more
wiley   +1 more source

Higgs bosons with large transverse momentum at the LHC

open access: yesPhysics Letters B, 2018
We compute the next-to-leading order QCD corrections to the production of Higgs bosons with large transverse momentum p⊥≫2mt at the LHC. To accomplish this, we combine the two-loop amplitudes for processes gg→Hg, qg→Hq and qq¯→Hg, recently computed in ...
Kirill Kudashkin   +3 more
doaj  

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