Results 131 to 140 of about 436,730 (400)
Combined antitumoral effects of pretubulysin and methotrexate
Pharmacology Research & Perspectives, 2019 Pretubulysin (PT), a potent tubulin‐binding antitumoral drug, and the well‐established antimetabolite methotrexate (MTX) were tested separately or in combination (PT+MTX) for antitumoral activity in L1210 leukemia cells or KB cervix carcinoma cells in ...
Sarah Kern +7 more
doaj +1 more source
Frontiers in Oncology, 2019 Microtubules are important drug targets in tumor cells, owing to their role in supporting and determining the cell shape, organelle movement and cell division.
Natalia Girola +9 more
doaj +1 more source
Interaction of diazonamide A with tubulin
Archives of Biochemistry and Biophysics, 2020 [3H]Diazonamide A ([3H]DZA), prepared from the natural product isolated from Diazona angulata, bound to tubulin in larger aberrant assembly products (>500 kDa by sizing HPLC) but not to the αβ-tubulin heterodimer. The binding reaction was rapid, but stoichiometry was low.
Bai, Ruoli +4 more
openaire +5 more sources
Self-Organized Networks with Long-Range Interactions: Tandem Darwinian Evolution of $α$ and $β$ Tubulin [PDF]
arXiv, 2020 Cytoskeletons are self-organized networks based on polymerized proteins: actin, tubulin, and driven by motor proteins, such as myosin, kinesin and dynein. Their positive Darwinian evolution enables them to approach optimized functionality (self-organized criticality).
arxiv
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
Mitogenome and Nuclear-encoded Fungicide-target Genes of Thecaphora frezii - Causal Agent of Peanut Smut [PDF]
, 2019 Background: Thecaphora frezii Carranza and Lindquist causes smut disease in peanut (Arachis hypogaea L.) resulting in up to 35% yield losses. Fungicides have shown ineffective in controlling the disease; whereas research on the molecular basis of that ...
Arias, Renee S. +12 more
core +2 more sources
Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule
Nature Communications, 2016 Molecules that alter the normal dynamics of microtubule assembly and disassembly include many anticancer drugs in clinical use. So far all such therapeutics target β-tubulin, and structural biology has explained the basis of their action and permitted ...
Jianhong Yang +10 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.This study introduces a conductive nerve guidance conduit integrated with wireless electrical stimulation through alternating magnetic fields, which induces currents and creates a supportive microenvironment for nerve regeneration. In vivo studies show that this approach significantly enhanced myelin restoration, gastrocnemius muscle regeneration ...
Shiheng Liu +7 more
wiley +1 more source
Supersymmetric methods in the traveling variable: inside neurons and at the brain scale [PDF]
, 2007 We apply the mathematical technique of factorization of differential operators to two different problems. First we review our results related to the supersymmetry of the Montroll kinks moving onto the microtubule walls as well as mentioning the sine ...
Cornejo-Perez, O. +2 more
core +2 more sources
Tubulin transport by IFT is upregulated during ciliary growth by a cilium-autonomous mechanism
Journal of Cell Biology, 2015 In Chlamydomonas cilia, IFT concentrates soluble tubulin by regulating IFT train occupancy and thereby promotes elongation of axonemal microtubules.
Julie M. Craft +4 more
semanticscholar +1 more source