Results 11 to 20 of about 31,123,995 (208)

Effectiveness and safety of cannabidiol in adult patients with epilepsy: A multicenter, retrospective study. [PDF]

Epilepsia Open
Abstract Objective Cannabidiol (CBD) has demonstrated promising effectiveness and tolerability as adjunctive treatment in patients with severe childhood epilepsies. This study investigated the effectiveness and tolerability of CBD in adults with a history of Dravet syndrome (DS), Lennox–Gastaut syndrome (LGS), or tuberous sclerosis complex (TSC ...
Sánchez-Gamino S, Chamorro Muñoz MI, Serrano-Castro PJ, Hernández-Vitorique P, Rodríguez Jiménez L, López Moreno Y, Cabezudo-García P, García Martín G.   +7 more
europepmc   +2 more sources

Abnormal KCC2 expression and function in a mouse model of epilepsy and tuberous sclerosis complex. [PDF]

Epilepsia
Abstract Objective Drug‐resistant epilepsy is a common, severe manifestation of the genetic disorder tuberous sclerosis complex (TSC). Although significant mechanistic and therapeutic advances have been made in TSC, treatments for seizures remain largely ineffective.
Guo D, Han L, Rensing NR, Jansen LA, Wong M.   +4 more
europepmc   +2 more sources

Tuberous Sclerosis Complex Proteins 1 and 2 Control Serum-Dependent Translation in a TOP-Dependent and -Independent Manner [PDF]

Molecular and Cellular Biology, 2007
The tuberous sclerosis complex (TSC) proteins TSC1 and TSC2 regulate protein translation by inhibiting the serine/threonine kinase mTORC1 (for mammalian target of rapamycin complex 1). However, how TSC1 and TSC2 control overall protein synthesis and the translation of specific mRNAs in response to different mitogenic and nutritional stimuli is largely ...
Benoit, Bilanges, Rhoda, Argonza-Barrett, Marina, Kolesnichenko, Christina, Skinner, Manoj, Nair, Michelle, Chen, David, Stokoe   +6 more
openaire   +2 more sources

Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2) [PDF]

Biochemical Journal, 2005
The hypertrophic Gq-protein-coupled receptor agonist PE (phenylephrine) activates protein synthesis. We showed previously that activation of protein synthesis by PE requires MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase] and mTOR (mammalian target of rapamycin).
Rolfe, M., McLeod, L.E., Pratt, P.F., Proud, C.G.   +3 more
openaire   +3 more sources

Polymerized Collagen Inhibits Fibroblast Proliferation via a Mechanism Involving the Formation of a β1 Integrin-Protein Phosphatase 2A-Tuberous Sclerosis Complex 2 Complex That Suppresses S6K1 Activity [PDF]

Journal of Biological Chemistry, 2008
Polymerized type I collagen suppresses fibroblast proliferation. Previous studies have implicated inhibition of fibroblast proliferation with polymerized collagen-mediated suppression of S6K1, but the molecular mechanism of the critical negative feedback loop has not yet been fully elucidated. Here, we demonstrate that polymerized collagen suppresses G(
Hong, Xia, Richard, Nho, Jill, Kleidon, Judy, Kahm, Craig A, Henke   +4 more
openaire   +2 more sources

Microglial ASD-related genes are involved in oligodendrocyte differentiation

Scientific Reports, 2021
Autism spectrum disorders (ASD) are associated with mutations of chromodomain-helicase DNA-binding protein 8 (Chd8) and tuberous sclerosis complex 2 (Tsc2).
Yuta Takanezawa, Shogo Tanabe, Daiki Kato, Rie Ozeki, Masayo Komoda, Tatsunori Suzuki, Hiroko Baba, Rieko Muramatsu   +7 more
doaj   +1 more source

ETV2 regulates PARP-1 binding protein to induce ER stress–mediated death in tuberin-deficient cells

Life Science Alliance, 2022
In tuberin-deficient cells, SYK regulates ETV2 nuclear translocation, where it regulated Parpbp expression. Silencing Etv2 or Parpbp induces ER stress–mediated cell death in tuberin-deficient cells.
Shikshya Shrestha, Anthony Lamattina, Gustavo Pacheco-Rodriguez, Julie Ng, Xiaoli Liu, Abhijeet Sonawane, Jewel Imani, Weiliang Qiu, Kosmas Kosmas, Pierce Louis, Anne Hentschel, Wendy K Steagall, Rieko Onishi, Helen Christou, Elizabeth P Henske, Kimberly Glass, Mark A Perrella, Joel Moss, Kelan Tantisira, Souheil El-Chemaly   +19 more
doaj   +1 more source

Enhanced expression of glucose transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target of rapamycin (mTOR)/ribosomal S6 protein kinase (S6K) pathway in experimental renal failure [PDF]

Journal of Vascular Surgery, 2013
Chronic renal failure (CRF) is associated with increased cardiovascular mortality, and medial vascular smooth muscle cell (VSMC) hypertrophy, proliferation, and calcification play a pivotal role in uremic vasculopathy. Glucose transporter-1 (GLUT1) facilitates the transport of glucose into VSMCs, and GLUT1 overexpression associated with high glucose ...
Lin, Chih-Yuan, Hsu, Shih-Che, Lee, Herng-Sheng, Lin, Shih-Hua, Tsai, Chien-Sung, Huang, Shih-Ming, Shih, Chun-Che, Hsu, Yu-Juei   +7 more
openaire   +2 more sources

mTOR pathway – a potential therapeutic target in stroke

Therapeutic Advances in Neurological Disorders, 2023
Stroke is ranked as the second leading cause of death worldwide and a major cause of long-term disability. A potential therapeutic target that could offer favorable outcomes in stroke is the mammalian target of rapamycin (mTOR) pathway.
Konstantinos Melanis, Maria-Ioanna Stefanou, Konstantinos M. Themistoklis, Themistoklis Papasilekas   +3 more
doaj   +1 more source

Identification of a region required for TSC1 stability by functional analysis of TSC1 missense mutations found in individuals with tuberous sclerosis complex [PDF]

, 2009
Background: Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterised by the development of hamartomas in a variety of organs and tissues.
Povey, S, Ekong, Rosemary, David Kwiatkowski, Ans van den Ouweland, Nellist Mark, Halley Dicky, Povey Sue, Sampson, J. (Julian), Povey, S. (Sue), Kwiatkowski, D. (David), Melika Mozaffari, Sampson, Julian Roy, Halley, D, Sampson Julian, Dunnen, JT, Ekong Rosemary, Ekong, R, Nellist, Mark, Sampson, J, van den Ouweland, Ans, Dunnen, J.T. (Johan) den, Dicky Halley, van den Ouweland Ans, Hoogeveen-Westerveld, M. (Marianne), Halley, Dicky, Halley, D.J.J. (Dicky), den Dunnen, Johan T., Johan T den Dunnen, Rosemary Ekong, Sue Povey, Ekong, R. (Rosemary), Nellist, M.D. (Mark), Hoogeveen-Westerveld, M, Ouweland, A.M.W. (Ans) van den, Hoogeveen - Westerveld, Marianne, Mark Nellist, Nellist, M, Povey, Sue, den Dunnen Johan T, Mozaffari, M, Kwiatkowski, David, Kwiatkowski, D, Mozaffari Melika, Julian Sampson, Mozaffari, E. (Melika), Hoogeveen-Westerveld Marianne, van den Ouweland, A, Marianne Hoogeveen-Westerveld, Mozaffari, Melika, Kwiatkowski David, den Dunnen, JT, Hoogeveen-Westerveld, Marianne   +51 more
core   +2 more sources