Blood α‐Synuclein Separates Parkinson's Disease from Dementia with Lewy Bodies
Objective Aggregation of misfolded α‐synuclein (aSyn) within the brain is the pathologic hallmark of Lewy body diseases (LBDs), including Parkinson's disease (PD), and dementia with Lewy bodies (DLB) disease. Although evidence exists for aSyn “strains,” conformations with distinct biological properties, biomarkers for PD versus DLB are lacking.
George T. Kannarkat+17 more
wiley +1 more source
Advances on Albumin‐Based Carriers for Anticancer Drug Delivery
This study systematically classifies the drug delivery modes of albumin by examining the characteristics of its surface‐active groups and internal binding sites. It provides an in‐depth analysis of various drug delivery strategies and their corresponding targeting mechanisms.
Ruoli Zhou+4 more
wiley +1 more source
This study innovatively develops a multifunctional, multienzyme‐active nanoplatform (FeCP@PDA‐GOx), aimed at overcoming the limitations of traditional cancer therapies and achieving precise, efficient, and long‐lasting melanoma treatment. By integrating starvation therapy, CDT, mPTT, and immunotherapy, FeCP@PDA‐GOx generates a multidimensional ...
Qihang Ding+6 more
wiley +2 more sources
Schematic illustration showing the design of the developed invitro mechano stimulator (IMS) and the electrospun nanofiber‐based piezoelectric and conductive nerve conduit (PCNC) that can self‐generate electrical stimulations analogous to neural tissues. IMS provided vital electrical cues for the neural cells to attach, align and proliferate on the PCNC
Afeesh Rajan Unnithan+5 more
wiley +1 more source
A highly stereoselective, dynamic reductive kinetic resolution (DYRKR) entry into myriad Taxotere‐like side chains with Clostridium acetobutylicum alcohol dehydrogenase (CaADH) enzyme is reported. Follow‐on cross couplings expand the structural diversity of the library (36 total examples).
Gaurav P. Kudalkar+15 more
wiley +2 more sources
Nanostructured Biomaterial‐Based Approaches to Support Induced Pluripotent Stem Cell Differentiation
Induced pluripotent stem cells (iPSCs), reprogrammed from adult somatic cells, represent an innovative approach for regenerative medicine and biomedical applications. This review highlights the importance of nanostructured biomaterials, utilized as delivery systems or scaffolds, in supporting iPSC differentiation and fate through structural and ...
Beatriz A. B. R. Passos+2 more
wiley +1 more source
African swine fever virus infection of porcine peripheral blood monocyte-derived macrophages induces the formation of tunneling nanotube-connected large vesicle-like cell segments: a potential mechanism for intercellular ASFV trafficking. [PDF]
Droesbeke B+4 more
europepmc +1 more source
AI-enabled drug prediction and gene network analysis reveal therapeutic use of vorinostat for Rett Syndrome in preclinical models. [PDF]
Novak R+17 more
europepmc +1 more source
Mutations in NEK1 cause ciliary dysfunction as a novel pathogenic mechanism in amyotrophic lateral sclerosis. [PDF]
Noh MY+10 more
europepmc +1 more source
Synthesis, cytotoxic activity, molecular docking, molecular dynamics simulations, and ADMET studies of novel spiropyrazoline oxindoles based on domino Knoevenagel-Michael cyclization as potent non-toxic anticancer agents targeting β-tubulin and EGFR, with anti-MRSA activity. [PDF]
Seliem IA.
europepmc +1 more source