Induced CNS expression of CXCL1 augments neurologic disease in a murine model of multiple sclerosis via enhanced neutrophil recruitment. [PDF]
Increasing evidence points to an important role for neutrophils in participating in the pathogenesis of the human demyelinating disease MS and the animal model EAE.
Doty, Daniel J+7 more
core +1 more source
In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han+10 more
wiley +1 more source
Tuberculosis treatment in a refugee and migrant population: 20 years of experience on the Thai-Burmese border. [PDF]
Although tuberculosis (TB) is a curable disease, it remains a major global health problem and an important cause of morbidity and mortality among vulnerable populations, including refugees and ...
Bonnet, M+8 more
core +1 more source
Fatores prognósticos de letalidade da neurotuberculose em crianças HIV-negativas [PDF]
OBJECTIVE: To identify prognostic factors predicting a fatal outcome in HIV-negative children with neurotuberculosis based on clinical, epidemiological, and laboratory findings.
Lin, Jaime+4 more
core +3 more sources
Atypical Cerebral Manifestations of Disseminated Mycobacterium tuberculosis
BackgroundWe investigated the patterns of cerebral manifestations in patients with underlying pulmonary or extrapulmonary tuberculosis or disseminated tuberculosis.Materials and methodsFrom January 2010 to September 2016, brain magnetic resonance imaging
Ji Hye Hwang+6 more
doaj +1 more source
Anemia in tuberculosis cases: A biomarker of severity?
IntroductionAnemia is a common condition at tuberculosis diagnosis, and there is evidence that its prevalence is higher in patients with tuberculosis than in those infected with Mycobacterium tuberculosis and healthy controls.
Edson Beyker de Mendonça+6 more
doaj +1 more source
Paradoxical reaction to the treatment of tuberculosis uncovering previously silent meningeal disease
The development of paradoxical clinical worsening following initiation of tuberculosis treatment may complicate the clinical course of both HIV-infected and uninfected patients.
Walter A. Eyer-Silva+3 more
doaj
A rare case of tuberculous meningitis with pancreatitis
Tuberculous meningitis (TBM) is the most common form of central nervous system manifestation of tuberculosis. However, tuberculous pancreatitis is rarely reported. We present an 8-year-old female child with TBM who had intractable vomiting that persisted
Drishti Chandru Tolani, Ira Shah
doaj +1 more source
Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. [PDF]
BACKGROUND: Invasive fungal diseases (IFDs) remain important causes of morbidity and mortality. The consensus definitions of the Infectious Diseases Group of the European Organization for Research and Treatment of Cancer and the Mycoses Study Group have ...
Akan, H+64 more
core +5 more sources
Rare Infectious Diseases: Detection and Clinical Implications
Rare infectious diseases are infections that are uncommon, have a low incidence, and are caused by newly emerging pathogens, cross‐species or ectopic infections, or host immunodeficiencies. The detection and diagnosis of rare infections is one of the main reasons for misdiagnosis and missed diagnosis.
Xin Qian+7 more
wiley +1 more source