Results 41 to 50 of about 37,801 (251)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie   +8 more
wiley   +1 more source

Stage-Specific Light Intensity Optimization for Yield and Energy Efficiency in Plant Factory Potato Pre-Basic Seed Production

open access: yesAgronomy
This study investigated the effects of light intensity regulation on yield and energy efficiency during potato pre-basic seed propagation in plant factories.
Song Chen, Jiating Lin, Zhigang Xu
doaj   +1 more source

Potato Tuber Shape Phenotyping Using RGB Imaging

open access: yesAgronomy, 2021
Potato tuber shape is an important quality trait for breeding and variety development. Length to width (L/W) ratio is a commonly used method to score potato tubers for suitability for different markets and is relatively easy to measure, though labor ...
Jonathan A. D. Neilson   +5 more
doaj   +1 more source

Elastomeric 3D‐Printed Microenvironments Enable Nanonewton Force Measurements in Healthy and Diseased Human Pluripotent Stem Cell‐Derived Neuroepithelial Cells

open access: yesAdvanced Materials, EarlyView.
We present elastomeric three‐dimensional (3D) microstructures fabricated via two‐photon polymerization (2PP) and post‐processed through wet etching, for quantifying nanonewton (nN)‐scale forces applied by healthy and diseased neural cells. The mechanically characterized free‐standing beam architectures enable measurement of traction forces of ...
Pieter F. J. van Altena   +7 more
wiley   +1 more source

Auto‐Downregulation of the Florigen FT Production Prevents Precocious Flowering in Plants

open access: yesAdvanced Science, EarlyView.
This study shows that the leaf vein‐expressed FD complexes with the florigen FT to bind DNA motifs in FT promoter, which antagonizes CONSTANS‐mediated FT activation to feedback down‐regulate FT expression. This prevents an excessive induction of FT expression by inductive photoperiods, thereby precluding precocious transition to flowering in ...
Shu Tian, Xiao Luo, Bowen Cui, Yuehui He
wiley   +1 more source

Impact of different planting date on shoot growth and tuber development of white Guinea yam grown in Guinea Savanna

open access: yesPlant Production Science
White Guinea yam is a tuber crop characterized by a long growth period over the entire rainy season, which is affected by changes in rainfall patterns owing to climate change.
Kohtaro Iseki   +2 more
doaj   +1 more source

Traceability of Agri‐Food Products: The Key to Conscious Trade

open access: yesAgribusiness, EarlyView.
ABSTRACT Globalization and growing concerns about sustainability have led to improvements in product traceability, quality, and sustainability. Traceability contributes to environmental protection and supports sustainable development by fostering transparency in agricultural practices and encouraging the responsible use of resources.
Scarlett Queen Almeida Bispo   +5 more
wiley   +1 more source

Using non-woven polypropylene covers in potato production: a review [PDF]

open access: yesJournal of Central European Agriculture, 2016
This paper analyzes the effect of non-woven polypropylene covers on plant growth and development, frost protection, tuber yield and quality and the economic effectiveness in early potato production.
Wanda Wadas
doaj   +1 more source

Advancing European Plant Variety Registration: Data‐Driven Insights and Stakeholder Perspectives

open access: yesAgribusiness, EarlyView.
ABSTRACT Efficient plant variety registration is crucial for fostering innovation in the European Union, yet the current regulatory framework is complex and faces calls for reform. This study provides data‐driven evidence to inform the ongoing legislative debate by employing a mixed‐methods approach.
Sergio Urioste Daza   +2 more
wiley   +1 more source

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