Results 31 to 40 of about 23,821 (165)

Microglial ASD-related genes are involved in oligodendrocyte differentiation

Scientific Reports, 2021
Autism spectrum disorders (ASD) are associated with mutations of chromodomain-helicase DNA-binding protein 8 (Chd8) and tuberous sclerosis complex 2 (Tsc2).
Yuta Takanezawa, Shogo Tanabe, Daiki Kato, Rie Ozeki, Masayo Komoda, Tatsunori Suzuki, Hiroko Baba, Rieko Muramatsu   +7 more
doaj   +1 more source

Architecture of the Tuberous Sclerosis Protein Complex

bioRxiv, 2020
The Tuberous Sclerosis Complex (TSC) protein complex (TSCC), comprising of three subunits TSC1, TSC2, and TBC1D7, is widely recognised as a key integration hub for cell growth and intracellular stress signals upstream of the mammalian target of rapamycin
K. Ramlaul, W. Fu, Hua Li, N. de Martín Garrido, Lin He, W. Cui, Christopher H. S. Aylett, Geng Wu   +7 more
semanticscholar   +1 more source

mTOR pathway – a potential therapeutic target in stroke

Therapeutic Advances in Neurological Disorders, 2023
Stroke is ranked as the second leading cause of death worldwide and a major cause of long-term disability. A potential therapeutic target that could offer favorable outcomes in stroke is the mammalian target of rapamycin (mTOR) pathway.
Konstantinos Melanis, Maria-Ioanna Stefanou, Konstantinos M. Themistoklis, Themistoklis Papasilekas   +3 more
doaj   +1 more source

Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex

Cell Reports, 2014
The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a sensor of different environmental conditions and regulator of cell growth, metabolism, and autophagy.
Anita Parmigiani, Aida Nourbakhsh, Boxiao Ding, Wei Wang, Young Chul Kim, Konstantin Akopiants, Kun-Liang Guan, Michael Karin, Andrei V. Budanov   +8 more
doaj   +1 more source

Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex

Human Genomics, 2023
Background Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that is associated with neurological symptoms, including autism spectrum disorder.
Hirofumi Kashii, Shinya Kasai, Atsushi Sato, Yoko Hagino, Yasumasa Nishito, Toshiyuki Kobayashi, Okio Hino, Masashi Mizuguchi, Kazutaka Ikeda   +8 more
doaj   +1 more source

A systems biology approach to define mechanisms, phenotypes, and drivers in PanNETs with a personalized perspective

npj Systems Biology and Applications, 2023
Pancreatic neuroendocrine tumors (PanNETs) are a rare tumor entity with largely unpredictable progression and increasing incidence in developed countries.
Silke D. Werle, Nensi Ikonomi, Ludwig Lausser, Annika M. T. U. Kestler, Felix M. Weidner, Julian D. Schwab, Julia Maier, Malte Buchholz, Thomas M. Gress, Angelika M. R. Kestler, Hans A. Kestler   +10 more
doaj   +1 more source

Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.

PLoS ONE, 2009
BackgroundThe signaling pathways imposing hormonal control over adipocyte differentiation are poorly understood. While insulin and Akt signaling have been found previously to be essential for adipogenesis, the relative importance of their many downstream
Hui H Zhang, Jingxiang Huang, Katrin Düvel, Bernard Boback, Shulin Wu, Rachel M Squillace, Chin-Lee Wu, Brendan D Manning   +7 more
doaj   +1 more source

Mechanisms of TSC-mediated control of synapse assembly and axon guidance. [PDF]

PLoS ONE, 2007
Tuberous sclerosis complex is a dominant genetic disorder produced by mutations in either of two tumor suppressor genes, TSC1 and TSC2; it is characterized by hamartomatous tumors, and is associated with severe neurological and behavioral disturbances ...
Sarah Knox, Hong Ge, Brian D Dimitroff, Yi Ren, Katie A Howe, Andrew M Arsham, Mathew C Easterday, Thomas P Neufeld, Michael B O'Connor, Scott B Selleck   +9 more
doaj   +1 more source

The Neurodevelopmental Pathogenesis of Tuberous Sclerosis Complex (TSC)

Frontiers in Neuroanatomy, 2020
Tuberous sclerosis complex (TSC) is a model disorder for understanding brain development because the genes that cause TSC are known, many downstream molecular pathways have been identified, and the resulting perturbations of cellular events are ...
David M. Feliciano
semanticscholar   +1 more source

PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. [PDF]

PLoS ONE, 2007
TOR (Target of Rapamycin) is a highly conserved protein kinase and a central controller of cell growth. TOR is found in two functionally and structurally distinct multiprotein complexes termed TOR complex 1 (TORC1) and TOR complex 2 (TORC2).
Kathrin Thedieck, Pazit Polak, Man Lyang Kim, Klaus D Molle, Adiel Cohen, Paul Jenö, Cécile Arrieumerlou, Michael N Hall   +7 more
doaj   +1 more source