Results 141 to 150 of about 411,364 (358)

Tubulin‐Associated Nucleoside Diphosphokinase [PDF]

open access: bronze, 1979
M. Jacobs, Philippe Huitorel
openalex   +1 more source

Measuring and modeling polymer gradients argues that spindle microtubules regulate their own nucleation

open access: yes, 2017
Spindles are self-organized microtubule-based structures that segregate chromosomes during cell division. The mass of the spindle is controlled by the balance between microtubule turnover and nucleation. The mechanisms that control the spatial regulation
Foster, Peter J.   +5 more
core   +1 more source

Vertical Nanostructures as Novel Interfaces for Brain Research

open access: yesAdvanced Materials Interfaces, EarlyView.
This review highlights the unique features of vertical nanostructures (nanoneedles, nanostraws, nanopillars, and nanowires) for applications in brain research. Various characteristics of nanostructures, including material selection, fabrication methodology, and geometric designs, are discussed for their specific use in neurite guidance, neuron pinning,
Hao Nguyen Tran   +3 more
wiley   +1 more source

Live Quantitative Characterization for Stem Cell Biomechanics

open access: yesAdvanced Materials Interfaces, EarlyView.
These findings demonstrate an accessible technique for real‐time, high‐resolution mechanical mapping of live stem cells, without the use of specialised probes or advanced modelling techniques. This approach provides direct insight into localised cytoskeletal dynamics under chemical treatment and holds potential for broader application in understanding ...
Kaiwen Zhang   +5 more
wiley   +1 more source

3D‐Printed Unibody Microfluidic Devices for Organ‐on‐Chip Applications

open access: yesAdvanced Materials Technologies, EarlyView.
A practical approach is demonstrated to 3D printing unibody microfluidic Organ‐on‐Chip (OoC) devices using commercial resins and desktop DLP printers. The demonstrated functional devices support 2D monolayers, 3D spheroids, and barrier tissues. With optimised design and post‐processing techniques, leak‐free, biocompatible microchannels and membranes ...
Louis Jun Ye Ong   +8 more
wiley   +1 more source

3-aryl-4-(3,4,5-trimethoxyphenyl)pyridines inhibit tubulin polymerisation and act as anticancer agents

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry
A series of cis-restricted 3-aryl-4-(3,4,5-trimethoxyphenyl)pyridines as novel tubulin polymerisation inhibitors was designed based on molecular docking.
Chao Wang   +6 more
doaj   +1 more source

In vitro reactivation of spindle elongation in fission yeast nuc2 mutant cells. [PDF]

open access: yes, 1990
To investigate the mechanisms of spindle elongation and chromosome separation in the fission yeast Schizosaccharomyces pombe, we have developed an in vitro assay using a temperature-sensitive mutant strain, nuc2.
Cande, WZ   +3 more
core  

ST6GAL1‐Mediated Sialylation Stabilizes PD‐L1 and Drives Immunosuppressive Tumor Microenvironment in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
ST6GAL1 plays a critical role in tumor progression and immune regulation in colorectal cancer (CRC). Its depletion significantly suppresses the malignant phenotype of CRC cells and enhances the efficacy of anti‐PD‐L1 therapy. High ST6GAL1 expression promotes an immune‐activated tumor microenvironment (TME), characterized by increased infiltration of ...
Ximo Xu   +15 more
wiley   +1 more source

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