Results 201 to 210 of about 93,268 (298)

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Transcriptome profiling of tumor-infiltrating lymphocyte-mediated cytotoxicity against patient-derived lung cancer organoids. [PDF]

Commun Biol
Qin Z, Zhang H, Li Y, Yang J, Liu H, Guan Z, Hou Q, Du H, Li X, Lin X, Xu Q, Li Q, Chen J, Liu J, Chen C.   +14 more
europepmc   +1 more source

Few Tumor Infiltrating Lymphocytes [PDF]

, 2020
openaire   +1 more source

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

Interobserver concordance of tumor-infiltrating lymphocyte assessment in triple-negative breast carcinoma; tissue microarray versus whole sections. [PDF]

Cytojournal
Sughayer M, Barakat F, Sweidan E, Maraqa B, Alsughayer A.   +4 more
europepmc   +1 more source

Tumor Infiltrating Lymphocyte Therapy [PDF]

, 2020
openaire   +1 more source

Nano‐Confined Radical Anion as An NIR‐II Photothermal Immunogenic Amplifier for In Situ Cancer Vaccination

Advanced Science, EarlyView.
A nano‐confined radical anion acts as a photothermal immunogenic amplifier. Kinetically stabilized nanoparticles couple high near‐infrared‐II (NIR‐II) photothermal efficacy with glutathione (GSH) depletion to boost reactive oxygen species (ROS) and immunogenic cell death (ICD).
Mengxin Mu, Mengyu Guo, Jun Guan, Xiaofeng He, Mingdi Hu, Fene Gao, Klaus Müllen, Chendong Ji, Chunying Chen, Meizhen Yin   +9 more
wiley   +1 more source

Tumor-Infiltrating Lymphocyte Therapy for Melanoma: Nursing Considerations. [PDF]

Clin J Oncol Nurs
Ferguson KM, Telfort F, Gochett CG.
europepmc   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Multiple autologous tumor-infiltrating lymphocyte (LM103 infusion) therapy combined with immune checkpoint inhibitor induces repeated tumor regression in a patient with aggressive mucosal melanoma: a case report and literature review. [PDF]

Front Oncol
Li F, Xu Y, Wang Y, Mu N, Liu M, Feng W, Xue Y, Wu S, Wang X, Lizee G, Ma C.   +10 more
europepmc   +1 more source