Results 21 to 30 of about 31,123,995 (208)

Single serine on TSC2 exerts biased control over mTORC1 activation mediated by ERK1/2 but not Akt

Life Science Alliance, 2022
Both ERK1/2 and Akt kinases activate mTORC1, but only the former is bidirectionally regulated by the status of serine S1364 on TSC2 that confers input-selective mTORC1 amplification or attenuation. Tuberous sclerosis complex-2 (TSC2) negatively regulates
Brittany L Dunkerly-Eyring, Shi Pan, Miguel Pinilla-Vera, Desirae McKoy, Sumita Mishra, Maria I Grajeda Martinez, Christian U Oeing, Mark J Ranek, David A Kass   +8 more
doaj   +1 more source

Regulation of the mammalian target of rapamycin complex 2 (mTORC2) [PDF]

, 2006
The growth controlling mammalian Target of Rapamycin (mTOR) is a conserved Ser/Thr kinase found in two structurally and functionally distinct complexes, mTORC1 and mTORC2.
Molle, Klaus-Dieter
core   +1 more source

Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex

Human Genomics, 2023
Background Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that is associated with neurological symptoms, including autism spectrum disorder.
Hirofumi Kashii, Shinya Kasai, Atsushi Sato, Yoko Hagino, Yasumasa Nishito, Toshiyuki Kobayashi, Okio Hino, Masashi Mizuguchi, Kazutaka Ikeda   +8 more
doaj   +1 more source

Metformin Modulates T Cell Function and Alleviates Liver Injury Through Bioenergetic Regulation in Viral Hepatitis

Frontiers in Immunology, 2021
Metformin is not only the first-line medication for the treatment of type 2 diabetes, but it is also effective as an anti-inflammatory, anti-oxidative and anti-tumor agent. However, the effect of metformin during viral hepatitis remains elusive. Using an
Lanman Xu, Lanman Xu, Xiaofang Wang, Xiaofang Wang, Yan Chen, Lynn Soong, Lynn Soong, Lynn Soong, Yongping Chen, Jiyang Cai, Yuejin Liang, Yuejin Liang, Jiaren Sun, Jiaren Sun, Jiaren Sun   +14 more
doaj   +1 more source

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling [PDF]

, 2009
BackgroundMammalian target of rapamycin complex 1 (mTORC1) is a protein kinase that relays nutrient availability signals to control numerous cellular functions including autophagy, a process of cellular self-eating activated by nutrient depletion ...
Trevor C F Tsang, Roberge, Michel, Bruno D Fonseca, Patrick Lajoie, Tsang, Trevor C. F., Lajoie, Patrick, Proud, Christopher G., Aruna D Balgi, Michel Roberge, Tsang Trevor C. F., Ivan R Nabi, Lajoie, P., Nabi Ivan R., Fonseca, B., Balgi, Aruna D., Fonseca, Bruno D., Proud, C., Tsang, T., Balgi, A., Nabi, Ivan R., Roberge, M., Balgi Aruna D., Proud Christopher G., Lajoie Patrick, Roberge Michel, Donohue, Elizabeth, Christopher G Proud, Donohue Elizabeth, Nabi, I., Fonseca Bruno D., Donohue, E., Elizabeth Donohue   +31 more
core   +2 more sources

Novel Mutation in the TSC2 Gene Associated with Prenatally Diagnosed Cardiac Rhabdomyomas and Cerebral Tuberous Sclerosis

Journal of the Formosan Medical Association, 2006
Cardiac rhabdomyomas are prenatal echocardiographic markers for tuberous sclerosis complex (TSC). TSC is caused by mutations in the genes TSC1 and TSC2.
Chih-Ping Chen, Yi-Ning Su, Chia-Cheng Hung, Jin-Chung Shih, Wayseen Wang   +4 more
doaj   +1 more source

PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. [PDF]

PLoS ONE, 2007
TOR (Target of Rapamycin) is a highly conserved protein kinase and a central controller of cell growth. TOR is found in two functionally and structurally distinct multiprotein complexes termed TOR complex 1 (TORC1) and TOR complex 2 (TORC2).
Kathrin Thedieck, Pazit Polak, Man Lyang Kim, Klaus D Molle, Adiel Cohen, Paul Jenö, Cécile Arrieumerlou, Michael N Hall   +7 more
doaj   +1 more source

Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.

PLoS ONE, 2009
BackgroundThe signaling pathways imposing hormonal control over adipocyte differentiation are poorly understood. While insulin and Akt signaling have been found previously to be essential for adipogenesis, the relative importance of their many downstream
Hui H Zhang, Jingxiang Huang, Katrin Düvel, Bernard Boback, Shulin Wu, Rachel M Squillace, Chin-Lee Wu, Brendan D Manning   +7 more
doaj   +1 more source

Cardiovascular considerations in tuberous sclerosis [PDF]

, 2017
Tuberous sclerosis complex is a genetic condition with an autosomal dominant pattern of inheritance, with an incidence of approximately 1:10,000, and 1:6,800 in the paediatric population, caused by a mutation of either of two genes: TSC1 on chromosome ...
Mazurek, Bogusław, Lesław Szydłowski, Joanna Kohut, Bogusław Mazurek, Aleksandra Morka, Jacek Pająk, Pająk, Jacek, Kohut, Joanna, Szydłowski, Lesław, Morka, Aleksandra   +9 more
core   +1 more source

Inhibition of ERK1/2 Restores GSK3β Activity and Protein Synthesis Levels in a Model of Tuberous Sclerosis

Scientific Reports, 2017
Tuberous sclerosis (TS) is a multi-organ autosomal dominant disorder that is best characterized by neurodevelopmental deficits and the presence of benign tumors.
Rituraj Pal, Vitaliy V. Bondar, Carolyn J. Adamski, George G. Rodney, Marco Sardiello   +4 more
doaj   +1 more source