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Cancer Cytopathology, 2022
BackgroundTumor‐infiltrating lymphocytes (TILs) are associated with various clinicopathological features. Using cytologic specimens for assessing TILs remains to be established. This retrospective study aimed to establish a practical method to assess TILs in cytologic samples.MethodsThe authors found 1101 breast fine‐needle aspiration biopsy (FNAB ...
Toru Odate +5 more
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BackgroundTumor‐infiltrating lymphocytes (TILs) are associated with various clinicopathological features. Using cytologic specimens for assessing TILs remains to be established. This retrospective study aimed to establish a practical method to assess TILs in cytologic samples.MethodsThe authors found 1101 breast fine‐needle aspiration biopsy (FNAB ...
Toru Odate +5 more
openaire +2 more sources
Clonal dynamics of tumor-infiltrating lymphocytes
European Journal of Immunology, 2005The presence of tumor-infiltrating lymphocytes (TIL) provides important evidence of anti-tumor immunity in vivo. However, TIL are usually not sufficient for inhibiting tumor growth. We explored the spatial and temporal aspects of clonal accumulation of TIL using RT-PCR/single-strand conformation polymorphism analysis.
Rong, Yu +4 more
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Tumor-Infiltrating Lymphocyte Therapy and Neoantigens
The Cancer Journal, 2017The adoptive cell transfer (ACT) of autologous tumor-infiltrating lymphocytes has been shown to be effective at mediating tumor regression in more than half of patients with metastatic melanoma and in mediating long-term complete regression in approximately one fourth of all patients with this cancer.
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Tumor-infiltrating lymphocytes: A new hope
Cancer CellTumor-infiltrating lymphocytes (TILs) can be massively expanded from resected tumors and used as a cellular treatment for advanced malignancies. TILs require a preparative non-myeloablative chemotherapy followed by an abbreviated course of interleukin-2.
Amod A, Sarnaik +3 more
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Tumor-Infiltrating Lymphocyte Therapy
The Cancer Journal, 2015Autologous adoptive T-cell therapies have made tremendous strides over the last few years with excitement currently being generated by technologies that can reprogram T-cell specificities toward any desired antigen including chimeric antigen receptors and recombinant T-cell receptors.
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Reporting Tumor Infiltrating Lymphocytes
2012The presence of many tumor infiltrating lymphocytes (TILs) in primary cutaneous melanoma is associated with a better prognosis. The degree of lymphocytic interaction with the tumor cells is graded as “brisk”, “non-brisk” or “absent” as defined below:
Kasia Szyfelbein Masterpol +2 more
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Predictors of Tumor-Infiltrating Lymphocyte Efficacy in Melanoma
Immunotherapy, 2015In the past decades, the increasing knowledge in cellular immunology and tumor-host immune interactions, led to the development of immunotherapy approaches. Immunotherapy, based on adoptive cell transfer of ex vivo activated and expanded tumor-infiltrating T lymphocytes (TILs), has shown promising clinical results in patients with metastatic melanoma ...
Dragoslav, Zikich +2 more
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TUMOR INFILTRATING LYMPHOCYTES*
Annals of the New York Academy of Sciences, 1976E, Klein +4 more
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Tumor-infiltrating lymphocytes
Critical Reviews in Oncology/Hematology, 1992Theresa L. Whiteside +2 more
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