Results 41 to 50 of about 478,220 (238)

A robust SNP barcode for typing Mycobacterium tuberculosis complex strains [PDF]

, 2014
Strain-specific genomic diversity in the Mycobacterium tuberculosis complex (MTBC) is an important factor in pathogenesis that may affect virulence, transmissibility, host response and emergence of drug resistance.
A McKenna, A Stamatakis, B Langmead, B López, B Tessema, CB Ford, D Stucki, DR Zerbino, E Abadia, F Coll, F Coll, G Thwaites, H Li, H Zhang, I Comas, I Filliol, J Felsenstein, J Wang, JH Bates, M Caws, M Kato-Maeda, M Kato-Maeda, N Casali, P Nahid, PF Barnes, PL Lin, R Firdessa, S Feuerriegel, S Gagneux, S Homolka, T Derrien, T Weniger, TA Rado, Y Blouin   +33 more
core   +2 more sources

Multifocal Tuberculosis in Immunocompetent Children, Still A Current Problem: About 13 Cases

Scholars Journal of Medical Case Reports, 2023
Multifocal tuberculosis corresponds to involvement of at least two extra-pulmonary sites associated or not with pulmonary involvement. Material and Method: This is a retroprospective descriptive study of patients diagnosed with tuberculosis between 2018 ...
I. Hmimidi, I. Filali, S. Benchekroun, F. Benbrahim, N. Hafidi, C. Mahraoui   +5 more
semanticscholar   +1 more source

A Case of Extrapulmonary Tuberculosis Two-Ways [PDF]

, 2019
Tuberculosis (TB) is a widespread epidemic. The World HealthOrganization estimated 10.4 million cases of tuberculosis in 2016,with 490,000 new cases of multi-drug resistant (MDR) TB.1 Theprimary presentation of TB is pulmonary.
Cherabie, Joseph, Moore, Thomas A., Ojile, Nicolas   +2 more
core   +2 more sources

Meningeal TB in a 39-Year-Old Male Presenting with Headache

Case Reports in Infectious Diseases, 2017
Meningeal tuberculosis is rare in the developed world, with only 92 cases of meningeal TB reported in the United States in 2014 according to the CDC (CDC, 2015).
Jason Selinger, Thar El Baage
doaj   +1 more source

Gatifloxacin Pharmacokinetics/Pharmacodynamics-based Optimal Dosing for Pulmonary and Meningeal Multidrug-resistant Tuberculosis.

Clinical Infectious Diseases, 2018
Background Gatifloxacin is used for the treatment of multidrug-resistant tuberculosis (MDR-TB). The optimal dose is unknown. Methods We performed a 28-day gatifloxacin hollow-fiber system model of tuberculosis (HFS-TB) study in order to identify the ...
D. Deshpande, J. Pasipanodya, S. Srivastava, Paula Bendet, T. Koeuth, S. Bhavnani, P. Ambrose, W. Smythe, H. McIlleron, G. Thwaites, Mourad Gumusboga, A. Van Deun, T. Gumbo   +12 more
semanticscholar   +1 more source

Fluoroquinolones and isoniazid-resistant tuberculosis: implications for the 2018 WHO guidance. [PDF]

, 2019
INTRODUCTION: 2018 World Health Organization (WHO) guidelines for the treatment of isoniazid (H)-resistant (Hr) tuberculosis recommend a four-drug regimen: rifampicin (R), ethambutol (E), pyrazinamide (Z) and levofloxacin (Lfx), with or without H ([H]RZE-
Abbara, A, Abubakar, I, Alexander, E, Baker, LV, Barrett, JC, Booth, H, Bothamley, GH, Burgess, H, Cosgrove, C, Creer, DD, Davidson, JA, Dunleavy, A, Francis, M, Grp, LINH-RTBS, Gupta, U, Hamid, S, Harris, RJ, Haselden, BM, Holden, E, Kahr, V, Kon, OM, Kunst, H, Lalor, MK, Lipman, MC, Loebinger, MR, Loutet, MG, Lozewicz, S, Lynn, W, McHugh, TD, Milburn, HJ, Mohiyuddin, T, Palchaudhuri, P, Perrin, FM, Phillips, PPJ, Rahman, A, Schmok, E, Soobratty, MR, Stagg, HR, Taylor, L   +38 more
core   +4 more sources

Human tuberculosis - an ancient disease, as elucidated by ancient microbial biomolecules [PDF]

, 2009
Tuberculosis is a major cause of death but infected people with effective immunity may remain healthy for years, suggesting long-term coexistence of host and pathogen.
Donoghue, HD
core   +1 more source

Large-scale genomic analysis shows association between homoplastic genetic variation in Mycobacterium tuberculosis genes and meningeal or pulmonary tuberculosis

BMC Genomics, 2018
Meningitis is the most severe manifestation of tuberculosis. It is largely unknown why some people develop pulmonary TB (PTB) and others TB meningitis (TBM); we examined if the genetic background of infecting M. tuberculosis strains may be relevant.
C. Ruesen, L. Chaidir, A. van Laarhoven, S. Dian, A. Ganiem, H. Nebenzahl-Guimaraes, M. Huynen, B. Alisjahbana, B. Dutilh, R. van Crevel   +9 more
semanticscholar   +1 more source

Cerebro-Meningeal Tuberculosis in HIV-Negative Adults

Journal of Infectious Diseases and Epidemiology, 2018
Background: Tuberculosis remains a public health problem worldwide. Neurological localization is the most severe manifestation of extra-pulmonary tuberculosis characterized by a high mortality rate and a high rate of sequelae among survivors; its ...
W. Guenifi, A. Gasmi, H. Boukhrissa, M. Rais, A. Hachani, A. Ouyahia, S. Mechakra, A. Lacheheb   +7 more
semanticscholar   +1 more source

Standardized Methods for Enhanced Quality and Comparability of Tuberculous Meningitis Studies [PDF]

, 2016
Tuberculous meningitis (TBM) remains a major cause of death and disability in tuberculosis-endemic areas, especially in young children and immunocompromised adults.
Aarnoutse, Robert, Caws, Maxine, Figaji, Anthony, Hemmskerk, Anna D, Mai, Nguyen T H, Marais, Ben J, Marais, Suzaan S, McIlleron, Helen, Meintjes, Graeme, Misra, Usha K, Rohlwick, Ursula, Ruslami, Rovina, Schoeman, Johan F, Seddon, James A, Solomans, Regan, Thwaites, Guy E, van Crevel, Reinout, van Toorn, Ronald, Wilinson, Robert J   +18 more
core   +1 more source