Results 261 to 270 of about 407,673 (329)

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

Advanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang, Fang Li, Jiao Liu, Shu‐Ang Li, Dan‐Hua Liu, Zhuanbin Wu, Pei‐Pei Liu, Wenju Liu, Bin Zhou, Cizhong Jiang, Haibing Zhang, Ying Yu, Jian‐Sheng Kang   +12 more
wiley   +1 more source

Microtubule dynamics are defined by conformations and stability of clustered protofilaments. [PDF]

Proc Natl Acad Sci U S A
Kalutskii M, Grubmüller H, Volkov VA, Igaev M.   +3 more
europepmc   +1 more source

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li, Wei Li, Yan Leng, Heng Xu, Zhongyuan Xia, Yao Wang   +5 more
wiley   +1 more source

Synthesis and multi-target antiproliferative evaluation of novel 1,2,4-triazole-3-thione analogues against breast cancer: <i>in silico</i> and <i>in vitro</i> mechanistic insights. [PDF]

RSC Adv
Almasmoum HA, Almaimani G, Almaimani RA, Babakr AT, Alsunbul M, Alshwyeh HA, Zayed ES, Aziz Ibrahim IA, Saied EM.   +8 more
europepmc   +1 more source

Autoregulation of tubulin synthesis in hepatocytes and fibroblasts.

, 1985
Joan M. Caron, Albert L. Jones, Marc W. Kirschner   +2 more
openalex   +1 more source

Inhibition of FOXM1 Synergizes with BH3 Mimetics Venetoclax and Sonrotoclax in Killing Multiple Myeloma Cells through Repressing MYC Pathway

Advanced Science, EarlyView.
Relapsed and refractory multiple myeloma remains a major clinical challenge. This study shows that FOXM1 contributes to resistance against BH3 mimetics in multiple myeloma cells. The FOXM1 inhibitor NB73 enhances the effectiveness of BH3 mimetics by reducing FOXM1 expression and suppressing the MYC pathway.
Zhi Wen, Yidan Wang, Kathryn C. Fox, Adam M. Bissonnette, Luke F. Moat, Terrie E. Kitchner, Kelsey Springstroh, Sung Hoon Kim, Dagna S. Sheerar, Patcharon Tanawattanacharoen, Chady A. Leon, Seth O. Fagbemi, John A. Katzenellenbogen, Scott J. Hebbring, Benita S. Katzenellenbogen, Siegfried Janz, Adedayo A. Onitilo   +16 more
wiley   +1 more source

Design, synthesis, <i>in silico</i> and <i>in vitro</i> evaluation of pyrrole-indole hybrids as dual tubulin and aromatase inhibitors with potent anticancer activities. [PDF]

RSC Adv
Saruengkhanphasit R, Chatwichien J, Ngiwsara L, Lirdprapamongkol K, Niwetmarin W, Eurtivong C, Kittakoop P, Svasti J, Ruchirawat S.   +8 more
europepmc   +1 more source

Electronic Nanomaterials for Plants: A Review on Current Advances and Future Prospects

Advanced Electronic Materials, EarlyView.
Global food security faces mounting challenges from climate change and rapid population growth. This review highlights the pivotal role of electronic nanomaterials–including metals, metal oxides, and carbon‐based structures–in enhancing plant photosynthesis, nutrient uptake, and stress resilience. Furthermore, it explores how emerging platforms such as
Ciro Allará, Giuseppe Ciccone, Manuela Ciocca, Sahira Vasquez, Pietro Ibba, Mauro Maver, Tanja Mimmo, Paolo Lugli, Luisa Petti   +8 more
wiley   +1 more source

A General Strategy to Fine‐Tune Group 14 Rhodamines for Ultrahigh Signal‐to‐Noise Ratio Labeling In Vivo by Nano‐Aggregation

Aggregate, EarlyView.
Group 14 rhodamines are one of the most widely explored fluorogenic probes with high signal‐to‐noise ratio (SNR). We have boosted the SNR of group 14 rhodamines by nano‐aggregation via a novel strategy by manipulating their dynamic physical and chemical states for the first time. The ultrahigh SNR fluorescence imaging offers a fundamental understanding
Ning Wang, Ting Wang, Mengting Fan, Chen Li, Yue Tian, Xiaoyan Cui   +5 more
wiley   +1 more source

Focal adhesion-related non-ciliary functions of CEP290. [PDF]

PLoS One
Matsuo K, Nakajima Y, Shigeta M, Kobayashi D, Sakaki S, Inoue S, Takeshita N, Ueyama A, Nishikawa K, Saba R, Yamasaki H, Yamada K, Yokoyama T, Yashiro K.   +13 more
europepmc   +1 more source