Results 291 to 300 of about 407,673 (329)

Unsaturated Phosphine Oxides for Modular Antibody Rebridging and Single Reagent Peptide‐Cyclisation‐Bioconjugation

Angewandte Chemie International Edition, Accepted Article.
Achieving modular, selective and homogeneous protein modifications is of utmost importance for the design of next generation biopharmaceuticals; especially in the context of antibody‐drug conjugates (ADCs). Here, we introduce unsaturated phosphine oxides as versatile triple‐reactive reagents, allowing orthogonal chemoselective bioconjugation schemes ...
Christian E. Stieger, Alastair McMillan, Mark A. R. de Geus, Jan Vincent Arafiles, Luise Franz, Christian Hackenberger   +5 more
wiley   +1 more source

Exogenous H₂S reduces oxidative stress induced by lipid mixture in HepG2 cells through USP22/SIRT1 axis. [PDF]

Sci Rep
Cui X, Li C, He S, Li Y.
europepmc   +1 more source

Synthesis of Epoxyoxirenes: Phytotoxic Activity and Enzymatic Target Identification. [PDF]

Plants (Basel)
de Faria KCF, Alvarenga ES, Oliveira DF, Baia VC, Isenmann AF.   +4 more
europepmc   +1 more source

Establishment of Interspecies Somatic Cell Nuclear Transfer and Transgene‐Free Inducible Pluripotent Stem Cells for Versatile Conservation of the Germplasm Resource of Wild Boar

Animal Research and One Health, EarlyView.
Conserving genetic material and even increasing genetic diversity is critical. To conduct the conservation of wild boar germplasm resources, we have successfully obtained healthy cloned wild boars for the first time using interspecies somatic cell nuclear transfer and established transgene‐free iPSCs that can be used to conduct iterative rounds of gene
Chen Gao, Xinyi Zhou, Shigang Gu, Jianbo Li, Jing Wang, Yurong Zhang, Wenxuan Zhao, Xinhua Wei, Liting Lu, Quanmin Zhao, Yongye Huang, Dawei Yu   +11 more
wiley   +1 more source

Microtubule dynamics is a therapeutic vulnerability in VHL-deficient renal cell carcinoma. [PDF]

Int J Biol Sci
Pu Y, Wang Z, Tao S, Yang EJ, Wu S, Ren G, Chen LJ, Zhang X, Tan K, Dang Y, Shim JS.   +10 more
europepmc   +1 more source

Ubiquitin C‐Terminal Hydrolase L1 (UCHL1), Beyond Hydrolysis

BioEssays, EarlyView.
UCHL1 is a neuron‐enriched component of the ubiquitin‐proteasome system. This review debates the biological relevance of its biochemical roles: limited DUB activity, potential ligase function, and mono‐ubiquitin stabilization. We emphasize the need to clarify the mechanisms and identify natural substrates for each function to understand their role in ...
Anwar Bdarneh, Inbal Maniv, Michael H. Glickman   +2 more
wiley   +1 more source

Cytoplasmic connexin43-microtubule interactions promote glioblastoma stem-like cell maintenance and tumorigenicity. [PDF]

Cell Death Dis
Smyth JW, Guo S, Chaunsali L, O'Rourke L, Dahlka J, Deaver S, Lunski M, Nurmemmedov E, Sontheimer H, Sheng Z, Gourdie RG, Lamouille S.   +11 more
europepmc   +1 more source

Hepatic microtubule destabilization facilitates liver fibrosis in the mouse model of Wilson disease. [PDF]

J Mol Med (Berl)
Dev S, Dong Y, Hamilton JP.
europepmc   +1 more source

A Novel HDAC6 Inhibitor Enhances the Efficacy of Paclitaxel Against Ovarian Cancer Cells. [PDF]

Molecules
Chi AJ, Hsu JL, Xiao YX, Chern JW, Guh JH, Yu CW, Hsu LC.   +6 more
europepmc   +1 more source

An Indole Dearomatization Strategy for the Synthesis of Pseudo-Natural Products. [PDF]

Chembiochem
Hoock JGF, Burhop A, Greiner LC, Schölermann B, Da Cruz Lopes Guita C, Liu J, Bag S, Pahl A, Sievers S, Scheel R, Strohmann C, Ziegler S, Grigalunas M, Waldmann H.   +13 more
europepmc   +1 more source