Results 21 to 30 of about 23,821 (165)

Enhanced expression of glucose transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target of rapamycin (mTOR)/ribosomal S6 protein kinase (S6K) pathway in experimental renal failure [PDF]

Journal of Vascular Surgery, 2013
Chronic renal failure (CRF) is associated with increased cardiovascular mortality, and medial vascular smooth muscle cell (VSMC) hypertrophy, proliferation, and calcification play a pivotal role in uremic vasculopathy. Glucose transporter-1 (GLUT1) facilitates the transport of glucose into VSMCs, and GLUT1 overexpression associated with high glucose ...
Lin, Chih-Yuan, Hsu, Shih-Che, Lee, Herng-Sheng, Lin, Shih-Hua, Tsai, Chien-Sung, Huang, Shih-Ming, Shih, Chun-Che, Hsu, Yu-Juei   +7 more
openaire   +2 more sources

Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4

Frontiers in Endocrinology, 2022
MicroRNAs expressed in adipocytes are involved in transcriptional regulation of target mRNAs in obesity, but miRNAs critically involved in this process is not well characterized.
Satoshi Yamaguchi, Dongxiao Zhang, Akihiro Katayama, Naoko Kurooka, Ryosuke Sugawara, Haya Hamed Hassan Albuayjan, Atsuko Nakatsuka, Jun Eguchi, Jun Wada   +8 more
doaj   +1 more source

Metformin Modulates T Cell Function and Alleviates Liver Injury Through Bioenergetic Regulation in Viral Hepatitis

Frontiers in Immunology, 2021
Metformin is not only the first-line medication for the treatment of type 2 diabetes, but it is also effective as an anti-inflammatory, anti-oxidative and anti-tumor agent. However, the effect of metformin during viral hepatitis remains elusive. Using an
Lanman Xu, Lanman Xu, Xiaofang Wang, Xiaofang Wang, Yan Chen, Lynn Soong, Lynn Soong, Lynn Soong, Yongping Chen, Jiyang Cai, Yuejin Liang, Yuejin Liang, Jiaren Sun, Jiaren Sun, Jiaren Sun   +14 more
doaj   +1 more source

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. [PDF]

PLoS ONE, 2009
BACKGROUND:Mammalian target of rapamycin complex 1 (mTORC1) is a protein kinase that relays nutrient availability signals to control numerous cellular functions including autophagy, a process of cellular self-eating activated by nutrient depletion ...
Aruna D Balgi, Bruno D Fonseca, Elizabeth Donohue, Trevor C F Tsang, Patrick Lajoie, Christopher G Proud, Ivan R Nabi, Michel Roberge   +7 more
doaj   +1 more source

ETV2 regulates PARP-1 binding protein to induce ER stress–mediated death in tuberin-deficient cells

Life Science Alliance, 2022
In tuberin-deficient cells, SYK regulates ETV2 nuclear translocation, where it regulated Parpbp expression. Silencing Etv2 or Parpbp induces ER stress–mediated cell death in tuberin-deficient cells.
Shikshya Shrestha, Anthony Lamattina, Gustavo Pacheco-Rodriguez, Julie Ng, Xiaoli Liu, Abhijeet Sonawane, Jewel Imani, Weiliang Qiu, Kosmas Kosmas, Pierce Louis, Anne Hentschel, Wendy K Steagall, Rieko Onishi, Helen Christou, Elizabeth P Henske, Kimberly Glass, Mark A Perrella, Joel Moss, Kelan Tantisira, Souheil El-Chemaly   +19 more
doaj   +1 more source

Drug Inhibition of Redox Factor-1 Restores Hypoxia-Driven Changes in Tuberous Sclerosis Complex 2 Deficient Cells

Cancers, 2022
Simple Summary Tuberous sclerosis complex (TSC) is a genetic disease where patients are predisposed to tumors and neurological complications. Current therapies for this disease are not fully curative.
Jesse D Champion, K. Dodd, H. Lam, M. A. Alzahrani, Sara Seifan, Ellie Rad, D. O. Scourfield, M. Fishel, B. Calver, A. Ager, E. Henske, D. M. Davies, M. Kelley, Andrew R. Tee   +13 more
semanticscholar   +1 more source

Tuberous sclerosis complex protein 1 expression is affected by VHL Gene alterations and HIF-1α production in sporadic clear-cell renal cell carcinoma

Experimental and Molecular Pathology, 2016
Alterations in von Hippel-Lindau gene (VHL) do not determine deregulation of hypoxia-inducible factors (HIFs) in clear-cell renal carcinoma (ccRCC). Their effects on tuberous sclerosis proteins (TSC1/2) and heat shock protein 90 (Hsp90) expressions in sporadic ccRCC are unknown.
Svetozar S, Damjanovic, Bojana B, Ilic, Bojana B, Beleslin Cokic, Jadranka A, Antic, Jovana Z, Bankovic, Ivana T, Milicevic, Gordana S, Rodic, Dusan S, Ilic, Vera N, Todorovic, Nela, Puskas, Cane D, Tulic   +10 more
openaire   +2 more sources

Deletion of tuberous sclerosis complex 1 (TSC1) in limb bud mesenchyme causes chondrodysplasia and severe knee joint osteoarthritis in mice

, 2020
The tumor suppressor genes, tuberous sclerosis complex 1 (TSC1) and TSC2, encode hamartin and tuberin, respectively, which are key upstream negative regulators of the mechanistic target of rapamycin complex 1 (mTORC1) (1-3).
Pinglin Lai, Jiansen Lu, X. Bai, D. Cai
semanticscholar   +1 more source

The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels

Cell Reports, 2017
Summary: Mechanistic (or mammalian) target of rapamycin complex 1 (mTORC1) integrates signals from growth factors and nutrients to control biosynthetic processes, including protein, lipid, and nucleic acid synthesis.
Gerta Hoxhaj, James Hughes-Hallett, Rebecca C. Timson, Erika Ilagan, Min Yuan, John M. Asara, Issam Ben-Sahra, Brendan D. Manning   +7 more
doaj   +1 more source

Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice [PDF]

Open Biology, 2019
Osteocytes secrete the glycoprotein sclerostin to inhibit bone formation by osteoblasts, but how sclerostin production is regulated in osteocytes remains unclear.
Wen Liu, Zhenyu Wang, Jun Yang, Yongkui Wang, Kai Li, Bin Huang, Bo Yan, Ting Wang, Mangmang Li, Zhipeng Zou, Jian Yang, Guozhi Xiao, Zhong-Kai Cui, Anling Liu, Xiaochun Bai   +14 more
doaj   +1 more source