Results 31 to 40 of about 31,123,995 (208)
Function of mTOR complex 1 and 2 in skeletal muscle [PDF]
, 2009 Growth of an organ during development and during adaptation in the adult can be controlled by alterations either in the number or the size of cells. The two mechanisms are fundamentally different and require distinct regulation.
Bentzinger, Conrad Florian
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Regulation of the mTOR/S6K pathway by cellular energy [PDF]
, 2009 The mammalian target of rapamycin (mTOR) signaling pathway integrates positive and negative signals that control cellular growth, metabolism and survival. mTOR exists in two different complexes, mTOR Complex1 and mTOR Complex2.
Kalender, Adem
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Regulation of colonic epithelial cell homeostasis by mTORC1
Scientific Reports, 2020 Cell signaling important for homeostatic regulation of colonic epithelial cells (CECs) remains poorly understood. Mammalian target of rapamycin complex 1 (mTORC1), a protein complex that contains the serine-threonine kinase mTOR, mediates signaling that ...
Takenori Kotani +8 more
doaj +1 more source
Molecular Pain, 2023 Neuropathic pain is a common dose-limiting side effect of oxaliplatin, which hampers the effective treatment of tumors. Here, we found that upregulation of transcription factor NFATc2 decreased the expression of Beclin-1, a critical molecule in autophagy,
Meng Liu +7 more
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Visual Evoked Potentials as a Readout of Cortical Function in Infants With Tuberous Sclerosis Complex [PDF]
, 2015 Tuberous sclerosis complex is an autosomal dominant genetic disorder that confers a high risk for neurodevelopmental disorders, such as autism spectrum disorder and intellectual disability.
Varcin, Kandice J +11 more
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Characterization of TOR complex 2 (TORC2) in "Saccharomyces cerevisiae" [PDF]
, 2004 The TOR proteins play a central role in the control of cell growth. TOR proteins are the founding members of the phosphatidylinositol-related kinase (PIKK) family of protein kinases. In S. cerevisiae there are two TOR proteins, TOR1 and TOR2.
Wullschleger, Stephan
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Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy
Cell Reports, 2017 Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder characterized by mutations in either the TSC1 or TSC2 genes, whose products form a critical inhibitor of the mechanistic target of rapamycin (mTOR). Loss of TSC1/2 gene function renders an
Jonathan O. Lipton +8 more
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Review of Tuberous Sclerosis Complex: A Single Center Experience
, 2021 Aim:The aim of this study is to review the clinical features and treatment of tuberous sclerosis complex patients followed up in our hospital and to compare our findings with the literature.Materials and Methods:The clinical-laboratory findings and ...
Ayşe Tosun +5 more
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Viruses, 2016 Porcine circovirus type 2 (PCV2) induces autophagy via the 5′ adenosine monophosphate-activated protein kinase (AMPK)/extracellular signal-regulated kinase (ERK)/tuberous sclerosis complex 2 (TSC2)/mammalian target of rapamycin (mTOR) pathway in pig ...
Yuanxing Gu +6 more
doaj +1 more source
Pilot validation of the Tuberous Sclerosis Associated Neuropsychiatric Disorders (TAND) checklist as a screening tool for neuropsychiatric manifestations [PDF]
, 2014 Includes abstract.
Leclezio, Loren
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