Results 231 to 240 of about 420,141 (304)

Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361)

, 2018
Michael Smolinski, Yahao Bu, James L. Clements, Irwin H. Gelman, Taher Hegab, David L. Cutler, Jane Fang, Gerald J. Fetterly, Rudolf Kwan, Allen Barnett, Johnson Y. N. Lau, David Hangauer   +11 more
openalex   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

KDM4A serves as an α-tubulin demethylase regulating microtubule polymerization and cell mitosis. [PDF]

Sci Adv
Cao S, Wang S, Xie X, Tan X, Hu X, Shao F, Liu Y, Zhang X, Cheng H, Diao L, Bao L.   +10 more
europepmc   +1 more source

ε-tubulin and δ-tubulin in Tetrahymena thermophila Are Essential Components of Basal Bodies

, 2012
Ian K. Ross
openalex   +1 more source

PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice

Advanced Science, EarlyView.
Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han, Qin Yuan, Zhu Wu, Yaohui Fang, Hong Qian, Jiale Zhu, Yuchen Zhang, Ke Deng, Liangliang Su, Haibo Xu, Haotian Shu, Yiming Gong, Qiaoqiao Xu, Guizhen Du, Di Wu, Yun Fan, Chuncheng Lu   +16 more
wiley   +1 more source

Notch signaling stabilizes lengths of motile cilia in multiciliated cells in the lung. [PDF]

Life Sci Alliance
Joy N, Deshpande A, Lingamallu SM, Prabantu VM, Naveenkumar CN, Bharathkumar K, Bhat S, Alvarado-Martinez Z, Livraghi-Butrico A, Hagood JS, Boucher RC, Lafkas D, Byrd KM, Narayanan S, Shandil RK, Guha A.   +15 more
europepmc   +1 more source

Nucleotide sequence and expression of two beta-tubulin genes in Stylonychia lemnae [PDF]

, 1987
Conzelmann, Karl-Klaus, Helftenbein, E.
core  

COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 17)TESTICULAR TOXICITY OF E7010, A SULFONAMIDE TUBULIN POLYMERIZATION INHIBITOR

, 2000
Kazuhiro Hayakawa, Toshifumi Tashiro, Kunio Sato, Tomiharu Katsurayama, Toshio Imai, Satoru Hosokawa, Fumio Sagami   +6 more
openalex   +2 more sources

Parallel Genome‐Wide CRISPR Screens Reveal SORL1 and ZFYVE19 as Sequential Host Determinants of Salmonella Infection

Advanced Science, EarlyView.
To distinguish how Salmonella invades cells vs how it survives long‐term, a parallel CRISPR screening platform is developed. This approach reveals the host proteins that the bacterium exploits at different stages of infection. The study identifies SORL1 as a novel host factor for invasion and demonstrates that blocking it with an antibody effectively ...
Sehee Yun, Seoyeon Kim, Seonggyu Kim, Minsoo Noh, Dae‐Kyum Kim, Eun‐Jin Lee, Hunsang Lee   +6 more
wiley   +1 more source

Real-time FRET assay for monitoring detyrosination by TMCP1 and VASH2. [PDF]

Protein Sci
Simon M, Espeut J, Juge F, Amblard M, Rogowski K, Vezenkov L.   +5 more
europepmc   +1 more source