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Management of Multidrug-Resistant Tuberculosis

Seminars in Respiratory and Critical Care Medicine, 2013
AbstractDrug-resistant strains of Mycobacterium tuberculosis pose a major threat to global tuberculosis control. Despite the availability of curative antituberculosis therapy for nearly half a century, inappropriate and inadequate treatment of tuberculosis, as well as unchecked transmission of M.
Charles L, Daley, Jose A, Caminero
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Linezolid for multidrug-resistant tuberculosis

The Lancet Infectious Diseases, 2013
In their Comment in The Lancet Infectious Diseases, Kwok-Chiu Chang and colleagues concluded that expansion of access to linezolid for complicated cases of drug-resistant tuberculosis risks the loss of a potentially useful drug and could promote the emergence and spread of drug-resistant tuberculosis in the community.
Helen, Cox   +3 more
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Multidrug-Resistant Tuberculosis Spondylitis

Acta Clinica Belgica, 2000
We report a case of multidrug-resistant spinal tuberculosis complicated by epiduritis and paraspinal abscess in a 68-year-old black woman. Multidrug-resistant tuberculous spondylitis is still rare in Belgium. Two others cases were reported from 1992 to 1997.
Cherifi, Soraya   +2 more
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Treatment and Prevention of Multidrug-Resistant Tuberculosis [PDF]

open access: possibleDrugs, 1999
Multidrug-resistant tuberculosis (MDRTB), which is defined as combined resistance to isoniazid and rifampicin, is a 'man-made' disease that is caused by improper treatment, inadequate drug supplies or poor patient supervision. Patients with MDRTB face chronic disability and death, and represent an infectious hazard for the community.
Bastian, I., Colebunders, R.
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Confronting Multidrug-Resistant Tuberculosis

New England Journal of Medicine, 2012
Microbial resistance to antituberculosis drugs has existed since the dawn of the antibiotic era.1 Multidrug-resistant (MDR) tuberculosis, defined by resistance to isoniazid and rifampin, requires treatment for up to 2 years with expensive second-line drugs that have poor side-effect profiles; success rates rarely exceed 65 to 75%.
Richard E, Chaisson, Eric L, Nuermberger
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Multidrug-resistant tuberculosis

Infectious Disease Clinics of North America, 2002
Multidrug-resistant TB is a growing public health problem. Although control of the multidrug-resistant TB epidemic has been achieved in New York City, strains of multidrug-resistant TB are found in nearly every state. Much of the world faces a growing problem with no immediate solution.
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Multidrug‐Resistant Tuberculosis

Annals of the New York Academy of Sciences, 2001
Abstract: The costs of multidrug‐resistant tuberculosis (MDR TB) reach far beyond the cost of the clinical treatment of the patient. The first impact of the discovery of MDR TB in a population is the need to recognize that all TB patients have the potential of being MDR.
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Multidrug resistance in Mycobacterium tuberculosis

International Journal of Antimicrobial Agents, 1997
All but one of the four major mechanisms of resistance to antimicrobial agents-inactivation of the drug, altered cell wall permeability or drug efflux, drug titration due to target overproduction, and alteration of the target by mutation-appear to be employed by Mycobacterium tuberculosis in its resistance to components of short course chemotherapy ...
Heym, B, Cole, S T
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Treatment of Multidrug-Resistant Tuberculosis

New England Journal of Medicine, 1993
The frequency of infections with M. tuberculosis resistant to antituberculous drugs is increasing in the United States and globally. This increase is a major threat to tuberculosis treatment and control programs. To prevent this situation from worsening, initial treatment programs that entail directly observed therapy supported by effective inducements
Alastair J.J. Wood, Michael D. Iseman
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▼Bedaquiline for multidrug-resistant tuberculosis

Drug and Therapeutics Bulletin, 2014
Resistance to drugs used to treat tuberculosis (TB) is a major public health problem that threatens progress made in TB management and control worldwide.1 It may result from improper use of antibiotics, including prescription of non-standard treatment regimens and poor adherence to drug therapy.
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