Results 91 to 100 of about 828,953 (227)

Binding of Bacillus subtilis dynamin‐like protein DynA to the bacterial membrane is essential for effective phage defense

The FEBS Journal, EarlyView.
The bacterial dynamin‐like protein DynA from Bacillus subtilis plays a key role in phage defense. It binds the plasma membrane through a unique paddle domain in its D1 subunit. This membrane association is essential for its protective function, likely preventing explosive membrane rupture following phage infection.
Samia Shafqat, Urska Repnik, Marc Bramkamp   +2 more
wiley   +1 more source

Conditional deletion of the multiple sclerosis susceptibility gene ATXN1 identifies cell‐autonomous effects in the B‐cell compartment

The FEBS Journal, EarlyView.
Ataxin‐1 is a polyglutamine protein associated with the etiology of spinocerebellar ataxia type 1 (SCA1) that has been recently found implicated in the risk of developing the autoimmune disorder multiple sclerosis (MS). Here, we took a conditional knockout approach to ablate ataxin‐1 exclusively in the B‐cell compartment and we found that this protein ...
Jonathan Jacob Carver, Rachael Riley Denbrock, Cindy Carolina Martines, Alessandro Didonna   +3 more
wiley   +1 more source

Spillover of Mycobacterium bovis from Wildlife to Livestock, South 
Africa

Emerging Infectious Diseases, 2015
During August 2012–February 2013, bovine tuberculosis was detected in communal livestock bordering the Greater Kruger National Park Complex (GKNPC) in South Africa.
Jolly Musoke, Tiny Hlokwe, Tanguy Marcotty, Ben J.A. du Plessis, Anita L. Michel   +4 more
doaj   +1 more source

Incidence of bovine tuberculosis in cattle in seven Central European countries during the years 1990-1999

, 2018
The post-eradication incidence of bovine tuberculosis in seven Central European Countries (Bosnia and Herzegovina, Croatia, Czech Republic, Hungary, Poland, Slovakia and Slovenia) was studied between 1990 and 1999. The majority of cattle to the age of 24
I. Pavlik, W. Y. Ayele, I. Parmova, I. Melicharek, M. Hanzlíková, B. Körmendy, G. Nagy, Ž. Cvetnić, M. Ocepek, N. Fejzić, M. Lipiec, Veterinary Faculty   +11 more
semanticscholar   +1 more source

Molecular characterization of bovine tuberculosis strains in two slaughterhouses in Morocco

BMC Veterinary Research, 2017
BackgroundBovine tuberculosis (BTB) is caused by Mycobacterium bovis, which belongs to the Mycobacterium tuberculosis complex. Mycobacterium bovis have been described to be responsible of most cases of bovine tuberculosis. Although M.
Hind Yahyaoui-Azami, H. Aboukhassib, M. Bouslikhane, J. Berrada, Soukaina Rami, Miriam Reinhard, S. Gagneux, J. Feldmann, S. Borrell, J. Zinsstag   +9 more
semanticscholar   +1 more source

The Dual Immunoregulatory Role of CREB3L1 Underlying Latent and Severe Tuberculosis Clinical Manifestation

Immunology, EarlyView.
RNA‐seq of lungs and livers from Mycobacterium tuberculosis‐infected mice with distinct disease outcomes revealed organ‐specific responses driven by differences in immune activity and bacterial burden. Meta‐analysis identified orthologous genes shared with human latent TB and mouse liver, with Creb3l1, Myo7b, Cyyr1 and Cbs differentially expressed and ...
Felipe T. Lima, Ricardo C. Castro, Francisco R. Javier, Caroline Fontanari, Valdes R. Bollela, Rogerio S. Rosada, Célio L. Silva, Lúcia H. Faccioli, Luiz G. Gardinassi, Fabiani G. Frantz   +9 more
wiley   +1 more source

Bovine Tuberculosis and Badger Culling in England: A Utilitarian Analysis of Policy Options

, 2017
Bovine tuberculosis (bovine TB) is an important animal health policy issue in Britain, which impacts farmers, the public, domestic farmed cattle and the wild badger population. The Westminster government’s badger culling policy in England, which began in
S. McCulloch, M. Reiss
semanticscholar   +1 more source

Signal Transducer and Activator of Transcription (STAT) Proteins Regulate Mucosal‐Associated Invariant T (MAIT) Cell Function

Immunology, EarlyView.
Integrated transcriptomic, proteomic and flow cytometry analyses reveal that STAT1 negatively regulates MAIT cell effector and glycolytic functions, while STAT3, STAT5 and HIF1α act as positive modulators. Targeting these pathways may offer new strategies to restore MAIT cell function in immune dysregulation and cancer.
Olivia J. Cheng, Eimear K. Ryan, Michael Bennett, Christy Clutter, Jackson G. Cacioppo, Jeffrey Aubé, Andy E. Hogan, Daniel T. Leung   +7 more
wiley   +1 more source

Genomic Analysis of Taurine and Indicine Ancestry in the Montana Tropical Composite Population

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT The Montana Tropical cattle, a Taurine and Indicine composite, were developed in Brazil since 1994 and were based on crossing four biological types of cattle: zebu (mainly Nelore), tropical adapted taurine (mainly Senepol and Romosinuano), British taurine (mainly Angus) and continental taurine (as Charolais, Simental and Limousin).
Camila Alves dos Santos, El Hamidi Hay, Elisangela Chicaroni de Mattos Oliveira, Rafael Espigolan, José Bento Sterman Ferraz, Tiago do Prado Paim   +5 more
wiley   +1 more source

Bovine Tuberculosis Policy in England: Would a Virtuous Government Cull Mr Badger?

, 2017
Bovine tuberculosis (bovine TB) is the most important animal health and welfare policy issue in Britain. Badgers are a wildlife reservoir of disease, although the eight-year Independent Scientific Group (ISG) Randomised Badger Culling Trial concluded ...
S. McCulloch, M. Reiss
semanticscholar   +1 more source