Results 271 to 280 of about 420,141 (304)

Fe‐S Protein FDX1 Triggers Tumor‐Intrinsic Innate Immunity via Mitochondrial Nucleic Acids Release to Orchestrate Ferroptosis in CCRCC

Advanced Science, EarlyView.
Restoration of the mitochondrial Fe–S protein FDX1 suppresses clear cell renal cell carcinoma by coupling ferroptosis with tumor‐intrinsic innate immune activation. FDX1 induces mitochondrial dysfunction and mtDNA/mt‐dsRNA release, activating cGAS–STING and RIG‐I/MDA5–MAVS signaling to elicit type I interferon responses, thereby promoting antigen ...
Xing Huang, Shaoqing Yu, Wenjie Wei, Wen Tao, Tianwei Cai, Lequan Wen, Jiali Ye, Chi Zhang, Huayi Feng, Senming Cao, Baojun Wang, Xin Ma, Yan Huang, Xu Zhang   +13 more
wiley   +1 more source

STK405759 targets microtubules, modulates STAT1, and enhances ruxolitinib efficacy in myeloproliferative neoplasms. [PDF]

Am J Cancer Res
Rozic G, Makaros Y, Shapira-Netanelov I, Kardash T, Maizels Y, Koman I, Leiba M, Duek A.   +7 more
europepmc   +1 more source

Synthesis of Bispecific Conjugates by ADP‐Ribosyl Cyclases

Advanced Science, EarlyView.
Genetic fusion of a CD38 enzymatic domain to antibody scaffolds allows site‐specific conjugation of small‐molecule ligands. Using this approach, a PSMA ligand DUPA is conjugated with an anti‐human CD3 Fab antibody. The resulting bispecific anti‐CD3‐DUPA conjugate facilitates recruitment and activation of cytotoxic T cells against PSMA‐expressing ...
Sunny H. Kim, Arshad J. Ansari, Lei Zhang, Guoyun Kao, Thuc Oanh Hoang, Zeyu Zhang, Srinivasarao Singireddi, Benjamin B. Katz, Yong Zhang   +8 more
wiley   +1 more source

The luminal ring protein C2CD3 acts as a radial in-to-out organizer of the distal centriole and appendages. [PDF]

PLoS Biol
Bertiaux E, Louvel V, McCafferty CL, van den Hoek H, Batman U, Mukherjee S, Bournonville L, Mercey O, Méan I, Righetto RD, Müller A, Van der Stappen P, Buss G, Daraspe J, Genoud C, Stearns T, Engel BD, Hamel V, Guichard P.   +18 more
europepmc   +1 more source

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

How augmin establishes the angle of the microtubule branch site. [PDF]

Nat Commun
Travis SM, Kraus J, McManus CT, Golden K, Zhang R, Petry S.   +5 more
europepmc   +1 more source

Analysis of two screens reveals a correlation between antiamoebic and anti-tubulin activities of phenothiazine and triphenylethylene derivatives. [PDF]

RSC Med Chem
Mediannikov O, Tsvetkov PO.
europepmc   +1 more source

The E3 Ligase UBR5/Hyd Ensures Meiotic Fidelity Through Catalysis-Independent Regulation of β2-Tubulin in <i>Drosophila</i>. [PDF]

Genes (Basel)
Zhou L, Lin L, Zhang Y, Shen C, Qi Y, Lin X.   +5 more
europepmc   +1 more source

Structure based drug design and machine learning approaches for identifying natural inhibitors against the human αβIII tubulin isotype. [PDF]

Sci Rep
Patil PA, Kumbhar BV.
europepmc   +1 more source