Results 71 to 80 of about 1,423 (197)

Central nervous system tumefactive demyelinating lesions: Risk factors of relapse and follow-up observations

Frontiers in Immunology, 2022
ObjectiveTo track the clinical outcomes in patients who initially presented with tumefactive demyelinating lesions (TDLs), we summarized the clinical characteristics of various etiologies, and identified possible relapse risk factors for TDLs ...
Xinnan Li, Xiuling Miao, Yaming Wang, Junzhao Sun, Haifeng Gao, Jing Han, Yuxin Li, Qingjun Wang, Chenjing Sun, Jianguo Liu   +9 more
doaj   +1 more source

Biopsy Proven Tumefactive Multiple Sclerosis with Concomitant Glioma: Case Report and Review of the Literature

Frontiers in Neurology, 2015
We report a case of pathologically confirmed tumefactive multiple sclerosis (MS) followed shortly thereafter by the diagnosis of an oligoastrocytoma.
Esteban eGolombievski, Matthew eMcCoyd, john elee, Michael J Schneck   +3 more
doaj   +1 more source

High clinical heterogeneity in a Chinese pedigree of retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S)

Orphanet Journal of Rare Diseases, 2021
Background Being a newly defined disease, RVCL-S is underrecognized by clinicians globally. It is an autosomal dominantly inherited small vessel disease caused by the heterozygous C-terminal frameshift mutation in TREX1 gene.
Nina Xie, Qiying Sun, Jinxia Yang, Yangjie Zhou, Hongwei Xu, Lin Zhou, Yafang Zhou   +6 more
doaj   +1 more source

Tumefactive multiple sclerosis requiring emergent biopsy and histological investigation to confirm the diagnosis: a case report [PDF]

, 2012
Introduction Tumefactive multiple sclerosis is a demyelinating disease that demonstrates tumor-like features on magnetic resonance imaging. Although diagnostic challenges without biopsy have been tried by employing radiological studies and cerebrospinal ...
Hoya, Katsumi, Ishida, Yasuo, Matsuno, Akira, Murakami, Mineko, Nakaguchi, Hiroshi, Yamada, Shoko Merrit, Yamada, So, Yamazaki, Kazuto   +7 more
core   +3 more sources

Multifaceted Biomarkers Suggest a Similar Profile of CNS Pathology in Relapsing and Progressive MS

European Journal of Neurology, Volume 32, Issue 2, February 2025.
ABSTRACT Background Relapsing–remitting (RR) and primary progressive (PP) multiple sclerosis (MS) have distinct clinical courses, but underlying pathophysiological differences remain unclear. We compared pathological components between RRMS, PPMS, and other inflammatory and neurodegenerative disorders, leveraging soluble biomarkers and post‐mortem ...
Katelijn M. Blok, Romy A. M. Klein Kranenbarg, Kirtana Ananth, Hendrik J. Engelenburg, Aletta van den Bosch, Lucia A. A. Giannini, Janet de Beukelaar, Harro Seelaar, Inge Huitinga, Ari Green, Beatrijs Wokke, Ahmed Abdelhak, Joost Smolders   +12 more
wiley   +1 more source

Frequency of cerebrovascular accidents and brain abscess in childrens with tetralogy of fallot Dr. [PDF]

, 2015
OBJECTIVE: To determine the frequency of cerebrovascular accidents and brain abscess in children of Tetralogy of Fallot presented with neurological manifestations. PATIENTS AND METHODS: It was a cross-sectional descriptive observational study done at the
Aftab, Sommayya, Sultan, Tipu, Usman, Amir   +2 more
core   +1 more source

Tumefactive Demyelinating Lesions and Pregnancy

Neurology India, 2019
Until now, only one gestational tumefactive demyelinating lesion (TDL) has been described. Here we report two TDL cases occurring during and after the pregnancy. A 26-year-old 6-week pregnant woman developed a 3-cm left frontotemporoparietal subcortical TDL with inhomogeneous partial enhancement.
Plantone, Domenico, Piantadosi, Carlo, Ruggieri, Serena, Anelli, Vincenzo, Koudriavtseva, Tatiana   +4 more
openaire   +3 more sources

Relapsing Tumefactive Demyelination: A Case Report [PDF]

Acta Medica Academica, 2018
<p><strong>Objective. </strong>We present a case of relapsing tumefactive demyelination in a young female patient, that posed a real diagnostic challenge, with a heterogeneous clinical picture, atypical for multiple sclerosis (MS) presentation, and neuroradiological manifestations with a high suspicion of neoplastic diseases.</p>
Ibrahim, Omerhodžić, Almir, Džurlić, Dino, Lisica, Nevena, Mahmutbegović, Maida, Nikšić, Nurija, Bilalović, Enra, Suljić   +6 more
openaire   +2 more sources

Neurological complications of immune checkpoint inhibitors: what happens when you \u27take the brakes off\u27 the immune system. [PDF]

, 2018
Patients with advanced malignancies treated with immune checkpoint inhibitors are at increased risk for developing immune-related neurological complications.
Dalakas, Marinos
core   +1 more source

Chronic active lesions preferentially localize in watershed territories in multiple sclerosis

Annals of Clinical and Translational Neurology, Volume 11, Issue 11, Page 2912-2922, November 2024.
Abstract Objective Paramagnetic rim lesions (PRLs) are a biomarker of chronic active lesions (CALs), and an important driver of neurological disability in multiple sclerosis (MS). The reason subtending some acute lesions evolvement into CALs is not known. Here we ask whether a relatively lower oxygen content is linked to CALs.
Ahmad A. Toubasi, Jarrod J. Eisma, Jiacheng Wang, Habeeb F. Kazimuddin, Bryan Hernandez, Taegan Vinarsky, Caroline Gheen, Zachary Rohm, Carynn Koch, Margareta A. Clarke, Rachael Cheek, John Kramer, James Eaton, Manus J. Donahue, Francesca Bagnato   +14 more
wiley   +1 more source