Results 181 to 190 of about 411,364 (358)

Draper‐ATG3 Interaction Positively Regulates Autophagy to Mediate Silk Gland Degradation in Bombyx mori

Advanced Science, EarlyView.
Draper is evolutionarily conserved across most insect species. Loss of Draper inhibits autophagy activation, delaying middle silk gland degradation in the silkworm during metamorphosis. Draper interacts with autophagy ‐ related protein 3 (ATG3) to orchestrate autophagosome formation—a process essential for silk gland degradation during the larval‐pupal
Shiyu Zou, Yuhan Luo, Yue Jin, Wenhui Jing, Yuxin Huang, Yanting Liang, Yinghui Li, Zhihua Hao, Yusong Xu, Huabing Wang   +9 more
wiley   +1 more source

Addition of colchicine-tubulin complex to microtubule ends: The mechanism of substoichiometric colchicine poisoning

, 1977
Robert L. Margolis, Leslie Wilson
openalex   +1 more source

Glabridin‐Gold(I) Complex as a Novel Immunomodulatory Agent Targeting TrxR and MAPK Pathways for Synergistic Enhancement of Antitumor Immunity

Advanced Science, EarlyView.
Complex 6d could promote tumor immunogenicity by targeting thioredoxin reductase (TrxR) and remodel immunosuppressive microenvironment by the mitogen‐activated protein kinase (MAPK) pathway inhibition simultaneously. This study provides a novel approach to develop metal immunomodulatory agents by designing gold complexes incorporating natural products,
Zhaoran Wang, Meiyu Wang, Qiong Chen, Mengshi Wang, Fuwei Li, Lin Lv, Zhenfan Wen, Zhongren Xu, Yixia Yang, Chunyang Bi, Wukun Liu   +10 more
wiley   +1 more source

Norepinephrine Induces Sertoli Cell Ferroptosis via Receptors Desensitization Causing Stress‐Related Male Reproductive Dysfunction

Advanced Science, EarlyView.
Psychological stress activates the sympathetic–adrenal axis, elevating norepinephrine (NE) and suppressing reproductive hormones, thereby impairing male reproduction. Excess NE overactivates and desensitizes β‐adrenergic receptors (β‐ARs), triggering Sertoli cell ferroptosis and disrupting spermatogenesis.
Lingyu Zhang, Shanfeng Gao, Xiaofan Xiong, Xin Liu, Rufeng Li, Xia Wang, Lin Han, Xuan Xiao, Xiaofei Wang, Wen Li, Yongxia Chang, Yuefeng Du, Juan Yang   +12 more
wiley   +1 more source

Immunofluorescence of the tubulin system in cellular slime moulds [PDF]

, 1979
Eberhard Unger, Salvatore Rubino, Ted Weinert, Piero Cappuccinelli   +3 more
openalex   +1 more source

Deoxynivalenol Exposure Leads to Abnormal Renal Tubular Autophagy Flow

Advanced Science, EarlyView.
DON exposure disrupts the initiation of renal autophagy by inhibiting the formation of autophagosomes, thereby impairing mitochondrial degradation. Damaged mitochondria increase oxidative stress, reduce ferroptosis resistance, and cause lysosomal Fe2⁺ accumulation, further disrupting autophagy.
Hao Chen, Xintong Zhou, Jun Ma
wiley   +1 more source

Analysis of two screens reveals a correlation between antiamoebic and anti-tubulin activities of phenothiazine and triphenylethylene derivatives. [PDF]

RSC Med Chem
Mediannikov O, Tsvetkov PO.
europepmc   +1 more source

Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy

Advanced Science, EarlyView.
MED27 is one of the 26 subunits in the human Mediator complex (MED). Neurodevelopmental disorder‐causing MED27 genetic variants induce instability of MED, leading to disrupted DNA occupancy, altered chromatin interaction, and subsequent transcriptional dysregulation of critical downstream genes, including master regulatory transcription factors ...
Nuermila Yiliyaer, Xiaocheng Li, Tianyu Guo, Haiying Zhou, Lihai Gong, Luowei Yuan, Yang Fu, Yulong Qiao, Ying Lam Lui, Nuo Chen, Pengfei Lin, Hoi Hung Cheung, Ho Ko, Linyan Meng, Xiao Chen, Yong Lei, Kin Ming Kwan, Huating Wang, Shen Gu   +18 more
wiley   +1 more source

Structure based drug design and machine learning approaches for identifying natural inhibitors against the human αβIII tubulin isotype. [PDF]

Sci Rep
Patil PA, Kumbhar BV.
europepmc   +1 more source

PSMD14‐Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression

Advanced Science, EarlyView.
This study investigates the expression and functional role of the deubiquitinase PSMD14 in PC, with a focus on the mechanism by which it promotes lactate accumulation–induced histone lactylation, thereby driving aberrant lipid metabolism. These findings establish that dual targeting of PSMD14 and the glycolysis–lactylation signaling axis may represent ...
Ri‐Shang Lu, Li‐Kun Ren, Xiao‐Bin Fei, Song‐Bai Liu, Yong‐Jia Gao, Jun‐Yi Hou, Chi Wang, Peng Liu, Chang‐Hao Zhu, Xing Wang, Yao‐Zhen Pan   +10 more
wiley   +1 more source