Results 91 to 100 of about 29,634 (242)

Memantine prevents acute stress‐induced memory deficits by reversing sex‐dependent pathophysiological glutamatergic alterations in the dorsal hippocampus

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The neural mechanisms underlying effects of acute stress on memory are poorly understood. We demonstrated previously that acute stress produces identical spatial memory deficits in male and female mice but through distinct molecular mechanisms, with females exhibiting up‐regulation of N‐methyl‐D‐aspartate (NMDA) receptor
Sebastiano A. Torrisi, Lidia Diolosà, Giuseppe Aceto, Claudia Marchetti, Federica Geraci, Konstantinos Partsinevelos, Silvia Rizzo, Margherita Grasso, Filippo Caraci, Francesco Bellia, Giovanni Li Volti, Angela Maria Amorini, Marcello D′Ascenzo, Gian Marco Leggio   +13 more
wiley   +1 more source

Neuroplastic alteration of TTX-resistant sodium channel with visceral pain and morphine-induced hyperalgesia

, 2012
Jinghong Chen,1,2,4 Ze-hui Gong,4 Hao Yan,2 Zhijun Qiao,3 Bo-yi Qin41Department of Internal Medicine, Neuroscience Program, The University of Texas Medical Branch, Galveston, TX, USA; 2The Divisions of Pharmacy, Pharmacology core lab, MD Anderson Cancer ...
Chen J, Gong Z, Yan H, Qiao Z, Qin B
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Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, EarlyView.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

UMPSA anjur Kursus Emergency Tabletop Exercise (TTX) 2025 [PDF]

PEKAN, 22 Julai 2025 – Seramai 36 orang staf daripada Pusat Bahasa Moden (PBM) dan Pusat Tanggungjawab (PTJ) lain di Zon PBM, Universiti Malaysia Pahang Al-Sultan Abdullah (UMPSA) telah menyertai Kursus Emergency Tabletop Exercise (TTX) 2025 anjuran Unit
Arulselvi, Uthayakumaran, Jamilah Bebe, Mohamad   +1 more
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Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

Clinical and Psychosocial Predisposing Factors Associated With Anaesthesia Failure During Non‐Surgical Root Canal Treatment: A National Dental Practice‐Based Research Network Study

International Endodontic Journal, EarlyView.
ABSTRACT Aim This study aimed to identify dentist, patient, and pre‐treatment clinical characteristics associated with local anaesthesia failure during non‐surgical endodontic treatment. Methodology Data were collected from the National Dental Practice‐Based Research Network study entitled “Predicting Outcomes of Root Canal Treatment (PREDICT)”, which ...
Linda J. Liu, Ronald Ordinola‐Zapata, W. Craig Noblett, Ellen Funkhouser, Alan S. Law, Donald R. Nixdorf, Ernest W. N. Lam, Rahma Mungia, Gregg H. Gilbert, The National Dental Practice‐Based Research Network Collaborative Group   +9 more
wiley   +1 more source

'G.A.T.E': Gap analysis for TTX evaluation

, 2016
A Table Top Exercise (TTX) gap analysis tool was developed with the aim to provide a complete, systematic and objective evaluation of TTXs organized in safety and security fields.
CACCIOTTI, ILARIA, PALOMBI, LEONARDO, Cacciotti, I, CARESTIA, MARIACHIARA, Gaudio, P, Alessandro Pergolini, Leonardo Palombi, MALIZIA, ANDREA, Di Giovanni, D, Carlo Bellecci, DI GIOVANNI, DANIELE, BELLECCI, CARLO, Palombi, L, Daniele Di Giovanni, GAUDIO, PASQUALINO, Andrea Malizia, Pasquale Gaudio, Malizia, A, Pergolini, A, Ilaria Cacciotti, Carestia, M, Bellecci, C, Mariachiara Carestia   +22 more
core   +1 more source

Integration of cortical inputs in the lateral hypothalamus is dominated by the medial prefrontal cortex

The Journal of Physiology, EarlyView.
Abstract figure legend The lateral hypothalamus (LH) is a critical controller of innate behaviours such as feeding. It is anatomically connected to specific cortical areas. We mapped these areas using a combination of retrograde tracing and anterograde optogenetic circuit mapping.
Lotte J. A. M. Razenberg, Pieter Nicolaas de Greef, Huibert D. Mansvelder, Mahesh Miikael Karnani   +3 more
wiley   +1 more source

Functional Constraints and the Evolution of TTX-resistance in TTX-bearing Salamanders

, 2013
Tetrodotoxin (TTX) binds to voltage-gated sodium (NaV) channels, blocking the initiation of action potentials and the activity of nerve and muscle fibers. Some salamanders use TTX as an anti-predator defense.
Haslem, Angela
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