Results 51 to 60 of about 62,602 (248)

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

The Causes and Risk Factors of Tuberculosis Deaths in Khuzestan [PDF]

Acta Medica Iranica, 2009
Tuberculosis (TB) is one of the 10 leading cause of deaths in developing countries. Understanding the cause and risk factors of TB death and lowering them can reduce its mortality rate.
Seyed Mohammad Alavi, Nejad Salami
doaj   +1 more source

Ethnomedicinal Plants from Iraq as Therapeutic Agents against Mycobacterium tuberculosis: A Review

Journal of Pure and Applied Microbiology, 2019
Mycobacterium tuberculosis is a highly infectious pathogen, which can affect both humans and animals. The metabolic products of this bacterium affect the pulmonary, nervous, lymphatic, and cardiovascular systems.
Ali Sami Dheyab, Ekremah Kheun Shaker, Abdul jabbar Khaleel Ibrahim   +2 more
doaj   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Europe's contribution to the evaluation of the use of systemic antimicrobials in the treatment of periodontitis

Periodontology 2000, EarlyView., 2023
Abstract This narrative review celebrates Europe's contribution to the current knowledge on systemically administered antimicrobials in periodontal treatment. Periodontitis is the most frequent chronic noncommunicable human disease. It is caused by dysbiotic bacterial biofilms and is commonly treated with subgingival instrumentation.
David Herrera, Arie Jan van Winkelhoff, Paula Matesanz, Katalina Lauwens, Wim Teughels   +4 more
wiley   +1 more source

Misdiagnosis of Bland-White-Garland Syndrome: Report of Two Cases with Different Presentations [PDF]

Journal of Cardiovascular and Thoracic Research, 2014
Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) or Bland-White-Garland syndrome is usually an isolated cardiac anomaly but, in rare incidences, has been described with patent ductus arteriosus, ventricular septal defect ...
Akbar Molaei, Bahman Rastkar Hemmati, Hashem Khosroshahi, Madjid Malaki, Roya Zakeri   +4 more
doaj   +1 more source

Tuberculosis of the Heart: A Diagnostic Challenge

Tomography, 2022
Tuberculosis of the heart is relatively rare and presents a significant diagnostic difficulty for physicians. It is the leading cause of death from infectious illness.
Karuna M. Das, Taleb Al Mansoori, Yousef Habeeb Alattar, Klaus V. Gorkom, Ali Shamisi, Anisha Pulinchani Melethil, Jamal Aldeen Alkoteesh   +6 more
doaj   +1 more source

Defining Features of Gabriele‐de Vries Syndrome in Adults: A Case Report and Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Gabriele‐de Vries syndrome (GADEVS) is a neurodevelopmental disorder caused by heterozygous pathogenic variants in the YY1 gene. Like most rare genetic syndromes, the adult manifestations of GADEVS remain poorly defined. Here, we describe the oldest patient reported to date with GADEVS—a 63‐year‐old woman with a c.1177_1179del YY1 variant ...
Ethan W. Hollingsworth, Changrui Xiao
wiley   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Aortic endograft infection by Mycobacterium abscessus subsp. massiliense with acquired clarithromycin resistance: a case report

BMC Infectious Diseases, 2023
Background Mycobacterium abscessus subsp. massiliense (MMA) comprises a group of non-tuberculous, rapidly growing mycobacteria. Although MMA can cause pulmonary diseases, surgical site infections, and disseminated diseases, aortic endograft infection has
Yutaro Akiyama, Noriko Iwamoto, Keisuke Kamada, Atsushi Yoshida, Asami Osugi, Satoshi Mitarai, Tetsuya Suzuki, Kei Yamamoto, Maki Nagashima, Tetsuya Horai, Norio Ohmagari   +10 more
doaj   +1 more source