Results 171 to 180 of about 289,598 (269)

A coherent structural picture of the interaction of Tau with tubulin provides a link to its aggregation. [PDF]

J Biol Chem
Gigant B, Ammar Khodja L, Campanacci V, Lippens G.   +3 more
europepmc   +1 more source

A FAP‐Targeted SMDC Platform Enables Synergistic Radionuclide–Chemotherapy with PET‐Guided Evaluation

Advanced Science, EarlyView.
A fibroblast activation protein (FAP)‐targeted small molecule–drug conjugate (SMDC) platform is developed to integrate PET imaging with synergistic radionuclide–chemotherapy. Linker chemistry governs stability, exposure, and tolerability, with the VC linker providing superior in vivo performance.
Ruitao Yang, Hongxin Li, Zexin Xu, Baocheng Chen, Ningjie Li, Yuhua Zhong, Kongzhen Hu   +6 more
wiley   +1 more source

MCAK/Kif2C centromeric activity level tunes K-fiber turnover through distinct pathways. [PDF]

iScience
Wagenbach M, Vicente JJ, Wordeman L.
europepmc   +1 more source

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

βIII-tubulin can act as a brake on extrinsic apoptosis in pancreatic cancer. [PDF]

Cell Death Dis
Sharbeen G, Kokkinos J, Schulstad G, Pandzic E, Youkhana J, Ma Z, Ignacio RMC, Raina AS, Chiang S, Boyer C, Haghighi KS, Gunawarman M, Goldstein D, Gebski V, Pajic M, Davis ME, Arkell OSM, Kopecky C, Gonzales-Aloy E, Ishak A, Erkan M, Morton JP, Kavallaris M, Gunning PW, Hardeman EC, Johns A, Gill AJ, Whan RM, Mawson A, Pitiyarachchi O, Australian Pancreatic Cancer Genome Initiative, McCarroll JA, Phillips PA.   +32 more
europepmc   +1 more source

Microbial Odorant Detection Guides Drosophila Parasitoids Seeking Hosts in Fermenting Fruits

Advanced Science, EarlyView.
Yeast microbes in fermenting fruits attract both host flies and their parasitoid wasps. Female Leptopilina boulardi detect yeast‐emitted ethyl esters via two olfactory receptors, LbouOR167 and LbouOR136. A conserved residue, Leu159, is critical for binding these compounds, enabling female wasps to locate host‐rich habitats.
Yueqi Lu, Lan Pang, Wenqi Shi, Ting Feng, Zhi Dong, Yifeng Sheng, Sicong Zhou, Longtao Yu, Hao Guo, Ying Wang, Jiani Chen, Jianhua Huang   +11 more
wiley   +1 more source

Tubulin polyglutamylases TTLL4C and TTLL6B are essential for maintaining cytoskeletal integrity in <i>Trypanosoma brucei</i>. [PDF]

mSphere
Brehm L, Röder M, Lamer S, Thein M, Schlosser A, Unverzagt C, Ersfeld K.   +6 more
europepmc   +1 more source

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

PM534, a Novel Colchicine Site Tubulin Inhibitor with Broad-Spectrum and Resistance-Overcoming Antitumor Activity. [PDF]

Mol Cancer Ther
Aviles P, Ribeiro ML, Guillén MJ, Martinez-Diez M, Muñoz-Alonso MJ, Santamaria-Nuñez G, Torralba D, Alamo P, Gallardo A, Oliva MA, Mangues R, Diaz JF, Cuevas C.   +12 more
europepmc   +1 more source

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source