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Inactivation of TTX-sensitive and TTX-insensitive sodium channels of rat myoballs
Neuroscience Letters, 1987Myoballs, spherical muscle cell regenerates, have two types of Na+ channels, the adult type with a high sensitivity to the Na+ channel blocker tetrodotoxin (TTX), and the juvenile type with 10 times less TTX sensitivity. The potential dependence of the steady-state inactivation of the Na+ channels (h infinity-curve) was studied in 50 rat myoballs with ...
J P, Ruppersberg, A, Schure, R, Rüdel
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A Mutant of TTX-Resistant Cardiac Sodium Channels with TTX-Sensitive Properties
Science, 1992The cardiac sodium channel α subunit (RHI) is less sensitive to tetrodotoxin (TTX) and saxitoxin (STX) and more sensitive to cadmium than brain and skeletal muscle (μl) isoforms. An RHI mutant, with Tyr substituted for Cys at position 374 (as in μl) confers three properties of TTX-sensitive channels: (i) greater sensitivity to TTX (730-fold); (ii ...
J, Satin +6 more
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Effects of ATP on TTX-sensitive and TTX-resistant sodium currents in rat sensory neurons
Neuroreport, 2001Differential effects of ATP on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium currents in rat dorsal root ganglion neurons were studied using the whole-cell variation of path-clamp technique. Currents were evoked by step depolarizations to 0 mV from a holding potential of -80 mV.
J H, Song +4 more
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‘G.A.T.E’: Gap analysis for TTX evaluation
AIP Conference Proceedings, 2016A Table Top Exercise (TTX) gap analysis tool was developed with the aim to provide a complete, systematic and objective evaluation of TTXs organized in safety and security fields. A TTX consists in a discussion-based emergency management exercise, organized in a simulated emergency scenario, involving groups of players who are subjected to a set of ...
CACCIOTTI, ILARIA +7 more
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