Results 221 to 230 of about 407,673 (329)

DDAH1 Promotes Cisplatin Chemoresistance in Patients with Locally Advanced Nasopharyngeal Carcinoma via the EGFR‐JAK2‐STAT3 Pathway

Advanced Science, EarlyView.
This study identifies a novel mechanism of nasopharyngeal carcinoma (NPC) cisplatin chemoresistance that DDAH1 expression is associated with cisplatin resistance in NPC cells primarily through the enhancement of the phosphoinositide Janus kinase 2 (JAK2)‐signal transducer and activator of transcription 3 (STAT3) pathway.
Jin‐Hao Yang, Li Yuan, Qiu‐Yan Chen, Kai‐Qi Lan, Liang‐Ji Li, Yu‐Chen Li, Xiao‐Yun Li, Xue‐Song Sun, Lin‐Quan Tang, Sai‐Lan Liu, Hai‐Qiang Mai   +10 more
wiley   +1 more source

Editorial: The isotypes of α, β and γ tubulin: From evolutionary origins to roles in metazoan development and ligand binding differences

Frontiers in Cell and Developmental Biology, 2023
Jeffrey Moore, Richard Luduena, Jack A. Tuszynski, Jack A. Tuszynski, Jack A. Tuszynski   +4 more
doaj   +1 more source

Polyglutamylation of microtubules drives neuronal remodeling. [PDF]

Nat Commun
Gavoci A, Zhiti A, Rusková M, Magiera MM, Wang M, Ziegler KA, Hausrat TJ, Ugwuja AI, Chakraborty S, Engelhardt S, Kneussel M, Balastik M, Janke C, Misgeld T, Brill MS.   +14 more
europepmc   +1 more source

Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
These study underscores the pivotal role of neutrophil‐derived myeloid‐related protein 14 (MRP14) in the pathophysiology of acute ischemic stroke (AIS). MRP14 not only disrupts mitochondrial function, thereby inhibiting microglial phagocytosis of neutrophils, but also activates microglial pyroptosis, exacerbating neuroinflammation following AIS ...
Huijuan Jin, Zhifang Li, Senwei Tan, Qinghui Xiao, Qingcan Li, Jiao Ye, Yifan Zhou, Yan Wan, Qiang Liu, Bijoy K Menon, Bo Hu   +10 more
wiley   +1 more source

Cell state-specific cytoplasmic density controls spindle architecture and scaling. [PDF]

Nat Cell Biol
Kletter T, Muñoz O, Reusch S, Biswas A, Halavatyi A, Neumann B, Kuropka B, Zaburdaev V, Reber S.   +8 more
europepmc   +1 more source

Interaction of viomycin and aminoglycoside antibiotics with tubulin and microtubules.

, 1978
Tetsu Akiyama, Kenji Tanaka, Nobuo Tanaka, Yoshiaki Nonomura   +3 more
openalex   +2 more sources

Generation of antisera that discriminate among mammalian alpha-tubulins: introduction of specialized isotypes into cultured cells results in their coassembly without disruption of normal microtubule function. [PDF]

, 1988
Wei Gu, Sally A. Lewis, Nicholas J. Cowan   +2 more
openalex   +1 more source

Multi‐Region Brain Organoids Integrating Cerebral, Mid‐Hindbrain, and Endothelial Systems

Advanced Science, EarlyView.
Multi‐Region Brain Organoids combine cerebral, mid/hindbrain, and endothelial components into an advanced 3D model capturing 80% of fetal brain cellular diversity. This platform reveals essential endothelial‐neural signaling networks that maintain region‐specific intermediate progenitors during hindbrain development.
Anannya Kshirsagar, Hayk Mnatsakanyan, Sai Kulkarni, John Guo, Kai Cheng, Luke Daniel Ofria, Oce Bohra, Ram Sagar, Vasiliki Mahairaki, Christian E Badr, Annie Kathuria   +10 more
wiley   +1 more source

Molecular Guardians of Oocyte Maturation: A Systematic Review on TUBB8, KIF11, and CKAP5 in IVF Outcomes. [PDF]

Int J Mol Sci
Voros C, Sapantzoglou I, Athanasiou D, Varthaliti A, Mavrogianni D, Bananis K, Athanasiou A, Athanasiou A, Papadimas G, Gkirgkinoudis A, Papapanagiotou I, Migklis K, Vaitsis D, Koulakmanidis AM, Mazis Kourakos D, Ivanidou S, Daskalaki MA, Theodora M, Antsaklis P, Loutradis D, Daskalakis G.   +20 more
europepmc   +1 more source

Microtubules and protein secretion in rat lacrimal glands. Inhibitory effect of the tubulin . colchicine complex isolated from lacrimal glands upon brain tubulin polymerization. Identification of the complex by gel electrophoresis.

, 1979
Anne‐Marie Chambaut‐Guérin, P. Müller, B. Rossignol   +2 more
openalex   +1 more source