Results 231 to 240 of about 1,229,168 (350)

TRIPS and knowledge diffusion from low‐ and middle‐income countries

Strategic Management Journal, EarlyView.
Abstract Research Summary We examine a significant yet underappreciated effect of IPR implementation: the dissemination after TRIPS implementation of established scientific knowledge from low‐ and middle‐income countries (LMICs) into the global scientific system of pharmaceutical development.
Michael Blomfield, Anita M. McGahan, Keyvan Vakili   +2 more
wiley   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Deciphering the Heterogeneity of Pulmonary Macrophages in Response to Fine Particles

Small, EarlyView.
This study introduces a dual‐labeled gold nanoparticle model to capture particle–responsive cells via integrating fluorescence‐activated cell sorting and single‐cell RNA sequencing. Fourteen macrophage subsets are identified with response and function heterogeneity, among which AMs_3, AMs_7, and recMacs_4 subsets show stronger phagocytic activation ...
Qing'e Shan, Zheng Dong, Ning Li, Zijie Zhou, Jiayu Ren, Wei Liu, Feng Xu, Yu Qi, Juan Ma, Yi Liu, Shuping Zhang, Sijin Liu   +11 more
wiley   +1 more source

Analysis of Lymphocyte Immunologic Indexes in the Early Diagnosis of Active Pulmonary Tuberculosis of Adolescents in China. [PDF]

Infect Drug Resist
Zhang H, Yang L, Sun Y, Zhang Z, Zhou J.
europepmc   +1 more source

Transducer Systems Integrated into Organ‐on‐a‐Chip Devices: From Detection to Fabrication

Small, EarlyView.
This review outlines the importance and current challenges of the integration of several miniaturized transducers’ types in organ‐on‐a‐chip devices for nanomedicine and precision oncology applications. It also presents their transduction detection methods, currently design and fabrication techniques, used materials, integration approaches, and ...
Gabriel M. Ferreira, Patrícia C. Sousa, Susana O. Catarino, Graça Minas   +3 more
wiley   +1 more source

Identification of diagnostic and prognostic biomarkers for tuberculosis based on plasma proteomics. [PDF]

PLoS One
Hu Y, Quan C, Zhou Y, Liang S, Wang X, Li J, Liu W, Xu Y, Liu P.   +8 more
europepmc   +1 more source

Proteomic Profiling of Alveolar Macrophages Identifies Loss of Lysosomal Content as an Indicator of Nanofiber‐Induced Frustrated Phagocytosis

Small, EarlyView.
This proteomic study examines how nanofibers affect lung macrophages by analyzing protein changes following exposure to various fibrous materials. Nanofibers triggered the release of inflammatory enzymes, and importantly, lysosomal content release was identified as an early event associated with frustrated phagocytosis. Seventeen sensitive and relevant
Tobias Stobernack, Antje Vennemann, Carla Ribalta, Julia Schendel, Oliver Gräb, Rico Ledwith, Mario Pink, Andrea Haase, Martin Wiemann, Verónica I. Dumit   +9 more
wiley   +1 more source

Erythromycin Shortage in an NTM‐Endemic Country: Implications for Bronchiectasis Care and Antimicrobial Stewardship

Respirology, EarlyView.
Takanori Asakura, Ho Namkoong
wiley   +1 more source

Temporal and Spatial Organization in Collaborative Work by Nurses in an Emergency and Critical Care Center

Symbolic Interaction, EarlyView.
This study describes the work at an emergency and critical care center, focusing on the collaboration of multiple nurses when moving patients from the outpatient department to the ward. This study is an ethnomethodological ethnography based on fieldwork at a hospital and analysis of video data. The patient transport process is temporally organized into
Hiroki Maeda, Yumi Nishimura
wiley   +1 more source

Between‐country differences in the psychosocial profiles of British cattle farmers

Veterinary Record, EarlyView.
Abstract Background Psychosocial factors are important for the uptake of livestock disease control measures by farmers and can differ by region, which would have implications for disease control nationally. Methods We investigated altruism, trust, psychological proximity and the COM‐B behaviour change framework in a survey of 475 British cattle farmers
Naomi S. Prosser, Eamonn Ferguson, Jasmeet Kaler, Edward M. Hill, Michael J. Tildesley, Matt J. Keeling, Martin J. Green   +6 more
wiley   +1 more source