Results 111 to 120 of about 290,382 (301)
Advanced Science, EarlyView.Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia +17 more
wiley +1 more source
Tubulin-binding agents down-regulate matrix metalloproteinase-2 and-9 in human hormone-refractory prostate cancer cells - A critical role of Cdk1 in mitotic entry [PDF]
, 2017 Tubulin is an important target for anticancer therapy. Taxanes and vinca alkaloids are two groups of tubulin-binding agents in cancer chemotherapy.
顧記華 +1 more
core +1 more source
A Whole‐Head Finite Element Model for Electrical Neuromodulation via Visual Brain‐Machine Interfaces
Advanced Science, EarlyView.A multimodal, personalized head model is presented that integrates the entire visual pathway with surrounding tissues to simulate electrical stimulation of the optic nerve. In vivo validation in humans and goats, plus systematic component‐elimination analysis, demonstrates the high accuracy of the comprehensive model.
Shengjian Lu +12 more
wiley +1 more source
Advanced Science, EarlyView.The sea cucumber Holothuria leucospilota detects blue and adjacent wavelengths of light via an r‐opsin with a maximum absorption at 459 nm. In the oral tentacles, papillae, and tube feet, distinct light‐sensing structures with specialized morphologies are formed, constituting a unique pentaradial and bilateral combined photoreception system.
Jiasheng Huang +20 more
wiley +1 more source
Mutation in beta1-tubulin correlates with macrothrombocytopenia in Cavalier King Charles Spaniels. [PDF]
, 2008 BACKGROUND Cavalier King Charles Spaniels (CKCS) have a high prevalence of inherited macrothrombocytopenia. The purpose of this study was to determine if a mutation in beta1-tubulin correlated with presumptive inherited macrothrombocytopenia ...
Schuller, Simone +3 more
core +1 more source
Advanced Science, EarlyView.SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang +17 more
wiley +1 more source
Tubulin in MT formation. [PDF]
, 2013 (A) Tubulin dimer. Light grey –α-tubulin, Dark Grey – β-tubulin. C-terminal tails extend from the main tubulin body. (B) B-lattice MT with protofilament highlighted. (C) Tubulin interactions in MT formation.
Travis J. A. Craddock (318229) +6 more
core +1 more source
Advanced Science, EarlyView.A multimodal intravital imaging platform enables longitudinal tracking of human cortical organoids transplanted into chronic stroke lesions. By combining surgical microscopy, MRI, bioluminescence imaging, and two‐photon fluorescence microscopy, the platform captures graft placement, viability dynamics, and cellular‐scale morphology in vivo, offering a ...
Jinghui Wang +12 more
wiley +1 more source
Cytoskeletal scaffolds in neuronal development [PDF]
, 2019 Neuronal polarization is one of the most studied topics in neuroscience. In less than seven days neurites sprout out from the neuron, explore the surrounding environment and mature in axon or dendrites.
Mortal, Simone
core
Tubulin acetylation and deacetylation. [PDF]
, 2013 (a) Schematic representation of the acetylation and deacetylation of microtubules by αTAT and HDAC6, respectively. (b) Western blots of non-treated, acetylated, and deacetylated tubulin with anti-b-tubulin (SAP4G5, Abnova), anti-AcK40 (6–11B-1, Thermo ...
Elisabeth Fischermeier (312999) +3 more
core +1 more source