Results 131 to 140 of about 289,598 (269)

Rapid binding to protofilament edge sites facilitates tip tracking of EB1 at growing microtubule plus-ends

eLife
EB1 is a key cellular protein that delivers regulatory molecules throughout the cell via the tip-tracking of growing microtubule plus-ends. Thus, it is important to understand the mechanism for how EB1 efficiently tracks growing microtubule plus-ends. It
Samuel J Gonzalez, Julia M Heckel, Rebecca R Goldblum, Taylor A Reid, Mark McClellan, Melissa K Gardner   +5 more
doaj   +1 more source

ECM‐Stiffness Mediated Persistent Fibroblast Activation Requires Integrin and Formin Dependent Chromatin Remodeling

Advanced Science, EarlyView.
Prolonged exposure to stiff extracellular matrix drives cancer‐associated fibroblasts into a persistently activated myofibroblast state. Two parallel pathways are identified: β1 integrin activation smoothens the nuclear lamina to reduce lamin–chromatin contacts, while the formin mDia2 regulates nuclear actin to alter chromatin organization.
Swathi Packirisamy, Oscar André, Zhimeng Fan, Pontus Nordenfelt, Vinay S Swaminathan   +4 more
wiley   +1 more source

Mutation in beta1-tubulin correlates with macrothrombocytopenia in Cavalier King Charles Spaniels.

, 2008
BACKGROUND Cavalier King Charles Spaniels (CKCS) have a high prevalence of inherited macrothrombocytopenia. The purpose of this study was to determine if a mutation in beta1-tubulin correlated with presumptive inherited macrothrombocytopenia ...
Schuller, Simone, Toivio-Kinnucan, M, Boudreaux, M K, Davis, B   +3 more
core   +1 more source

An Integrated QSAR-MD-DCCM Pipeline: A Predictive Computational Platform for the Rational Design and Dynamic Functional Validation of Dual-Target Directed Ligands

Pharmaceuticals
Background: The development of Multi-Target-Directed Ligands (MTDLs) has emerged as a significant strategy for addressing complex, overlapping pathologies such as cancer and Alzheimer’s disease (AD).
Shrikant S. Nilewar, Santosh Chobe, Prashik Dudhe, Perli Kranti Kumar, Sandesh Lodha, Akansha D. Raut, Dennys Fernández-Conde, Mohd Farhan, Ghazala Muteeb, Tushar Janardan Pawar   +9 more
doaj   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Tubulin in MT formation.

, 2013
(A) Tubulin dimer. Light grey –α-tubulin, Dark Grey – β-tubulin. C-terminal tails extend from the main tubulin body. (B) B-lattice MT with protofilament highlighted. (C) Tubulin interactions in MT formation.
Travis J. A. Craddock (318229), Khaled H. Barakat (293854), Sambasivarao Damaraju (102523), Jack A. Tuszynski (160860), Marc St. George (318231), Stuart Hameroff (318239), Holly Freedman (318234)   +6 more
core   +1 more source

Tubulin monoglutamylation is sufficient to rescue the ciliary motility defects in a Chlamydomonas polyglutamylation deficient mutant

Frontiers in Cell and Developmental Biology
IntroductionThe axonemes of eukaryotic cilia and flagella display high tubulin glutamylation heterogeneity, yet the functional significance of this variation remains elusive.
Rinka Sasaki, Toshiyuki Oda, Tomohiro Kubo   +2 more
doaj   +1 more source

Polymer Matrix‐Based 3D Culture Significantly Enhances the Differentiation and Immunomodulatory Functions of Human Adipose‐Derived Stem Cells

Advanced Science, EarlyView.
The 3D culture of human adipose‐derived stem cells (hADSCs) on a crosslinked cyclosiloxane‐based poly‐Z matrix platform enables the formation of spheroid structures enriched with extracellular matrix (ECM). These ECM‐enriched hADSC spheroids cultured on poly‐Z exhibit enhanced differentiation potential, immunomodulatory capacity, and in vivo ...
Changjin Seo, Dohyeon Kim, Junhyuk Song, Sun‐Young Kim, Youngju Son, Afia Tasnim Rahman, Sangyong Jon   +6 more
wiley   +1 more source

Tubulin acetylation and deacetylation.

, 2013
(a) Schematic representation of the acetylation and deacetylation of microtubules by αTAT and HDAC6, respectively. (b) Western blots of non-treated, acetylated, and deacetylated tubulin with anti-b-tubulin (SAP4G5, Abnova), anti-AcK40 (6–11B-1, Thermo ...
Elisabeth Fischermeier (312999), Václav Beránek (312997), Wilhelm J. Walter (312995), Stefan Diez (313000)   +3 more
core   +1 more source

3D-QSAR, molecular docking, ADMET, simulation dynamic, and retrosynthesis studies on new styrylquinolines derivatives against breast cancer

Open Chemistry
Breast cancer is the most common illness among women, accounting for 25% of all diagnoses, as stated by the American Cancer Society. Current research focuses on 43 compounds of styrylquinoline derivatives as potential inhibitors of tubulin to design a ...
EL-Mernissi Reda, Alaqarbeh Marwa, Khaldan Ayoub, Kara Mohammed, Al kamaly Omkulthom, Alnakhli Anwar M., Lakhlifi Tahar, Sbai Abdelouahid, Ajana Mohammed Aziz, Bouachrine Mohammed   +9 more
doaj   +1 more source