Results 21 to 30 of about 18,866 (220)
Regulation of the mammalian target of rapamycin complex 2 (mTORC2) [PDF]
, 2006 The growth controlling mammalian Target of Rapamycin (mTOR) is a conserved Ser/Thr kinase found in two structurally and functionally distinct complexes, mTORC1 and mTORC2.
Molle, Klaus-Dieter
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mTOR pathway – a potential therapeutic target in stroke
Therapeutic Advances in Neurological Disorders, 2023 Stroke is ranked as the second leading cause of death worldwide and a major cause of long-term disability. A potential therapeutic target that could offer favorable outcomes in stroke is the mammalian target of rapamycin (mTOR) pathway.
Konstantinos Melanis +3 more
doaj +1 more source
Single serine on TSC2 exerts biased control over mTORC1 activation mediated by ERK1/2 but not Akt
Life Science Alliance, 2022 Both ERK1/2 and Akt kinases activate mTORC1, but only the former is bidirectionally regulated by the status of serine S1364 on TSC2 that confers input-selective mTORC1 amplification or attenuation. Tuberous sclerosis complex-2 (TSC2) negatively regulates
Brittany L Dunkerly-Eyring +8 more
doaj +1 more source
Frontiers in Immunology, 2021 Metformin is not only the first-line medication for the treatment of type 2 diabetes, but it is also effective as an anti-inflammatory, anti-oxidative and anti-tumor agent. However, the effect of metformin during viral hepatitis remains elusive. Using an
Lanman Xu +14 more
doaj +1 more source
Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling [PDF]
, 2009 BackgroundMammalian target of rapamycin complex 1 (mTORC1) is a protein kinase that relays nutrient availability signals to control numerous cellular functions including autophagy, a process of cellular self-eating activated by nutrient depletion ...
Trevor C F Tsang +31 more
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Function of mTOR complex 1 and 2 in skeletal muscle [PDF]
, 2009 Growth of an organ during development and during adaptation in the adult can be controlled by alterations either in the number or the size of cells. The two mechanisms are fundamentally different and require distinct regulation.
Bentzinger, Conrad Florian
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Regulation of the mTOR/S6K pathway by cellular energy [PDF]
, 2009 The mammalian target of rapamycin (mTOR) signaling pathway integrates positive and negative signals that control cellular growth, metabolism and survival. mTOR exists in two different complexes, mTOR Complex1 and mTOR Complex2.
Kalender, Adem
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PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. [PDF]
PLoS ONE, 2007 TOR (Target of Rapamycin) is a highly conserved protein kinase and a central controller of cell growth. TOR is found in two functionally and structurally distinct multiprotein complexes termed TOR complex 1 (TORC1) and TOR complex 2 (TORC2).
Kathrin Thedieck +7 more
doaj +1 more source
Characterization of TOR complex 2 (TORC2) in "Saccharomyces cerevisiae" [PDF]
, 2004 The TOR proteins play a central role in the control of cell growth. TOR proteins are the founding members of the phosphatidylinositol-related kinase (PIKK) family of protein kinases. In S. cerevisiae there are two TOR proteins, TOR1 and TOR2.
Wullschleger, Stephan
core +1 more source
Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.
PLoS ONE, 2009 BackgroundThe signaling pathways imposing hormonal control over adipocyte differentiation are poorly understood. While insulin and Akt signaling have been found previously to be essential for adipogenesis, the relative importance of their many downstream
Hui H Zhang +7 more
doaj +1 more source