Results 51 to 60 of about 127,769 (266)

Cinnamic Acid Derivatives in Tuberculosis, Malaria and Cardiovascular Diseases - A Review [PDF]

Current Organic Chemistry, 2012
Cinnamic acid and its phenolic analogues are natural substances. Chemically, cinnamic acids or the 3-phenyl acrylic acids, offer three main reactive sites: substitution on the phenyl ring, addition on the α ,β -unsaturation and reactions of the carboxylic acid.
De, Prithwiraj, Bedos-Belval, Florence, Vanucci-Bacqué, Corinne, Baltas, Michel   +3 more
openaire   +2 more sources

Cardiovascular Involvement in Tuberculosis: From Pathophysiology to Diagnosis and Complications—A Narrative Review

Diagnostics, 2023
Although primarily a lung disease, extra-pulmonary tuberculosis (TB) can affect any organ or system. Of these, cardiovascular complications associated with disease or drug toxicity significantly worsen the prognosis. Approximately 60% of patients with TB have a cardiovascular disease, the most common associated pathological entities being pericarditis,
Dragos Traian Marius Marcu, Cristina Andreea Adam, Florin Mitu, Carmen Cumpat, Viviana Aursulesei Onofrei, Mihai Lucian Zabara, Alexandru Burlacu, Radu Crisan Dabija   +7 more
openaire   +3 more sources

Non-traumatic chest pain in patients presenting to an urban emergency Department in sub Saharan Africa: a prospective cohort study in Tanzania. [PDF]

, 2019
BACKGROUND:Non-traumatic chest pain (NTCP) is a common reason for emergency department (ED) attendance in high-income countries, with the primary concern focused on life threatening cardiovascular diseases.
Marombwa, Nafsa R, Mjema, Kilalo, Mohamed, Amour S, Muhanuzi, Biita, Sawe, Hendry R, Weber, Ellen J   +5 more
core  

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

Transformations to achieve the Sustainable Development Goals Includes the SDG Index and Dashboards. Sustainable Development Report 2019 [PDF]

, 2019
The Sustainable Development Report 2019 presents an updated SDG Index and Dashboards with a refined assessment of countries’ distance to SDG targets. The report has been successfully audited for the first time by the European Commission Joint Research ...
Fuller, G., Kroll, C., Lafortune, G., Sachs, J., Schmidt-Traub, G.   +4 more
core  

Tuberculosis incidence correlates with sunshine : an ecological 28-year time series study [PDF]

, 2013
Birmingham is the largest UK city after London, and central Birmingham has an annual tuberculosis incidence of 80 per 100,000. We examined seasonality and sunlight as drivers of tuberculosis incidence. Hours of sunshine are seasonal, sunshine exposure is
Alice M. Turner, AR Martineau, AR Martineau, AR Webb, AS Douglas, AS Douglas, CM Parrinello, D Ganmaa, E Vynnycky, ERN Grigg, Gavin C. K. W. Koh, Gemma Hawthorne, H Korthals Altes, Heinke Kunst, J Bennett, KE Nnoaham, KP Burnham, M Fabri, Madhukar Pai, Martin Dedicoat, MF Holick, PT Liu, SD Lawn, T-T Wang   +23 more
core   +4 more sources

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

The Causes and Risk Factors of Tuberculosis Deaths in Khuzestan [PDF]

Acta Medica Iranica, 2009
Tuberculosis (TB) is one of the 10 leading cause of deaths in developing countries. Understanding the cause and risk factors of TB death and lowering them can reduce its mortality rate.
Alavi Seyed Mohammad, Salami Nejad
doaj   +2 more sources

Inclusion of patient-centered, non-microbiological endpoints and biomarkers in tuberculosis drug trials

Frontiers in Antibiotics
Tuberculosis drug trials are primarily designed to identify antibiotic regimens with the strongest potency to kill Mycobacterium tuberculosis. However, microbiologic cure is not synonymous with improved health and recovery. Beyond antimicrobial efficacy,
Andrew R. DiNardo, Andrew R. DiNardo, Wilbert Sabiiti, Stephen H. Gillespie, Sophia B. Georghiou, Norbert Heinrich, Norbert Heinrich, Norbert Hittel, Sami Taghlabi, Danna Carrero Longlax, Mikashmi Kohli, Ursula Panzner, Ursula Panzner, Collins Musia, Christoph Lange, Christoph Lange, Christoph Lange, Christoph Lange, Anca Vasiliu, Anca Vasiliu, Anca Vasiliu, Rob J. W. Arts, Anna M. Mandalakas, Anna M. Mandalakas, Anna M. Mandalakas, Morten Ruhwald, Lieven J. Stuyver, Reinout van Crevel, Reinout van Crevel   +28 more
doaj   +1 more source

Ethnomedicinal Plants from Iraq as Therapeutic Agents against Mycobacterium tuberculosis: A Review

Journal of Pure and Applied Microbiology, 2019
Mycobacterium tuberculosis is a highly infectious pathogen, which can affect both humans and animals. The metabolic products of this bacterium affect the pulmonary, nervous, lymphatic, and cardiovascular systems.
Ali Sami Dheyab, Ekremah Kheun Shaker, Abdul jabbar Khaleel Ibrahim   +2 more
doaj   +1 more source